Significance of elevated gingival crevicular fluid tumor necrosis factor-α and interleukin-8 levels in chronic hemodialysis patients with periodontal disease

Dağ, Ahmet; Elif
, FIRAT,; Kadiroğlu, A. K.; Kale, Ebru; Yılmaz, Mehmet Emin

doi:10.1111/j.1600-0765.2009.01252.x

Cited by 18 publications

(17 citation statements)

References 26 publications

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“…However, to our knowledge, a significant correlation between periodontal disease and white blood cell counts was found in only one study [36]. In addition, the number of white blood cells in the gingival crevicular fluid of HD patients with periodontal disease (mean/SD: 6.05/1.81 k/μL) was significantly lower ( p < 0.001) than that in a control group (7.02/1.30 k/μL) [53]. Based on these findings, the impact of inflammation on circulating white blood cell counts in HD patients with periodontal disease can be considered minimal.…”

Section: Hemodialysismentioning

confidence: 99%

Periodontal Disease in Patients Receiving Dialysis

Miyata

Obata

Mochizuki

et al. 2019

IJMS

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Chronic kidney disease (CKD) is characterized by kidney damage with proteinuria, hematuria, and progressive loss of kidney function. The final stage of CKD is known as end-stage renal disease, which usually indicates that approximately 90% of normal renal function is lost, and necessitates renal replacement therapy for survival. The most widespread renal replacement therapy is dialysis, which includes peritoneal dialysis (PD) and hemodialysis (HD). However, despite the development of novel medical instruments and agents, both dialysis procedures have complications and disadvantages, such as cardiovascular disease due to excessive blood fluid and infections caused by impaired immunity. Periodontal disease is chronic inflammation induced by various pathogens and its frequency and severity in patients undergoing dialysis are higher compared to those in healthy individuals. Therefore, several investigators have paid special attention to the impact of periodontal disease on inflammation-, nutrient-, and bone metabolism-related markers; the immune system; and complications in patients undergoing dialysis. Furthermore, the influence of diabetes on the prevalence and severity of manifestations of periodontal disease, and the properties of saliva in HD patients with periodontitis have been reported. Conversely, there are few reviews discussing periodontal disease in patients with dialysis. In this review, we discuss the available studies and review the pathological roles and clinical significance of periodontal disease in patients receiving PD or HD. In addition, this review underlines the importance of oral health and adequate periodontal treatment to maintain quality of life and prolong survival in these patients.

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Section: Hemodialysismentioning

confidence: 99%

Periodontal Disease in Patients Receiving Dialysis

Miyata

Obata

Mochizuki

et al. 2019

IJMS

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“…The cells were cultured at 37°C in 5% CO 2 / 95% air in DMEM containing 10% FCS. They were grown to confluence in 100-mm tissue culture dishes, and the medium was then changed to DMEM containing 1% FCS for 12 h, followed by incubation in this medium with or without IL-1β (1 ng/mL), IL-6 (1 ng/mL), and TNF-α (10 ng/mL) for 24 h as described previously (13)(14)(15)(16)(17)(18)(19). Total RNA was isolated from quadruplicate cultures and analyzed for the expression of AMTN and glyceraldehyde-3-phosphate dehydrogenase (GAPDH) mRNA by real-time PCR as described below.…”

Section: Cell Culturementioning

confidence: 99%

Proinflammatory cytokines induce amelotin transcription in human gingival fibroblasts

et al. 2014

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“…It offers advantages over serum because its collection is noninvasive and requires no special training on the side of the clinician. Furthermore, saliva analysis showed of biochemical and immunological variation comparable to those in blood evaluated as routine practice [3,4].…”

Section: Discussionmentioning

confidence: 69%

Diagnostic and Prognostic Particularities of the Implications of the Presence of Tumor Necrosis Factor Alpha in Patients with Periodontal Disease

Ieremie

Lazăr

Ciurba

2014

Acta Medica Marisiensis

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Periodontal disease can have significant effects by increasing the circulating levels of TNF-α, therefore its prevention and treatment is important in maintaining the overall health of the body. Objective: The aim of our research was to assess the differences in the salivary concentration of TNF-α between patients with periodontal disease and those free of the disease and to studz whether it can represent an indicator of the evolution of periodontal disease. We also aimed to assess the practical applicability of the method for the determination of this cytokine in the saliva. Materials and methods: Our study included two groups of subjects, the first group consisting in patients diagnosed with periodontal disease, while the control group included subjects free of periodontal disease. TNF-α concentration was determined with the ELISA test for human TNF-α and the results were expressed in pg/ mL. The data were statistically processed with GraphPad software and the statistical nonparametric Mann-Whitney test was applied. Results: We observe nearly double values of the TNF-α salivary level in the group of patients suffering from periodontal disease compared to the subjects free of periodontal disease, which allows us to notice that saliva analysis is a useful and safely enough method for the diagnosis and follow-up in the development of periodontal disease. Conclusion: The salivary level of TNF-α in patients with periodontal disease is not only an indicator of periodontal disease progression, but also a reflection of the pathogen potential that periodontal disease may have on the overall health of the body.

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Significance of elevated gingival crevicular fluid tumor necrosis factor-α and interleukin-8 levels in chronic hemodialysis patients with periodontal disease

Cited by 18 publications

References 26 publications

Periodontal Disease in Patients Receiving Dialysis

Periodontal Disease in Patients Receiving Dialysis

Proinflammatory cytokines induce amelotin transcription in human gingival fibroblasts

Diagnostic and Prognostic Particularities of the Implications of the Presence of Tumor Necrosis Factor Alpha in Patients with Periodontal Disease

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