Significance of eosinophil accumulation in the thrombus and decrease in peripheral blood in patients with acute coronary syndrome

Jiang, Ping; Wang, Dezhao; Ren, Yali; Cai, Jian‐Ping; Chen, Buxing

doi:10.1097/mca.0000000000000186

Cited by 45 publications

(48 citation statements)

References 25 publications

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“…Two retrospective studies and three cross sectional studies showed that there was a significant correlation between eosinophil count and the risk of CHD, but other studies found no association. 30,[38][39][40][43][44][45][46] Our retrospective study and meta-analysis found that eosinophil count had the significant association with the risk of CHD.…”

Section: Discussionmentioning

confidence: 99%

“…Of 16 studies, five studies were compatible for metaanalysis with a total of 889 CHD patients and 4306 controls (Table 3). 22,[29][30][31][32][33][34][35][36][37][38][39][40][41][42][43] Mean (±SD) We found that elevated leukocyte had a significant association with the incidence of CHD (OR 95%CI=3.57 [1.84-6.93], p<0.001) ( Table 3, Figure 2 A).…”

Section: Meta-analysismentioning

confidence: 99%

“…For the association between eosinophil and CHD, eight studies were identified; four retrospective studies, three cross sectional studies and one cohort study. 30,[38][39][40][43][44][45][46] Of these, five studies and our results with a total 513 CHD patients and 3998 controls were included in our meta-analysis. 30,[38][39][40]43 The results found that elevated eosinophil count had the significant association with the risk of CHD (OR 95%CI = 5.34 [1.17-24.77], p=0.031) ( Table 3, Figure 2 B).…”

Section: Meta-analysismentioning

confidence: 99%

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The Association Between Complete Blood Count and the Risk of Coronary Heart Disease

Fajar¹,

Mahendra²,

Tamara³

et al. 2019

Turkiye Klinikleri J Med Sci

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oronary heart disease (CHD) remains a serious health problem. The reports revealed that CHD has caused 11.2% global deaths. Although crude mortality rate for CHD remains stable, this number increases rapidly with age. 1-3 Atherosclerosis of coronary arteries, the main cause of CHD, is a complex inflammatory disorder that causes the changes in the cells of the arterial wall and the blood components. 4,5 Several inflammatory biomarkers such as troponin, C reactive protein (CRP), and Btype natriuretic peptide (BNP) or pro-BNP are used to stratify the risk of The Association Between Complete Blood Count and the Risk of Coronary Heart Disease A AB BS S T TR RA AC CT T O Ob bj je ec ct ti iv ve e: : To determine the correlation between complete blood count and the risk of coronary heart disease (CHD). M Ma at te er ri ia al l a an nd d M Me et th ho od ds s: : All CHD patients treated in Aisyiyah Hospital during January 2011 to December 2017 were enrolled for the study. Information related to demographic, clinical, and complete blood count were extracted from medical record. Multiple logistic regression test was employed to evaluate the correlation between complete blood count and CHD incidence. In addition, a meta-analysis was also conducted to summarize findings from other regions. R Re es su ul lt ts s: : A total of 516 CHD patients and 102 controls were included in our study. We found that elevated hemoglobin (OR 95%CI=4.92 [2.02-12.01], p=0.002), leukocyte (OR 95%CI=5.35 [3.17-9.03], p=0.001), hematocrit (OR 95%CI=2.31 [1.40-3.83], p=0.010), eosinophil (OR 95%CI= 2.78 [1.68-4.26], p=0.001), and monocyte (OR 95%CI=1.31 [0.80-2.16], p=0.023) were associated with the incidence of CHD. Furthermore, our meta-analysis revealed that elevated levels of leukocyte, eosinophil, and monocyte increased the risk of CHD approximately 3.57, 5.34, and 2.77 times, respectively. C Co on nc cl lu us si io on n: : There is strong evidence that elevated levels of leukocyte, eosinophil, and monocyte are the risk factor for CHD. K Ke ey yw wo or rd ds s: : Complete blood count; coronary heart disease; risk factor Ö ÖZ ZE ET T A Am ma aç ç: : Tam kan ayımı ile koroner kalp hastalığı (KKH) arasında korelasyon olup olmadığını araştırmak amaçlandı. G Ge er re eç ç v ve e Y Yö ön nt te em ml le er r: : Aisyiyah Hastanesi'nde Ocak 2011-Aralık 2017 arasında tedavi gören tüm KKH hastaları çalışma kapsamına alındı. Hastalarla ilgili demografik bilgiler, klinik veriler ve tam kan sayımları tıbbi kayıtlardan alındı. Aradaki bağlantıyı incelemek için multipl lojistik regresyon analizi yapıldı. KKH insidansı analizine ilaveten diğer yayınlardan elde edilen özet verilerin meta-analizi yapıldı. B Bu ul lg gu ul la ar r: : Toplam 516 KKH hastası ve 102 kontrol kişisi çalışmaya alındı. KKH insidansı ile ilişkili olarak hemoglobin (OR %95 GA=4,

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Section: Discussionmentioning

confidence: 99%

Section: Meta-analysismentioning

confidence: 99%

Section: Meta-analysismentioning

confidence: 99%

See 1 more Smart Citation

The Association Between Complete Blood Count and the Risk of Coronary Heart Disease

Fajar¹,

Mahendra²,

Tamara³

et al. 2019

Turkiye Klinikleri J Med Sci

View full text Add to dashboard Cite

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“…To our knowledge, this is the first study reported that eosinophil and basophil are prognostic factors for AMI. Jiang et al (20) found that eosinophil percentage was inversely correlated with cardiac troponin I level in AMI. Although that study suggested that eosinophil percentage was a potential prognostic factor, the prognostic value of eosinophil percentage was not further investigated.…”

Section: Discussionmentioning

confidence: 99%

Lower mean corpuscular hemoglobin concentration is associated with poorer outcomes in intensive care unit admitted patients with acute myocardial infarction

Huang¹,

Hu²

2016

Annals of Translational Medicine

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Background: Accumulated studies have shown that hematological parameters [e.g., red blood cell distribution width (RDW), hemoglobin, platelet count] and serum potassium level can impact the prognosis of patients with acute myocardial infarction (AMI). However, no previous study has evaluated the prognostic values of these laboratory tests simultaneously.Methods: This study is based on an intensive care unit (ICU) database named Multiparameter Intelligent Monitoring in Intensive Care II (MIMIC II). Adult patients with AMI were included, and their hematological parameters and serum ion levels on admission were extracted. The relationships between these laboratory tests and hospital mortality were evaluated using a logistic regression model and receiver operating characteristic (ROC) curve analysis. The effects of these laboratory tests on 1-year mortality were evaluated using a Cox hazard regression model and Kaplan-Meier curve analysis.Results: In univariable analysis, increased white blood cell (WBC), neutrophil percentage, mean corpuscular volume (MCV), RDW, potassium and decreased red blood cell (RBC), hemoglobin, mean corpuscular hemoglobin concentration (MCHC), hematocrit and percentage of lymphocyte, monocyte, basophil and eosinophil were significantly associated with hospital mortality. In multivariable analyses, basophil percentage, potassium, WBC and MCHC were independently associated with hospital morality, while WBC, RDW, MCHC, potassium and percentages of neutrophil and lymphocyte were associated with 1-year mortality.Conclusions: Hematological parameters and serum potassium can provide prognostic information in AMI patients. MCHC is an independent prognostic factor for both short and long term outcomes of AMI.

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“…Angina pectoris tends to be accompanied by thrombosis [18]. Therefore, drinking an adequate amount of water may help reduce blood coagulation and result in a lower OR for angina pectoris.…”

Section: Discussionmentioning

confidence: 99%

Relationship Between Water Intake and Metabolic/Heart Diseases: Based on Korean National Health and Nutrition Examination Survey

Jang

Cheon

Jang

et al. 2016

Osong Public Health and Research Perspectives

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ObjectivesThe aim of this study was to identify the correlation between adequate water intake and the prevalence of metabolic/heart diseases.MethodsWe analyzed the data from the 2012 Korea National Health and Nutrition Examination Survey. All participants were divided into Group Above Adequate Intake (n = 736) and Group Below Adequate Intake (n = 4,819) according to water intake. The thresholds were 1.8 L for men and 1.4 L for women based on the World Health Organization report findings. Logistic regression analyses were performed to verify the correlation between water intake and prevalence of hypertension, diabetes mellitus, dyslipidemia, myocardial infarction, and angina pectoris.ResultsThere were significant differences between the two groups in terms of the following variables: age, smoking, alcohol, stress, dietary supplements, body weight, physical activity, total calorie intake, water intakes from food, and sodium intake. Participants in Group Above Adequate Intake showed a higher prevalence of hypertension [odds ratio (OR) = 1.22; 95% confidence interval (CI), 0.58–2.55], diabetes mellitus (OR = 1.38; 95% CI, 0.51–3.73), angina pectoris (OR = 0.94; 95% CI, 0.47–1.86), and myocardial infarction (OR = 5.36; 95% CI, 0.67–43.20) than those in Group Below Adequate Intake, whereas the latter showed a slightly higher prevalence of dyslipidemia (OR = 2.25; 95% CI, 0.88–57.84) than the former.ConclusionThere was no statistically significant association between water intake and any of the metabolic/heart diseases. However, further studies on water intake are needed to confirm our findings.

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Significance of eosinophil accumulation in the thrombus and decrease in peripheral blood in patients with acute coronary syndrome

Cited by 45 publications

References 25 publications

The Association Between Complete Blood Count and the Risk of Coronary Heart Disease

The Association Between Complete Blood Count and the Risk of Coronary Heart Disease

Lower mean corpuscular hemoglobin concentration is associated with poorer outcomes in intensive care unit admitted patients with acute myocardial infarction

Relationship Between Water Intake and Metabolic/Heart Diseases: Based on Korean National Health and Nutrition Examination Survey

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