Significance of inflammation-based indices in the prognosis of patients with non-metastatic colorectal cancer

Song, Xiangping; Zhu, Hong; Pei, Qian; Tan, Fengbo; Li, Chenglong; Zhou, Zhongyi; Zhou, Yuan; Yu, Nanhui; Li, Yuqiang; Pei, Haiping

doi:10.18632/oncotarget.16774

Cited by 34 publications

(36 citation statements)

References 41 publications

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“…Our most interesting finding is the demonstration of prognostic significance of higher values of PDW on admission in internal medicine wards. Higher PDW levels have recently been reported to be associated with increased morbidity and mortality in numerous clinical investigations that focused on patients with critical illness [11,13], and with specific acute and chronic disorders [10,[14][15][16][17][18][19][20][21][22][23]. We observed that PDW values above the cut-off of 16.7% at admission, as well as above the normal range, were associated with an increased risk of mechanical ventilation and death during the current hospitalization, and shortened survival following discharge.…”

Section: Discussionmentioning

confidence: 52%

“…Increased PDW values have been reported in patients with diabetes mellitus [5], cancer [6,7], and cardiocerebrovascular and respiratory disorders [8][9][10][11][12]. Moreover, higher PDW levels have recently been reported to be associated with increased morbidity and mortality among patients with critical illness [11,13], coronary artery disease [14][15][16][17], cancer [18][19][20][21], pulmonary embolism [10,22], and chronic obstructive pulmonary disease [23]. Most previous studies on the clinical significance of PDW involved patients with specific disorders.…”

Section: Introductionmentioning

confidence: 99%

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Platelet distribution width: a novel prognostic marker in an internal medicine ward

Tzur

Barchel

Izhakian

et al. 2019

Journal of Community Hospital Internal Medicine Perspectives

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Background: Platelet distribution width (PDW) has demonstrated clinical significance in populations with specific disorders; its prognostic significance in internal medicine wards has not been investigated. Methods: Demographic, clinical and laboratory data were collected prospectively for 1036 internal medicine inpatients. The primary outcome was 90-day mortality, secondary outcomes were: treatment with mechanical ventilation, prolonged hospital stay, in-hospital death, and all-cause mortality following discharge. Data were assessed according to PDW values on admission ≤16.7% (group A) and >16.7% (group B). Results: Compared to group A patients (n = 273), group B patients (n = 763) were more likely to be older, admitted for cardio-cerebrovascular disorder, to present with comorbidities, to be mechanically ventilated, to have prolonged hospital stay and to die during the current hospitalization. The respective 90-day and total (median follow-up of 5 months) mortality rates were significantly higher in group B (13.2% and 16.3%) than in group A (6.6% and 9.5%), P < 0.01. On multivariate analysis, higher PDW values on admission predicted 90-day mortality and shortened survival (relative risks 1.58 and 1.26; 95% confidence intervals 0.89 − 2.78 and 0.97-1.64, respectively). Conclusion: Higher PDW values on admission to internal medicine wards are associated with a more severe clinical profile and increased risk of 90-day mortality.

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Section: Discussionmentioning

confidence: 52%

Section: Introductionmentioning

confidence: 99%

Platelet distribution width: a novel prognostic marker in an internal medicine ward

Tzur

Barchel

Izhakian

et al. 2019

Journal of Community Hospital Internal Medicine Perspectives

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“…Inflammation is an essential component of the tumour microenvironment, and the changes in inflammatory cells might influence tumour progression, such as neoplastic cell proliferation, migration, invasion, collapse of anti-tumour immunity, metastasis, and so forth [5,6]. Accumulating evidence shows that the peripheral neutrophil-to-lymphocyte ratio (NLR) and the platelet-to-lymphocyte ratio (PLR) have been widely proposed as prognostic factors for many malignancies such as gastric cancer [7], nasopharyngeal carcinoma [8], liver cancer [9], and especially colorectal cancer [10]. Moreover, it is likely that the tumour microenvironment as well as systemic inflammatory response might be changed because of surgery [11].…”

Section: Introductionmentioning

confidence: 99%

Perioperative changes of inflammation-based biomarker for predicting the prognosis in colorectal cancer patients: a retrospective analysis

Wang

Yan

et al. 2019

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Introduction: Perioperative inflammatory markers, including the neutrophil-lymphocyte ratio (NLR) and platelet-lymphocyte ratio (PLR), are associated with oncological prognosis. However, their changes in colorectal cancer surgery for predicting the prognosis are rarely investigated. Aim: To compare perioperative changes to evaluate the prognostic significance of patients' survival. Material and methods: Retrospective clinical data and baseline laboratory parameters of 183 colorectal cancer (CRC) patients who underwent curative surgery were collected between January 2007 and January 2013. The clinicopathological characteristics were compared. Statistical analysis was used to identify the predictive changes of perioperative NLR and PLR associated with survival prognosis. Results: ROC analysis indicated that perioperative NLR/PLR showed higher predictive accuracy for prognosis, and the optimal cutoff values of pre-NLR, post-NLR, pre-PLR, and post-PLR were 2.94, 4.32, 184.29, and 212.37, respectively. Kaplan-Meier analysis suggested that the four groups stratified by perioperative changes had significantly different recurrence-free survival and overall survival (p < 0.05). Univariate and multivariable analysis revealed that patients with higher cancer stage, lymph node metastasis, and perioperative change of NLR/PLR (HH, LH) had significant association with poor prognosis of RFS and OS (all p < 0.05). Conclusions: Perioperative NLR and PLR might be good predictors for prognosis in CRC patients who have undergone curative surgery, which could guide the customised therapeutic strategy. Furthermore, their assessment could contribute to accurately predicting oncologic outcomes and provide an in-depth understanding of the patients, which could guide the operational strategy.

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“…Lately, there is a growing interest of the host's inflammatory response against the tumor. Several studies have proposed NLR, PLR, and TPC as indicators of inflammatory conditions, and these indicators were described as both prognostic and predictive biomarkers in some cancers (Monreal et al, 1998;Forget et al, 2013;Lee et al, 2013;Pedrazzani et al, 2017;Song et al, 2017;Zhang et al, 2017a).…”

Section: Discussionmentioning

confidence: 99%

Effect of Pretreatment Platelet Parameters on Survival in Limited Disease Small Cell Lung Cancer

Sakin

Yaşar

Arıcı

et al. 2019

Asian Pac J Cancer Prev

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Background:The aim of this study was to investigate the effect of platelet parameters before concurrent chemoradiotherapy (CCRT) on survival of patients with limited disease small cell lung cancer (LD-SCLC). Methods: This study consisted of patients who received CCRT due to LD-SCLC in the oncology clinic between 1997-2017. Examined platelet parameters included total platelet count (TPC), mean platelet volume, platelet distribution width, and platelet-lymphocyte ratio. The cut-off value for TPC was determined as 306x10 9 /U (sensitivity: 62%, specificity: 75.5%), where patients below or equal to this level was classified as Group I, and those above as Group II. Results:The study included 90 patients whose mean age was 59 years (range: 42-83) and male ratio was 80.0% (n=72). Near three-fourths of patients (74.4%) were at clinical stage III. Among stage I-II patients, mOS was found as 126 months for Group I whereas it had not been reached in Group II (p=0.158). Stage III patients showed significantly lower mOS for Group 1 (16 [range: 14.1-17.8] months) compared to that in Group 2 (19.0 [range: 15.6-62.8] months; p=0.002). In multivariate analysis, Eastern Cooperative Oncology Group performance score (p=0.003), clinical stage (p<0.001), prophylactic cranial irradiation (p=0.004), and TPC (p=0.031) was determined as the most significant factors affecting survival. Conclusion: Our study suggests association of high baseline levels of TPC to improved survival in patients scheduled to undergo CCRT for LD-SCLC. Considering easiness and universal availability of TPC measurement, potential utilization of this biomarker may be promising to predict survival, albeit requiring validation by further well-designated prospective studies.

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Significance of inflammation-based indices in the prognosis of patients with non-metastatic colorectal cancer

Cited by 34 publications

References 41 publications

Platelet distribution width: a novel prognostic marker in an internal medicine ward

Platelet distribution width: a novel prognostic marker in an internal medicine ward

Perioperative changes of inflammation-based biomarker for predicting the prognosis in colorectal cancer patients: a retrospective analysis

Effect of Pretreatment Platelet Parameters on Survival in Limited Disease Small Cell Lung Cancer

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