Significance of glutathione S-transferase-π as a tumor marker in patients with oral cancer

Hirata, Shoji; Odajima, Tetsuyo; Kohama, Gen–iku; Ishigaki, Seishi; Niitsu, Yoshiro

doi:10.1002/1097-0142(19921115)70:10<2381::aid-cncr2820701002>3.0.co;2-9

Cited by 54 publications

(30 citation statements)

References 15 publications

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“…Moreover, the effects of CYP and GST polymorphisms on response were not observed to vary among the patients treated either with platinum and etoposide or platinum and other chemotherapeutics. These findings are likely to show that the studied CYP and GST polymorphisms are not functioning as a predictor of response to these two distinct platinum-based chemotherapy regimens, consisting of drugs among which namely cisplatin, carboplatin, etoposide and docetaxel are known substrates of especially GSTP1 enzyme [24,55,56], in advanced NSCLC patients. Our results are in line with those of Booton et al [39] who recently observed no association between the GSTP1 polymorphisms and platinum based treatment in advanced NSCLC patients [39].…”

Section: Discussionmentioning

confidence: 99%

CYP and GST polymorphisms and survival in advanced non-small cell lung cancer patients

Ada¹,

Kunak²,

Hancer³

et al. 2010

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Several polymorphisms in cytochrome P-450s (CYP)s and Glutathione S-transferases (GST)s have been reported to be associated with survival rates of patients with non-small cell lung cancer (NSCLC) but the studies in this regard are scarce and the results are contradictory. In this study, CYP1A1 (Ile462Val), CYP1B1(Asn453Ser), GST M1, GSTP1 exon 5 (Ile105Val) and exon 6(Ala114Val) and GSTT1 polymorphisms were determined in 138 patients with advanced NSCLC to evaluate their role in survival. Of the studied CYP and GST polymorphisms only GSTP1 exon 6 variant significantly altered (improved) the survival compared to wild type (p=0.036) with median survival of 22.2 months and 16.1 months, respectively. Multivariate analysis also revealed a significant reduction of adjusted hazard ratio of death associated only with the GSTP1 exon 6 variant genotype of 0.45 (95% confidence interval (95% CI), 0.23-0.89, p=0.022). These results show that the GSTP1 exon 6 variant genotype is associated with improved survival in the patients with advanced NSCLC.

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Section: Discussionmentioning

confidence: 99%

CYP and GST polymorphisms and survival in advanced non-small cell lung cancer patients

Ada¹,

Kunak²,

Hancer³

et al. 2010

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“…In node-negative breast cancer increased GST acidic isoenzyme measured immunohistochemically was associated with decreased disease-free survival and overall survival (Gilbert et al, 1993), but there was no correlation between the level of GST isoenzyme expression and the length of disease-free survival in nodepositive breast cancer when the isoenzymes were quantified by Western blot (Peters et al, 1993). In gastric cancer an immunohistochemical study showed no significant correlation between GST acidic isoenzyme expression and clinicopathological features or prognosis (Okuyama et al, 1994), but in oral cancer the acidic isoenzyme was considered to be a useful aid to early diagnosis, prediction of disease extent and outcome (Hirata et al, 1992). Immunohistochemical measurements of neutral isoenzymes have shown a positive correlation with survival in childhood acute lymphoblastic leukaemia (Hall et al, 1994), and of acidic isoenzymes with survival in non-lymphoblastic leukaemia in adults (Koberda and Hellman, 1994).…”

Section: Discussionmentioning

confidence: 99%

“…The glutathione transferase enzymes are a group of cytosolic proteins capable of catalysing detoxification pathways involved in the breakdown of a number of chemotherapeutic agents (Mannervik and Danielson, 1988). Certain of the isoenzymes have been implicated as markers of early disease recurrence in nodenegative breast cancer (i isoenzyme) (Gilbert et al, 1993), squamous cell oral cancer (x isoenzyme) (Hirata et al, 1992), childhood acute lymphoblastic leukaemia (y isoenzyme) (Hall et al, 1994) and acute non-lymphoblastic leukaemia (7x isoenzyme) (Tidefelt et al, 1992).…”

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confidence: 99%

Glutathione-S-transferase activity and isoenzyme levels measured by two methods in ovarian cancer, and their value as markers of disease outcome

Wrigley

McGown²,

Buckley³

et al. 1996

Br J Cancer

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Summary A study has been carried out to investigate the cellular distribution and levels of glutathione-Stransferase isoenzymes (GST), acidic (7t), basic (x) and neutral (p), in ovarian tumour biopsies, and to measure GST activity in the same tumour specimens. Two methods of assessing isoenzyme levels (immunohistochemistry and Western blot) were compared. Well-known important clinicopathological features were correlated with response to treatment, overall survival and progression-free survival for each of 97 patients from whom biopsies had been obtained. The glutathione-S-transferase isoenzyme levels were also correlated with overall and progression-free survival, and with the important clinicopathological features. As expected, there was a significant correlation between FIGO stage, histological grade of tumour, amount of residual disease after staging laparotomy, response to chemotherapy, and both overall and progression-free survival. Glutathione-Stransferase isoenzyme levels (acidic, basic and neutral) measured by Western blot were not found to be significantly correlated with any of the clinicopathalogical parameters tested. Using the immunohistochemistry method of detection there was a correlation between the GST acidic isoenzyme level and the amount of residual disease remaining after initial debulking surgery (higher levels were detected in the group with no residual disease, P=0.034), and also between the GST acidic isoenzyme level and the type of chemotherapy regimen used. Higher levels of the acidic isoenzyme were present in tumour biopsies taken from the patient group who had received a combination regimen (cyclophosphamide, carboplatin, ifosfamide and doxorubicin). The neutral and basic GST isoenzyme levels were not significantly correlated with any of the clinicopathalogical parameters. None of the GST isoenzyme levels were significantly correlated with response to treatment, overall survival or progression-free survival (using either method of detection). Similarly, glutathione transferase activity showed no significant correlation with prognosis or survival.

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“…Hirata et al 13 had observed similar increase in the GTT activity, though the study was done using plasma. Integration of all these observation strengthens our thinking that elevation of salivary GTT in precancerous and cancerous conditions can be a reliable biomarker in early detection and prevention of oral malignancy.…”

Section: Discussionmentioning

confidence: 99%

Study to assess Activity and Concentration of Gammaglutamyl Transpeptidase in Precancerous and Cancer Patients and Its Comparison with Controls

Farooqui

Thete

Bangi

et al. 2017

The Journal of Contemporary Dental Practice

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Objective: The purpose of the study is to highlight the use of gamma-glutamyl transpeptidase (GGT) as salivary enzyme tumor marker and assess the activity and concentration of GGT in precancerous and cancer patients and compare it with the normal control. Materials and methods:Individuals in the age group of above 20 years were included in the study. In this study, salivary GGT was analyzed in 75 cases. The selected patients were divided into three main groups as group I (controls with normal health), group II (patients with precancerous lesions and conditions), and group III (patients with oral cancer lesions). All the selected individuals were analyzed for salivary GGT.Results: A significant difference was observed between control and precancerous groups with GGT values at 5% level of significance. The mean GGT value is significantly higher in precancerous group as compared with control group (p < 0.05). A significant difference was observed between control and cancerous groups with GGT values at 5% level of significance. The mean GGT value is significantly higher in cancerous group as Conclusion:There is a remarkable increase in salivary GGT activity in both precancerous and cancerous conditions. The increased activity was more marked in cancerous conditions than in precancerous conditions. The GGT levels were two-to threefold increased in precancerous conditions as compared with control group. This finding was statistically significant and also suggested the strong correlation between GGT levels and presence of precancerous conditions. Clinical significance:Integration of all these observation strengthens our thinking that elevation of salivary GTT in precancerous and cancerous conditions can be a reliable biomarker in early detection and prevention of oral malignancy.

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Significance of glutathione S-transferase-π as a tumor marker in patients with oral cancer

Cited by 54 publications

References 15 publications

CYP and GST polymorphisms and survival in advanced non-small cell lung cancer patients

CYP and GST polymorphisms and survival in advanced non-small cell lung cancer patients

Glutathione-S-transferase activity and isoenzyme levels measured by two methods in ovarian cancer, and their value as markers of disease outcome

Study to assess Activity and Concentration of Gammaglutamyl Transpeptidase in Precancerous and Cancer Patients and Its Comparison with Controls

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