2020
DOI: 10.1080/01677063.2019.1710144
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Significance of DopEcR, a G-protein coupled dopamine/ecdysteroid receptor, in physiological and behavioral response to stressors

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Cited by 28 publications
(20 citation statements)
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“…4a,d). The DopEcR mutant flies are less sensitive to ethanol sedation 66,67 , and show defects in dealing with various stressors such as starvation, heat and sexual rejection [68][69][70] . Therefore, DopEcR might mediate aversive effects of drugs, which include ethanol sedation, thereby function as a 'brake' for the further drug intake.…”
Section: Discussionmentioning
confidence: 99%
“…4a,d). The DopEcR mutant flies are less sensitive to ethanol sedation 66,67 , and show defects in dealing with various stressors such as starvation, heat and sexual rejection [68][69][70] . Therefore, DopEcR might mediate aversive effects of drugs, which include ethanol sedation, thereby function as a 'brake' for the further drug intake.…”
Section: Discussionmentioning
confidence: 99%
“…Since there are no adrenal glands in insects, the corresponding secondary hormones are not known in insects. Perhaps octopamine (OA) and dopamine (DA), as well as Ecd and JH, are part of the stress signaling downstream of DILPs and CRZ (Gruntenko et al 2016 ; Gruntenko et al 2005 ; Gruntenko et al 2010 ; Lubawy et al 2020 ; Petruccelli et al 2020 ; Roeder 2020 ; Zhao et al 2010 ). Thus, the cellular sources of insect stress factors are in adults spread out into CA (JH), sets of neurons (OA, DA) and gonads (Ecd).…”
Section: Do Insect Neurosecretory Cell Systems Share Functions With Tmentioning
confidence: 99%
“…In the gypsy moth Lymantria dispar , for example, larval crowding results in a decreased concentration of the hormone dopamine in the hemolymph ( Pavlushin et al 2019 ). In Drosophila , crowding induces heat shock proteins (reviewed by King and MacRae 2015 ) and affects the dopamine/ecdysteroid receptor that modulates intracellular signaling pathways in response to various stressors (reviewed by Petruccelli et al 2020 ). In locusts, higher population density causes solitary-to-gregarious phase transformation, and many internal regulatory chemical agents and signal molecules are known to play a role (reviewed by Ayali 2019 ).…”
Section: Discussionmentioning
confidence: 99%