Significance of Exercise QT Dispersion in Patients With Coronary Artery Disease Who do not Have Exercise-Induced Ischemic ST-Segment Changes

Yoshimura, M; Matsumoto, Koji; Watanabe, Masashi; Yamashita, Naoko; Sanuki, Eiko; Sumida, Yukinobu

doi:10.1253/jcj.63.517

Cited by 3 publications

(3 citation statements)

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“…15,[19][20][21] The QTD at rest measured in hypertensives without LVH in the present study was consistent with that of healthy subjects described in previous reports. Therefore, the QTD at rest does not increase in hypertensives without LVH.…”

Section: Discussionsupporting

confidence: 92%

“…QTD in healthy subjects has been reported to fall with increased heart rates. 15,22 Therefore, the QTD response after exercise in hypertensives without LVH was similar to that of healthy subjects, indicating that only hypertension had no influence the QTD at rest or after exercise. The baseline QTD and QTaD values measured in hypertensives with LVH were similar to those in hypertensives without LVH.…”

Section: Discussionmentioning

confidence: 71%

“…In order to evaluate the effect of LVH on QTD and QTaD, we carefully ruled out the possibility of coronary artery disease from all subjects, because it has been reported that QTD and QTaD increase in patients with coronary artery diseases such as angina pectoris 4,14,15 and vasospastic angina. 16 In the present study, all subjects were subjected to coronary angiography and were diagnosed as having no significant coronary artery stenosis.…”

Section: Discussionmentioning

confidence: 99%

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Influence of Exercise on QT Dispersion in Hypertensive Patients With Left Ventricular Hypertrophy Without Coronary Artery Disease

Yoshimura¹,

Matsumoto²,

Watanabe³

et al. 1999

Jpn Circ J

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n hypertension, left ventricular hypertrophy (LVH) predicts an increased morbidity and mortality due to the occurrence of ventricular arrhythmias. 1,2 QT dispersion (QTD), which is defined as the difference between the maximum and minimum QT intervals occurring in any of the 12 leads of the electrocardiogram (ECG), is a reflection of the regional variation in ventricular repolarization and is believed to have predictive value in the assessment of the risk for ventricular arrhythmia. 3,4 An ECG at rest showing increased QTD has recently been reported to be a characteristic of hypertensives with LVH. 5,6 However, little is known about the QTD measured after exercise. Hypertension is a risk factor for coronary artery disease in patients who have been shown to have increased QTD. 4 When the effects of LVH in hypertension on QTD are evaluated, the effects of coronary artery disease, through which hypertension complicates QTD, should be excluded. To rule out coronary artery diseases completely, coronary angiography is desirable.We investigated the effect of exercise on QTD using the treadmill stress test in hypertensive patients with LVH who had undergone coronary angiography and had no coronary artery stenosis. Japanese Circulation Journal Vol.63, November 1999 Methods SubjectsWe studied 70 patients with essential hypertension (EH). Hypertension was defined as a systolic blood pressure of greater than 140 mmHg and/or diastolic blood pressure of more than 90 mmHg on at least 3 different occasions. All subjects underwent treadmill stress tests and coronary angiography. All of them showed negative exercise stress test results, defined by standard ST-segment depression criteria, and had no significant coronary artery stenosis or vasospasm. If the patients had taken antihypertensive drugs, the administration of these was stopped at least 2 weeks before the study. Subjects who had suffered a myocardial infarction, atrial fibrillation, or presented with bundle branch block were excluded. Approval for this study was obtained from the institution's Ethics Committee, and written informed consent was obtained from each subject. The 70 patients were divided into 2 groups on the basis of the echocardiographic measurement of their left ventricular mass index (LVMI). Hypertensive patients with LVH consisted of 7 men and 13 women; the hypertensives without LVH were 23 men and 27 women. Coronary AngiographyAll participants underwent coronary angiography and had no coronary artery disease, defined as one or more vessels with stenosis of 50% or more. Methylergometrine maleate (Novartis, Tokyo, Japan), dissolved in 20 ml of 0.9% saline, in incremental doses of 20 and 40 g, was injected over 2 min into the coronary artery to exclude vasospastic angina. A positive methylergometrine maleate Jpn Circ J 1999; 63: 881 -884 (Received June 18, 1999; revised manuscript received July 28, 1999; accepted August 9, 1999 In hypertensive patients with left ventricular hypertrophy (LVH), the influence of exercise on the regional variations in ventri...

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Section: Discussionsupporting

confidence: 92%

Section: Discussionmentioning

confidence: 71%

Section: Discussionmentioning

confidence: 99%

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Influence of Exercise on QT Dispersion in Hypertensive Patients With Left Ventricular Hypertrophy Without Coronary Artery Disease

Yoshimura¹,

Matsumoto²,

Watanabe³

et al. 1999

Jpn Circ J

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Exercise Update 2001

Stein

Chesler²,

Safi³

2001

Heart Disease

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Recent studies addressing the role of exercise in the detection, prevention, and treatment of coronary heart disease have significantly expanded our knowledge base in this area. This therapeutic review is focused on physiologic parameters in exercise, electrocardiogram testing, and the preventive impact of low-intensity regular exercise and the role of exercise training in selected patient populations.

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