Significance of correlation between levels of carcinoembryonic antigen and carbohydrate antigen 19-9, carcinoembryonic antigen and C-reactive protein, carcinoembryonic antigen and alpha-1 antitrypsin in gastric and colon cancer patients

Bagaria, Bhawna; Bagaria, Ashish; Sharma, Ruchika; Sood, Sadhna; Lalwani, Soniya

doi:10.4103/2278-0513.134477

Cited by 5 publications

(6 citation statements)

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“…CRP is an inflammatory marker. The positive correlations between CRP and CEA or CA biomarkers have been found in other diseases such as gastric and colon cancer, and Parkinson's disease 19,20 . CRP is a crucial factor associated with the severity of COVID‐19 12,13 .…”

Section: Discussionmentioning

confidence: 90%

Elevations of serum cancer biomarkers correlate with severity of COVID‐19

Wei

Yang

et al. 2020

Journal of Medical Virology

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Section: Discussionmentioning

confidence: 90%

Elevations of serum cancer biomarkers correlate with severity of COVID‐19

Wei

Yang

et al. 2020

Journal of Medical Virology

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“…Positive correlations between CRP and CEA or CA biomarkers have been found in other diseases such as gastric and colon cancer and Parkinson's disease. 8,9 Another author Li et al 10 in their research bring up an important consideration for COVID-19 patients who had significantly increased serum amyloid A protein (SAA) and CRP levels, while lymphocyte count decreased, and procalcitonin, WBC, and PLT were in the normal range. SAA is a nonspecific acute phase protein mainly produced by cytokines interleukin-1β (IL-1β), IL-6, and tumor necrosis factor-α (TNF-α) in liver cells.…”

Section: Discussionmentioning

confidence: 99%

“…Our study unveils that a positive correlation between CRP and a series of cancer biomarkers can inform us about an acute pathophysiological injury in COVID‐19. Positive correlations between CRP and CEA or CA biomarkers have been found in other diseases such as gastric and colon cancer and Parkinson's disease 8,9 …”

Section: Discussionmentioning

confidence: 99%

“…Positive correlations between CRP and CEA or CA biomarkers have been found in other diseases such as gastric and colon cancer and Parkinson's disease. 8,9 Another author Li et al 10 Therefore, early diagnosis and appropriate treatment are important in reducing the morbidity and mortality of COVID-19-infected patients. 4,14 Inflammatory factors, such as SAA, CRP, L, PCT, WBC, and PLT are frequently used to predict, diagnose and evaluate many inflammatory diseases.…”

Section: Discussionmentioning

confidence: 99%

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Effect of the coronavirus pandemic on tumor markers

Purut

Giray

Gürbüz

2021

Journal of Medical Virology

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The new type of coronavirus could cause severe acute respiratory syndrome and injuries in other systems as well. Multiple organ damage can occur rapidly in patients infected with coronavirus disease 2019 (COVID‐19). Previous studies have shown that many laboratory biomarkers were not within the normal ranges in COVID‐19 patients. We aimed to summarize laboratory parameters and the tumor markers in COVID‐19 patients. This is a retrospective cohort study conducted on 53 women between the ages of 19–85 years infected with COVID‐19 at a training and research hospital between May 2020 and August 2020. Of the 53 women, 16 (30.2%) had leukopenia. The mean C‐reactive protein level was 18.42 ± 59.33 mg/L. The mean procalcitonin level was 0.1 ± 0.21 µg/L. The liver function tests were within normal limits. The mean creatinine level was 0.58 ± 0.37 mg/dl. Elevated levels of α‐fetoprotein (AFP) in 1 patient, elevated levels of carcinoembryonic antigen (CEA) in 2 patients, elevated levels of cancer antigen 125 (CA125) in 4 patients, elevated levels of CA19‐9 in 2 patients, and elevated levels of CA15‐3 in 2 patients were detected. One of 4 patients who were taken to the intensive care unit had elevated levels of AFP. In addition, 2 of 4 patients who were taken to the intensive care unit had elevated levels of CA125 and CA15‐3. Except for AFP, levels of all tumor markers of the patient who died were high. We found that COVID‐19 had no effect on tumor markers (CA125, CA19‐9, CA15‐3, AFP, and CEA).

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“…In this analysis, the authors excluded any subjects with tumor diagnoses; therefore, the increase of these cancer markers was not correlated with pre-existing situations of tumorigenesis. Moreover, numerous previous studies have established that cancer biomarkers are also elevated in various inflammatory conditions in the lungs [ 55 , 56 , 57 , 58 , 59 , 60 ] ( Table 2 ).…”

Section: Diagnostic Challenges In the Recognition Of Sars-cov-2 Inmentioning

confidence: 99%

Cancer and SARS-CoV-2 Infection: Diagnostic and Therapeutic Challenges

Allegra

Pioggia

Tonacci

et al. 2020

Cancers

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In late December 2019, a new infectious viral disease appeared. A new betacoronavirus, severe acute respiratory syndrome coronavirus 2 (SARS-Cov-2), has been recognized as the pathogen responsible for this infection. Patients affected by tumors are more vulnerable to infection owing to poor health status, concomitant chronic diseases, and immunosuppressive conditions provoked by both the cancer and antitumor therapies. In this review, we have analyzed some lesser known aspects of the relationship between neoplasms and SARS-CoV-2 infection, starting from the different expression of the ACE2 receptor of the virus in the various neoplastic pathologies, and the roles that different cytokine patterns could have in vulnerability to infection and the appearance of complications. This review also reports the rationale for a possible use of drugs commonly employed in neoplastic therapy, such as bevacizumab, ibrutinib, selinexor, thalidomide, carfilzomib, and PD-1 inhibitors, for the treatment of SARS-CoV-2 infection. Finally, we have highlighted some diagnostic challenges in the recognition of SARS-CoV-2 infection in cancer-infected patients. The combination of these two health problems—tumors and a pandemic virus—could become a catastrophe if not correctly handled. Careful and judicious management of cancer patients with SARS-Cov-2 could support a better outcome for these patients during the current pandemic.

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Significance of correlation between levels of carcinoembryonic antigen and carbohydrate antigen 19-9, carcinoembryonic antigen and C-reactive protein, carcinoembryonic antigen and alpha-1 antitrypsin in gastric and colon cancer patients

Cited by 5 publications

References 1 publication

Elevations of serum cancer biomarkers correlate with severity of COVID‐19

Elevations of serum cancer biomarkers correlate with severity of COVID‐19

Effect of the coronavirus pandemic on tumor markers

Cancer and SARS-CoV-2 Infection: Diagnostic and Therapeutic Challenges

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