1981
DOI: 10.1007/bf02593849
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Significance of hyperlactatemia in acute hypnotic drug poisoning

Abstract: Lactate concentration, fibrinogen and fibrin(ogen) -- degradation-products in central venous blood were analysed in 35 unconscious patient with acute hypnotic drug poisoning (HDP) and compared with the results in 13 healthy control persons undergoing the same degree of forced diuresis via central venous catheters. Blood samples were taken on admission and at 12 h intervals up to 36 h after admission. Patients with HDP were attributed to the categories of moderate intoxications (n = 17) and severe intoxications… Show more

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Cited by 2 publications
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“…Mechanisms to account for hyperlactatemia from specific drug overdoses are myriad and include the following: hypoperfusion because of vasoconstriction (e.g., ergots) 23 or hypotension (e.g., beta blockers); 24 muscle activity because of seizures (e.g., cocaine) 25 or myoclonus (e.g., serotonin syndrome); 26 altered metabolism of lactate because of increased production (e.g., propylene glycol) 27 or decreased clearance (e.g., metformin); 28 duration of unconsciousness; 5 mitochondrial DNA changes (e.g., nucleoside inhibitors); 29 and failure of cellular respiration because of poisoning of glycolysis (e.g., arsenic), 30 the Kreb’s cycle (e.g., monofluoroacetate), 31 electron transport (e.g., carbon monoxide), 32 or uncoupling of oxidative phosphorylation (e.g., salicylism). 33 …”
Section: Discussionmentioning
confidence: 99%
See 1 more Smart Citation
“…Mechanisms to account for hyperlactatemia from specific drug overdoses are myriad and include the following: hypoperfusion because of vasoconstriction (e.g., ergots) 23 or hypotension (e.g., beta blockers); 24 muscle activity because of seizures (e.g., cocaine) 25 or myoclonus (e.g., serotonin syndrome); 26 altered metabolism of lactate because of increased production (e.g., propylene glycol) 27 or decreased clearance (e.g., metformin); 28 duration of unconsciousness; 5 mitochondrial DNA changes (e.g., nucleoside inhibitors); 29 and failure of cellular respiration because of poisoning of glycolysis (e.g., arsenic), 30 the Kreb’s cycle (e.g., monofluoroacetate), 31 electron transport (e.g., carbon monoxide), 32 or uncoupling of oxidative phosphorylation (e.g., salicylism). 33 …”
Section: Discussionmentioning
confidence: 99%
“…5 Lactate concentration is a useful prognostic indicator for mortality in both medical and surgical patients including those with sepsis, 69 trauma, 1011 myocardial infarction with cardiogenic shock, 12 and in undifferentiated intensive care unit (ICU) patients. 13 Current guidelines for the initial approach to management of the patient with a drug overdose do not include routine evaluation of serum for a lactate concentration.…”
Section: Introductionmentioning
confidence: 99%