Significance of cuproptosis- related genes in the diagnosis and classification of psoriasis

Lin, Qingyuan; Zhu, Jinchao; Chen, Jun; Jia, Shouqiang; Nie, Shengdong

doi:10.3389/fmolb.2023.1115091

Cited by 4 publications

(3 citation statements)

References 38 publications

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“…Cuproptosis represents a novel type of cellular death associated with mitochondrial metabolism and facilitated through protein lipoylation [131]. The occurrence of cell death induced by copper ionophores depends predominantly upon the intracellular accumulation of copper.…”

Section: Ferroptosis Pyroptosis and Cuproptosismentioning

confidence: 99%

“…Cuproptosis and elevated copper levels in serum may be involved in the pathogenesis of psoriasis by mechanisms largely unknown [131]. The accumulation of intracellular copper leads to cell death, and the cuproptosis-related genes MTF1, ATP7B, and SLC31A1 are increasingly expressed in patients with psoriasis compared to patients without psoriasis [131].…”

Section: Ferroptisis Pyroptosis and Cuproptosis In Psoriasismentioning

confidence: 99%

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Multi-Omics Approach to Improved Diagnosis and Treatment of Atopic Dermatitis and Psoriasis

Rusiñol,

Puig

2024

IJMS

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Psoriasis and atopic dermatitis fall within the category of cutaneous immune-mediated inflammatory diseases (IMIDs). The prevalence of IMIDs is increasing in industrialized societies, influenced by both environmental changes and a genetic predisposition. However, the exact immune factors driving these chronic, progressive diseases are not fully understood. By using multi-omics techniques in cutaneous IMIDs, it is expected to advance the understanding of skin biology, uncover the underlying mechanisms of skin conditions, and potentially devise precise and personalized approaches to diagnosis and treatment. We provide a narrative review of the current knowledge in genomics, epigenomics, and proteomics of atopic dermatitis and psoriasis. A literature search was performed for articles published until 30 November 2023. Although there is still much to uncover, recent evidence has already provided valuable insights, such as proteomic profiles that permit differentiating psoriasis from mycosis fungoides and β-defensin 2 correlation to PASI and its drop due to secukinumab first injection, among others.

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Section: Ferroptosis Pyroptosis and Cuproptosismentioning

confidence: 99%

Section: Ferroptisis Pyroptosis and Cuproptosis In Psoriasismentioning

confidence: 99%

Multi-Omics Approach to Improved Diagnosis and Treatment of Atopic Dermatitis and Psoriasis

Rusiñol,

Puig

2024

IJMS

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“…Psoriatic lesions can appear on the scalp, palms, soles, genitals, and nails. Nail involvement is common in psoriatic arthritis patients [ 5 ].…”

Section: Introductionmentioning

confidence: 99%

Excimer Laser System: The Revolutionary Way to Treat Psoriasis

Alyoussef

2023

Cureus

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Psoriasis is a chronic, autoinflammatory skin disease that affects approximately 100 million people worldwide. It is a systemic disease characterized by scaly, red patches on the skin and can also affect the joints. Psoriasis can significantly affect a person's physical and mental health. The prevalence rate of psoriasis may vary depending on the specific population studied and the diagnostic criteria used. Phototherapy is a safe and effective treatment for psoriasis that involves exposing the affected skin to specific wavelengths of light. It can be used alone or with other treatments for severe psoriasis. However, clinicians must choose the right light source for each type of psoriasis and monitor the patient closely during treatment to avoid adverse events. The 308 nm excimer laser is a widely used device in dermatology for treating several skin conditions, including psoriasis. Although the excimer laser can treat various dermatologic diseases, this study will focus only on its effectiveness in treating psoriasis. This study will review the use of an excimer laser, its protocol, and its side effects.

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Identification of cuproptosis-related genes in septic shock based on bioinformatic analysis

Zhao,

Zhang,

Wang

et al. 2024

PLoS ONE

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Background Septic shock is a life-threatening condition characterized by a failure of organ systems and a high mortality rate. Cuproptosis is a new form of cell death that is triggered by copper overload. However, the relationship between cuproptosis-related genes and septic shock remains unclear. Methods The GSE26440 dataset from the GEO database was used to screen differentially expressed genes (DEGs) between control and septic shock samples. Additionally, hub genes related to the progression of septic shock and cuproptosis were screened by Venn analysis. RT-qPCR was utilized to validate the expression of hub genes in peripheral blood lymphocytes from septic shock patients and healthy controls. Next, functional analysis and immune cells infiltration were performed. Results SLC31A1 and MTF1 levels were obviously elevated and LIAS and LIPT1 levels were downregulated in septic shock samples, compared to normal controls. The diagnostic values of the four genes were confirmed with receiver operating characteristic (ROC) curves. Additionally, SLC31A1 and MTF1 showed a positive correlation with natural killer cells and LIAS and LIPT1 exhibited a positive correlation with CD8+ T cells. Furthermore, compared to low-level groups, MAPK signaling was activated in the high-SLC31A1 level group, VEGF signaling was activated in the high-MTF1 level group and lipoic acid metabolism was activated in high-LIAS and high-LIPT1 level groups. Conclusion This study demonstrates that SLC31A1, MTF1, LIAS, and LIPT1 are dysregulated in septic shock samples, and these genes exhibit potential diagnostic efficacy in septic shock, suggesting that these genes may be potential biomarkers for the diagnosis of septic shock.

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Significance of cuproptosis- related genes in the diagnosis and classification of psoriasis

Cited by 4 publications

References 38 publications

Multi-Omics Approach to Improved Diagnosis and Treatment of Atopic Dermatitis and Psoriasis

Multi-Omics Approach to Improved Diagnosis and Treatment of Atopic Dermatitis and Psoriasis

Excimer Laser System: The Revolutionary Way to Treat Psoriasis

Identification of cuproptosis-related genes in septic shock based on bioinformatic analysis

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