Significance of Coronary Artery Disease and Left Ventricular Afterload in Unoperated Asymptomatic Aortic Stenosis

Factors Influencing Cardiac Sympathetic Nervous Function in Patients With Severe Aortic Stenosis: Assessment by 123I-Metaiodobenzylguanidine Myocardial Scintigraphy

“…In agreement with our results, Beach et al [21] showed that patients with AS and CAD had worse short-and longterm prognoses and more postoperative mortality than those with isolated AS. Furthermore, Shibayama et al [22] demonstrated that CAD and high valvulo-arterial impedance, indicating global LV haemodynamic afterload, were independent risk factors of cardiovascular events in unoperated patients with asymptomatic severe AS. However, several reports have shown that lower AVA was associated with poor prognosis in patients with severe AS [23,24].…”