Significance of IgG4-positive cells in severe eosinophilic chronic rhinosinusitis

Koyama, Takahisa; Kariya, Shin; Sato, Yasuharu; Gion, Yuka; Higaki, Toru; Tamano, Haruna; Fujiwara, Tazuko; Minoura, Akira; Takao, Soshi; Orita, Yorihisa; Kanai, Kazuaki; Taniguchi, Masami; Nishizaki, Kazunori; Okano, Mitsuhiro

doi:10.1016/j.alit.2018.09.002

Cited by 30 publications

(18 citation statements)

References 36 publications

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“…This study showed that the number of IgG4-positive cells in the middle ear mucosa was significantly higher in patients with EOM than in those without EOM. This is the first report to demonstrate the presence of IgG4-positive cells in EOM, and the result is in consensus to that observed in the nasal mucosa in ECRS where the number of IgG4-positive plasma cells is significantly higher in patients with ECRS than without ECRS [7]. Although the role of IgG4 in EOM remains unclear, the results suggest IgG4 participation in EOM pathogenesis.…”

Section: Discussionsupporting

confidence: 87%

“…For example, we have reported that the number of IgG4-positive plasma cells is significantly higher in patients with eosinophilic chronic rhinosinusitis (ECRS), one of the typical type 2 inflammatory diseases, than in those with conventional non-ECRS. The local IgG4 expression is associated with disease severity and treatment outcome in chronic rhinosinusitis, especially ECRS [7].…”

Section: Introductionmentioning

confidence: 99%

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IgG4 Expression in Patients with Eosinophilic Otitis Media

Takahashi

Oka

Kariya

et al. 2021

ORL

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Objective: Eosinophilic otitis media (EOM) is an intractable middle ear disease recognized by an eosinophil enriched middle ear effusion and mucosa. Although precise pathogenesis of EOM remains unclear, it is characterized by type 2 inflammation. Since IgG4 is an IgG subclass induced by type 2 cytokines such as IL-4 and IL-13, we sought to characterize and compare local IgG4 expression in patients with and without EOM. Methods: Twelve patients with bilateral profound hearing loss, 9 of which underwent a cochlear implant surgery, were enrolled in this study (6 with EOM and 6 without EOM). The surgical specimens were harvested during surgery and were subjected to IgG4 immunostaining. Result: The middle ear mucosa showed the presence of a large number of IgG4-positive cells in patients with EOM, which was significantly higher than that in patients without EOM. Conclusion: Local IgG4 expression was observed in patients with EOM in comparison to those without EOM, suggesting that IgG4 contributes to EOM pathogenesis.

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Section: Discussionsupporting

confidence: 87%

Section: Introductionmentioning

confidence: 99%

IgG4 Expression in Patients with Eosinophilic Otitis Media

Takahashi

Oka

Kariya

et al. 2021

ORL

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“…In a recent study, it has been reported that IgG4-positive cells increase significantly in severe ECRS [24]. Particularly in allergic diseases, IgG4 is considered to act as a blocking agent for IgE antibodies induced by the antigen.…”

Section: Discussionmentioning

confidence: 99%

“…Seventy-one Japanese patients with CRS (47 males and 24 females; mean age, 55.8 years) were enrolled. Among these, 57 patients exhibited NP, and the remainder demonstrated no visible NP in the middle meatus (n = 14) [24]. Patients with CRSwNP were divided into non-ECRS (n = 27) and ECRS (n = 30) groups based on the Japanese Epidemiological Survey of Refractory Eosinophilic Chronic Rhinosinusitis (JESREC) criteria [5].…”

Section: Patientsmentioning

confidence: 99%

Clinical Significance of Cytoplasmic IgE-Positive Mast Cells in Eosinophilic Chronic Rhinosinusitis

Gion

Okano

Koyama

et al. 2020

IJMS

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Cross-linking of antigen-specific IgE bound to the high-affinity IgE receptor (FcεRI) on the surface of mast cells with multivalent antigens results in the release of mediators and development of type 2 inflammation. FcεRI expression and IgE synthesis are, therefore, critical for type 2 inflammatory disease development. In an attempt to clarify the relationship between eosinophilic chronic rhinosinusitis (ECRS) and mast cell infiltration, we analyzed mast cell infiltration at lesion sites and determined its clinical significance. Mast cells are positive for c-kit, and IgE in uncinated tissues (UT) and nasal polyps (NP) were examined by immunohistochemistry. The number of positive cells and clinicopathological factors were analyzed. Patients with ECRS exhibited high levels of total IgE serum levels and elevated peripheral blood eosinophil ratios. As a result, the number of mast cells with membranes positive for c-kit and IgE increased significantly in lesions forming NP. Therefore, we classified IgE-positive mast cells into two groups: membrane IgE-positive cells and cytoplasmic IgE-positive cells. The amount of membrane IgE-positive mast cells was significantly increased in moderate ECRS. A positive correlation was found between the membrane IgE-positive cells and the radiological severity score, the ratio of eosinophils, and the total serum IgE level. The number of cytoplasmic IgE-positive mast cells was significantly increased in moderate and severe ECRS. A positive correlation was observed between the cytoplasmic IgE-positive cells and the radiological severity score, the ratio of eosinophils in the blood, and the total IgE level. These results suggest that the process of mast cell internalization of antigens via the IgE receptor is involved in ECRS pathogenesis.

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“…This antibody is known to block the response mediated by IgE antibody against allergens, but its clinical significance remains to be clarified. 7 Regarding changes in the cedar allergen-specific IgG4 level during SLIT, according to a comparative study using a drug and a placebo, the IgG4 level in the drug-treated group increased after the start of treatment, and transiently decreased after the pollen dispersion period, but then later increased again. In the placebo group, the changes were slight.…”

Section: Discussionmentioning

confidence: 99%

Preliminary Clinical Trial of Biomarkers to Predict Response to Sublingual Immunotherapy for Japanese Cedar Pollinosis

et al. 2020

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Background: As part of the planning for a future multicenter study, this preliminary clinical trial was performed to explore candidate biomarkers useful for predicting the therapeutic effects of sublingual immunotherapy (SLIT) for Japanese cedar pollinosis (JCP) using serum samples from patients.Methods: This prospective study included patients undergoing SLIT for JCP at our hospital. All enrolled patients (n = 17) started SLIT between June and November of 2015. With informed consent from the patients, in January, March, and June of 2016, blood samples were obtained, and an inquiry was conducted using the Japan rhinoconjunctivitis quality of life questionnaire (JRQLQ). Based on the JRQLQ results, we allocated 6 patients with the most favorable results into the high response group (HRG), and 5 patients with the most unfavorable results into the poor response group (PRG). Subsequently, we compared the serum data between the two groups to identify useful biomarkers.Results: The IL-12p70 and VEGF levels tended to be higher in the HRG than in the PRG in January, March and June (0.10 > p > 0.05). In addition, the IL-17 level was significantly higher (p < 0.05) in the HRG than in the PRG only in June.Conclusions: IL-12p70 and VEGF may be useful biomarkers for predicting the effects of SLIT. In addition, although it does not appear to be useful as a biomarker for evaluating treatment response at the start of SLIT, IL-17 may be useful as a biomarker after the beginning period of SLIT.

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Significance of IgG4-positive cells in severe eosinophilic chronic rhinosinusitis

Cited by 30 publications

References 36 publications

IgG4 Expression in Patients with Eosinophilic Otitis Media

IgG4 Expression in Patients with Eosinophilic Otitis Media

Clinical Significance of Cytoplasmic IgE-Positive Mast Cells in Eosinophilic Chronic Rhinosinusitis

Preliminary Clinical Trial of Biomarkers to Predict Response to Sublingual Immunotherapy for Japanese Cedar Pollinosis

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