Significance of Interleukin-6 in Papillary Thyroid Carcinoma

Kobawala, Toral P; Trivedi, Trupti; Gajjar, Kinjal; Patel, Devendra D.; Patel, Girish H.; Ghosh, Nandita

doi:10.1155/2016/6178921

Cited by 36 publications

(53 citation statements)

References 72 publications

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“…We cannot therefore draw conclusions on whether adiponectin plays a role in TC in addition to or independently of excess weight. A number of relatively small studies have compared levels of leptin, circulating cytokines, including IL‐1β, IL‐5, IL‐6, IL‐7, IL‐8, IL‐9, IL‐10, IL‐13, TNF‐α, IFN‐γ and CRP, among TC cases and controls but results were not consistent across studies . In prediagnostic samples, we observed no significant associations with leptin, CRP, IL‐6 and TNF‐α.…”

Section: Discussioncontrasting

confidence: 83%

Adipokines and inflammation markers and risk of differentiated thyroid carcinoma: The EPIC study

Dossus

Franceschi

Biessy

et al. 2017

Intl Journal of Cancer

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Other than the influence of ionizing radiation and benign thyroid disease, little is known about the risk factors for differentiated thyroid cancer (TC) which is an increasing common cancer worldwide. Consistent evidence shows that body mass is positively associated with TC risk. As excess weight is a state of chronic inflammation, we investigated the relationship between concentrations of leptin, adiponectin, C-reactive protein, interleukin (IL)-6, IL-10 and tumor necrosis factor (TNF)-a and the risk of TC. A case-control study was nested within the European Prospective Investigation into Cancer and Nutrition (EPIC) study and included 475 first primary incident TC cases (399 women and 76 men) and 1,016 matched cancer-free cohort participants. Biomarkers were measured in serum samples using validated and highly sensitive commercially available immunoassays. Odds ratios (ORs) of TC by levels of each biomarker were estimated using conditional logistic regression models, adjusting for BMI and alcohol consumption. Adiponectin was inversely associated with TC risk among women (OR T3vs.T1 5 0.69, 95% CI: 0.49-0.98, P trend 5 0.04) but not among men (OR T3vs.T1 5 1.36, 95% CI: 0.67-2.76, P trend 5 0.37). Increasing levels of IL-10 were positively associated with TC risk in both genders and significantly so in women (OR T3vs.T1 5 1.59, 95% CI: 1.13-2.25, P trend 5 0.01) but not in men (OR T3vs.T1 5 1.78, 95% CI: 0.80-3.98, P trend 5 0.17). Leptin, CRP, IL-6 and TNF-a were not associated with TC risk in either gender. These results indicate a positive association of TC risk with IL-10 and a negative association with adiponectin that is probably restricted to women. Inflammation may play a role in TC in combination with or independently of excess weight.

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Section: Discussioncontrasting

confidence: 83%

Adipokines and inflammation markers and risk of differentiated thyroid carcinoma: The EPIC study

Dossus

Franceschi

Biessy

et al. 2017

Intl Journal of Cancer

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“…2). The cytokines IL-6 and IL-8 are involved in angiogenesis and progression in different cancer types [52-54]. On the RPM, their genes were up-regulated significantly after 4 h in RPM-AD cells.…”

Section: Discussionmentioning

confidence: 99%

Cytokine Release and Focal Adhesion Proteins in Normal Thyroid Cells Cultured on the Random Positioning Machine

Warnke

Pietsch

Kopp

et al. 2017

Cell Physiol Biochem

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Background/Aims: Spaceflight impacts on the function of the thyroid gland in vivo. In vitro normal and malignant thyrocytes assemble in part to multicellular spheroids (MCS) after exposure to the random positioning machine (RPM), while a number of cells remain adherent (AD). We aim to elucidate possible differences between AD and MCS cells compared to 1g-controls of normal human thyroid cells. Methods: Cells of the human follicular epithelial thyroid cell line Nthy-ori 3-1 were incubated for up to 72 h on the RPM. Afterwards, they were investigated by phase-contrast microscopy, quantitative real-time PCR and by determination of cytokines released in their supernatants. Results: A significant up-regulation of IL6, IL8 and CCL2 gene expression was found after a 4h RPM-exposure, when the whole population was still growing adherently. MCS and AD cells were detected after 24 h on the RPM. At this time, a significantly reduced gene expression in MCS compared to 1g-controls was visible for IL6, IL8, FN1, ITGB1, LAMA1, CCL2, and TLN1. After a 72 h RPM-exposure, IL-6, IL-8, and TIMP-1 secretion rates were increased significantly. Conclusion: Normal thyrocytes form MCS within 24 h. Cytokines seem to be involved in the initiation of MCS formation via focal adhesion proteins.

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“…1. Eighteen of these 29 studies are published in Chinese [14][15][17][18][19][20][21][22][23][24][25][26][27][28][29][30][31][32] and the rest are published in English [33][34][35][36][37][38][39][40][41]. Nineteen studies were conducted in China, two in India and two in Turkey.…”

Section: Search Results and Characteristics Of Included Studiesmentioning

confidence: 99%

“…Of the 29 included studies, 9 reported the level of serum IL-6 in patients with thyroid carcinoma and control subjects [20,23,28,32,[35][36]38,[40][41]. Due to the large heterogeneity of the merged SMD 7 values of serum IL-6 level by the heterogeneity analysis (heterozygosity test, Chi 2 =334.36, P<0.00001, I 2 = 96%), random-effect model was used to pooled the SMD values, and the pooled effect size in favor of control subjects is 1.04 (95% CI 0.40 to 1.67, P=0.001) ( Fig.…”

Section: Il-6 and Thyroid Carcinomamentioning

confidence: 99%

Association between adipokines and thyroid carcinoma: a meta-analysis of case-control studies

Zhao

Wen

Wang

et al. 2020

Preprint

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Background: The incidence of thyroid carcinoma is on the rise all the world. Some studies have suggested that the change of adipokines can even induce thyroid carcinoma. However, other studies have come to the opposite conclusion. Therefore, we studied the relationship between adipokines and thyroid carcinoma. Methods: Databases—PubMed, Cochrane Library, SinoMed, CNKI, Wanfang, and clinical trial registries were searched. A meta-analysis was performed with sufficiently homogeneous studies. Twenty-nine articles were finally included for analysis. Results: The level of serum tumor necrosis factor-alpha (TNF-α) [standardized mean difference (SMD) =1.31, 95% confidence interval (95% CI): 0.35 to 2.28, I 2 =98%, P =0.008] and positive rate of tissue’s TNF-α [odds ratios (OR) =11.80, 95% CI: 5.88 to 23.66, I 2 =0%， P <0.00001] in thyroid carcinoma are significantly higher than those in control. The serum interleukin-6 (IL-6) in patients with thyroid carcinoma is higher than that in control (SMD=1.04, 95% CI: 0.40 to 1.67, I 2 =96%, P =0.001). No significant difference of the positive rate of IL-6 in tissues between carcinoma and control is found (OR=1.23, 95% CI: 0.62 to 2.43, I 2 =86%, P =0.55). The positive ratio of leptin in tissue is significantly associated with the risk of thyroid carcinoma (OR=12.21, 95% CI: 3.36 to 44.40, I 2 =85%, P <0.00001). However, after analyzing three studies on the expression of adiponectin, no significant difference is found in serum adiponectin level between thyroid carcinoma and the control ( P =0.81). Conclusions: Adipokines play an important role in the occurrence and development of thyroid carcinoma, especially TNF-α, IL-6 and leptin. However, the effect of adiponectin on thyroid carcinoma needs further research.

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Significance of Interleukin-6 in Papillary Thyroid Carcinoma

Cited by 36 publications

References 72 publications

Adipokines and inflammation markers and risk of differentiated thyroid carcinoma: The EPIC study

Adipokines and inflammation markers and risk of differentiated thyroid carcinoma: The EPIC study

Cytokine Release and Focal Adhesion Proteins in Normal Thyroid Cells Cultured on the Random Positioning Machine

Association between adipokines and thyroid carcinoma: a meta-analysis of case-control studies

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