Significance of cytogenetic findings for the clinical outcome in patients with T-cell lymphoma of angioimmunoblastic lymphadenopathy type.

Schlegelberger, Brigitte; Zwingers, T.; Hohenadel, Karin; Henne‐Bruns, Doris; Schmitz, Norbert; Haferlach, T.; Tirier, C.; Bartels, H.; Sonnen, R; Kuse, R.

doi:10.1200/jco.1996.14.2.593

Cited by 58 publications

(31 citation statements)

References 19 publications

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“…Several recurrent breakpoints were noted in all three PTCL subgroups, including regions previously associated with B-and T-cell lymphoma, such as 1p36, 6q21, 7p15, 11q13, 14q11.2, 14q32, 17p13, 19q13, 22q11.2 and 22q13 (Berger et al, 1988;Inwards et al, 1990;Kaneko et al, 1988;Lepretre et al, 2000;Michaux et al, 1996;Schlegelberger et al, 1994aSchlegelberger et al, ,b, 1996. Recurrent breakpoints were also observed at 16q22 and 16q24, regions not currently associated with lymphoma.…”

Section: Discussionmentioning

confidence: 95%

“…Although the karyotypes are complex among uncategorized PTCL, frequent rearrangements involving chromosomes 1, 6q, 14q11, 7p, 7q, 9p, and 10p have been reported (Berger et al, 1988;Inwards et al, 1990;Kaneko et al, 1988;Lepretre et al, 2000;Schlegelberger et al, 1994aSchlegelberger et al, ,b, 1996. Recurrent abnormalities noted among specific subtypes of PTCL include the t(2;5)(p23;q35) and other translocation variants in ALKpositive ALCL (Wellmann et al, 1995;Rosenwald et al, 1999), and trisomies of 3 and 5 in AITL (Schlegelberger et al, 1994b(Schlegelberger et al, , 1996. Comparative genomic hybridization (CGH) studies analyzing two out of the three main subtypes of PTCL have also been recently reported (Zettl et al, 2004;Thorns et al, 2007).…”

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confidence: 99%

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Cytogenetic abnormalities and clinical correlations in peripheral T‐cell lymphoma

et al. 2008

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SummaryCytogenetic correlations among most types of peripheral T-cell lymphoma (PTCL) have not been very informative to date. This study aimed to identify recurrent chromosomal abnormalities in angioimmunoblastic T-cell lymphoma (AITL), ALK-negative anaplastic large cell lymphoma (ALK-ALCL) and peripheral T-cell lymphoma, unspecified (PTCL-US), and to evaluate their prognostic value. We reviewed the cytogenetic findings of 90 previously-diagnosed cases of PTCL and correlated the cytogenetic findings with the specific histological subtype. The most common abnormalities for AITL were 5q (55%), 21 (41%) and 3q (36%) gains, concurrent trisomies of 5 and 21 (41%), and loss of 6q (23%). In ALK(-) ALCL, gains of 1q (50%) and 3p (30%), and losses of 16pter (50%), 6q13q21 (30%), 15 (30%), 16qter (30%) and 17p13 (30%) were frequent findings. In PTCL-US, frequent gains involved 7q22q31 (33%), 1q (24%), 3p (20%), 5p (20%), and 8q24qter (22%), and losses of 6q22q24 (26%) and 10p13pter (26%). We did not observe any association between specific chromosomal abnormalities and overall survival (OS). However, cases with complex karyotypes, most frequently observed in ALK(-) ALCL and PTCL-US, had a significantly shorter OS. Although, genetic differences were noted in these subtypes, further studies are needed to determine the key pathogenetic events in PTCL.

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Section: Discussionmentioning

confidence: 95%

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confidence: 99%

Cytogenetic abnormalities and clinical correlations in peripheral T‐cell lymphoma

et al. 2008

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“…Moreover, except for some cytogenetic results, such as the presence of an additional X chromosome, structural aberrations of the short arm of chromosome 1 and complex karyotypes, associated with a poor prognosis, 13 little is known about the prognostic impact of chromosome abnormalities in T cell NHL. This lack of information is also evident when it comes to CGH studies, while there are different reports about the CGH profile in B-NHL, there are no studies of T-NHL series that have looked for gains or losses of DNA sequences in the genome of these lymphomas.…”

Section: Discussionmentioning

confidence: 99%

Chromosomal changes pattern and gene amplification in T cell non-Hodgkin's lymphomas

Renedo¹,

Martı́nez-Delgado

Arranz

et al. 2001

Leukemia

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T cell non-Hodgkin's lymphomas are a heterogeneous group of lymphomas with poor prognosis, and whose genetic alterations are not well understood. Comparative genomic hybridization (CGH) is a technique that allows the identification of DNA imbalances without cytogenetic studies. We have studied 37 samples from 29 T cell non-Hodgkin's lymphomas (25 peripheral and four lymphoblastic lymphomas) by CGH in order to detect DNA sequence copy number changes of putative importance in the biology and prognosis of these neoplasms. We detected abnormal CGH profiles in 16/27 (59%) of samples at diagnosis, a ratio that increased to 66% (23/37) when we included the relapsed samples. The most common recurrent changes were gains related to the X chromosome, either the whole chromosome or partially the Xq26-27 bands (19%).

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“…Little is known regarding predictors of spontaneous remission; however, one study showed factors that might predict this event (11). It showed that having an extra third chromosome was associated with a higher chance of spontaneous remission (P = 0.02) and an extra X chromosome showed an insignifi cant trend for less chance of remission (P = 0.09).…”

Section: Discussionmentioning

confidence: 99%

“…Th e spontaneous remission of AITL without therapy is quite unusual and, although not unknown to the medical literature (9)(10)(11), is still a very rare occurrence. Little is known regarding predictors of spontaneous remission; however, one study showed factors that might predict this event (11).…”

Section: Discussionmentioning

confidence: 99%

Spontaneous Complete Remission of Angioimmunoblastic T-Cell Lymphoma

Humeniuk¹,

Liang²,

Howard³

et al. 2014

Baylor University Medical Center Proceedings

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Angioimmunoblastic T-cell lymphoma (AITL) is a rare hematologic neoplasm that typically presents with B symptoms, anemia, and lymphadenopathy. Its overall prognosis is poor, with a 5-year survival rate of 30%. We present a case of AITL that went into spontaneous remission, an uncommon occurrence.A ngioimmunoblastic T-cell lymphoma (AITL) is a rare hematologic neoplasm that classically presents with lymphadenopathy, hepatosplenomegaly, anemia, and B-type symptoms. Although the disease has a poor prognosis, we present a patient with a rare spontaneous remission. CASE REPORTA 63-year-old man with a congenitally bicuspid aortic valve and benign prostate hypertrophy presented to the emergency department complaining of cyclical fevers and 20-pound unintentional weight loss over the previous 3 weeks and was admitted to the hospital for workup of fever of unknown origin. Th ese fevers reached 40°C and occurred regularly at 6-to 12-hour intervals, lasting 90 minutes each time before resolving completely. Review of systems was also positive for urinary retention, frequency, and perineal burning sensation.Th e patient had spent large amounts of time in many countries in Africa, Eastern Asia, and South and Central America. While in Egypt 2 years earlier, he was bitten by a spider and developed signifi cant left cervical lymphadenopathy. A cervical lymph node biopsy in Poland was reportedly benign. Th e procedure was complicated by left spinal accessory nerve damage, and 6 months prior to onset of his presenting symptoms he underwent surgical repair of the nerve at our institution. At that time another cervical lymph node was biopsied, which was benign, and his lactate dehydrogenase (LDH) level was 183 U/L (normal, 122-222 U/L).Physical examination revealed bilateral tender cervical and submandibular lymphadenopathy, but no axillary or inguinal lymphadenopathy. A harsh precordial systolic murmur consistent with aortic stenosis was audible. No hepatosplenomegaly was found. Except for the presence of IgG antibodies to EpsteinBarr virus (EBV) viral capsid antigen and Epstein-Barr nuclear antigen, serologic testing for multiple infections was negative ( Table 1). Results of a peripheral smear, blood cultures, and urinalysis were all negative, and the chest x-ray showed no infi ltrates. Computed tomography scan of the abdomen revealed periaortic and periportal lymphadenopathy and splenomegaly. Flow cytometry revealed no increase in aberrant CD3/CD16-positive T cells or increase in natural killer cells. T-cell receptor gene rearrangement showed clonal T cells. Due to the clinical presentation and elevated infl ammatory markers (Table 2), he was diagnosed with acute prostatitis. Ciprofl oxacin led to prompt resolution of fevers. He was discharged home on day 5 with antibiotics but returned within a week due to fever recurrence. At this time, magnetic resonance imaging of the prostate

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Significance of cytogenetic findings for the clinical outcome in patients with T-cell lymphoma of angioimmunoblastic lymphadenopathy type.

Abstract: This is the first study that seems to indicate that cytogenetic findings have prognostic significance in AILD-type T-cell lymphoma. These results must be proven in prospective studies of homogeneously treated patients.

Cited by 58 publications

References 19 publications

Cytogenetic abnormalities and clinical correlations in peripheral T‐cell lymphoma

Cytogenetic abnormalities and clinical correlations in peripheral T‐cell lymphoma

Chromosomal changes pattern and gene amplification in T cell non-Hodgkin's lymphomas

Spontaneous Complete Remission of Angioimmunoblastic T-Cell Lymphoma

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