Significance of human papillomavirus positivity in sinonasal squamous cell carcinoma

Kılıç, Suat; Kim, Emilie S.; Baredes, Soly; Mahmoud, Omar; Gray, Stacey T.; Eloy, Jean Anderson

doi:10.1002/alr.21996

Cited by 61 publications

(53 citation statements)

References 46 publications

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“…In the past, sinonasal SCC has been linked to cigarette smoking and occupational exposures [ 7 ]. However, in recent years, the generational changes in sexual behavior may have led to an increased positivity rate for human papillomavirus (HPV) among patients with sinonasal SCC; consequently, HPV has been identified in 32–62% of all sinonasal SCCs [ 8 , 9 ]. HPV positivity is more common in SCCs of the nasal cavity than in paranasal SCCs [ 9 ].…”

Section: Sinonasal Malignanciesmentioning

confidence: 99%

“…However, in recent years, the generational changes in sexual behavior may have led to an increased positivity rate for human papillomavirus (HPV) among patients with sinonasal SCC; consequently, HPV has been identified in 32–62% of all sinonasal SCCs [ 8 , 9 ]. HPV positivity is more common in SCCs of the nasal cavity than in paranasal SCCs [ 9 ]. As with oropharyngeal SCCs, patients with a HPV-positive sinonasal SCC have a better prognosis than patients with a HPV-negative sinonasal SCC [ 8 , 9 ].…”

Section: Sinonasal Malignanciesmentioning

confidence: 99%

“…HPV positivity is more common in SCCs of the nasal cavity than in paranasal SCCs [ 9 ]. As with oropharyngeal SCCs, patients with a HPV-positive sinonasal SCC have a better prognosis than patients with a HPV-negative sinonasal SCC [ 8 , 9 ].…”

Section: Sinonasal Malignanciesmentioning

confidence: 99%

See 2 more Smart Citations

Imaging Characteristics of Malignant Sinonasal Tumors

Kawaguchi

Kato

Tomita

et al. 2017

JCM

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Malignancies of the nasal cavity and paranasal sinuses account for 1% of all malignancies and 3% of malignancies of the upper aerodigestive tract. In the sinonasal tract, nearly half of all malignancies arise in the nasal cavity, whereas most of the remaining malignancies arise in the maxillary or ethmoid sinus. Squamous cell carcinoma is the most common histological subtype of malignant tumors occurring in this area, followed by other epithelial carcinomas, lymphomas, and malignant soft tissue tumors. Although many of these tumors present with nonspecific symptoms, each tumor exhibits characteristic imaging features. Although complex anatomy and various normal variants of the sinonasal tract cause difficulty in identifying the origin and extension of large sinonasal tumors, the invasion of vital structures such as the brain, optic nerves, and internal carotid artery affects patients’ prognosis. Thus, diagnostic imaging plays a key role in predicting the histological subtype and in evaluating a tumor extension into adjacent structures. This article describes the computed tomography and magnetic resonance imaging findings for malignant sinonasal tumors.

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Section: Sinonasal Malignanciesmentioning

confidence: 99%

Section: Sinonasal Malignanciesmentioning

confidence: 99%

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Imaging Characteristics of Malignant Sinonasal Tumors

Kawaguchi

Kato

Tomita

et al. 2017

JCM

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“…20 Although the prognostic implications of HPV infection in SNSCC have not been fully elucidated, recent data suggest that HPV-associated SNSCC is more common in younger patients, occurs more often in the nasal cavity (as opposed to the paranasal sinuses), and is associated with better overall survival compared with HPVnegative tumors. 18,21,22 Morphologically, nonkeratinizing SNSCC is similar to nonkeratinizing squamous cell carcino- Figure 4. Benign entities in the differential diagnosis of sinonasal papillomas.…”

Section: Squamous Cell Carcinomamentioning

confidence: 99%

Sinonasal Papillomas and Carcinomas: A Contemporary Update With Review of an Emerging Molecular Classification

Weindorf

Brown

McHugh

et al. 2019

Archives of Pathology &Amp; Laboratory Medicine

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Context.— Sinonasal papillomas and carcinomas are uncommon head and neck neoplasms that comprise a broad clinicopathologic and morphologic spectrum, and thus frequently represent a diagnostic challenge for surgical pathologists. Recent molecular interrogation of these tumors has delineated a number of recurrent alterations that correspond to distinct entities with potential diagnostic and/or therapeutic clinical utility. Objective.— To summarize the salient clinicopathologic, morphologic, and molecular features of sinonasal papillomas and carcinomas. Data Sources.— Review of pertinent literature regarding sinonasal papillomas and sinonasal carcinomas. Conclusions.— Despite their relative rarity in many surgical pathology practices, sinonasal papillomas and carcinomas frequently demonstrate characteristic morphologic features that are important for accurate diagnosis. Given our emerging understanding of the molecular basis for these tumors, judicious use of available ancillary tools—including immunohistochemistry and in situ hybridization—may be helpful in subsets of cases, whereas additional molecular testing may be useful for diagnostically challenging and/or clinically aggressive sinonasal tumors.

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“…A prior institutional report demonstrated an apparent improved survival rate in human papillomavirus (HPV)‐positive sinonasal squamous cell carcinomas (SN‐SCCs), similar to what is seen in other head and neck cancers . The Rutgers group queried The National Cancer Database and demonstrated that and of 770 SN‐SCC cases identified, 244 (31.7%) were HPV‐positive. HPV positivity was more common in nasal cavity tumors than in sinus tumors, and was indeed associated with improved overall survival.…”

mentioning

confidence: 94%