Significance of Interleukin (IL)-4 and IL-13 in Inflammatory Arthritis

Iwaszko, Milena; Biały, Sylwia; Bogunia‐Kubik, Katarzyna

doi:10.3390/cells10113000

Cited by 153 publications

(100 citation statements)

References 182 publications

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“…IL-4 and IL-13 are typical Th 2 cytokines; the former influences the secretion of IgE, while the latter can aggravate allergic reactions [ 18 ]. IFN-γ is a Th1 cytokine, and the main mechanism of allergen-specific immunotherapy is the transfer of Th2 cell response to Th1 cell response [ 19 ].…”

Section: Resultsmentioning

confidence: 99%

“…As is universally accepted, the internal profile of the Th1/Th2 reaction determines the direction of antibody response. IL-4 is a Th2 cytokine, which plays an important role in promoting B-cell proliferation and stimulating B cells to secrete IgE [ 18 ]. In the supernatant of the spleen-cell culture in vitro, the secretion of IL-4 in mice treated with rAmb a 1-loaded PLGA-PEG nanoparticles was significantly inhibited.…”

Section: Discussionmentioning

confidence: 99%

“…These results are consistent with our previous studies. Similar to IL-4, IL-13 plays an important role in the induction and maintenance of Th2 cellular immune response [ 18 , 29 ]. The decrease in IL-13 in the rAmb a1-loaded PLGA-PEG nanoparticle treatment group also shows that the ratio of Th1/Th2 increases and the allergic reaction is reduced.…”

Section: Discussionmentioning

confidence: 99%

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Effects of rAmb a 1-Loaded PLGA-PEG Nanoparticles in a Murine Model of Allergic Conjunctivitis

et al. 2022

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Ambrosia artemisiifolia (Amb a) contains many allergens. Allergic conjunctivitis caused by Ambrosia artemisiifolia and its related allergen-specific immunotherapy (AIT) are seldom studied at present. poly(DL-lactide-co-glycolide)-polyethylene glycol (PLGA-PEG) is a very good nano-carrier, which has been applied in the medical field. In this context, we studied the immunotherapy effect and potential mechanism of recombinant Amb a 1 (rAmb a 1)-loaded PLGA-PEG nanoparticles. A mouse allergic conjunctivitis model was established with Ambrosia artemisiifolia crude extract, and the nanoparticles were used for AIT through direct observation of conjunctival tissue, degranulation of mast cells in conjunctival tissue, serum-specific antibodies, cytokines and other assessment models. The treatment of nanoparticles enhanced the secretion of T-helper 1 (Th1) cytokine Interferon-gama (IFN-γ) and the production of immunoglobulin G (IgG)2a (IgG2a), inhibited the secretion of T-helper 2 (Th2) cytokine Interleukin (IL)-13 and IL-4 and the level of IgE. Especially, degranulation of mast cells and expression of mast cell protease-1 (MCP-1) in conjunctival tissue was reduced significantly. In this study, we proved that the nanoparticles prepared by rAmb a 1 and PLGA-PEG have an immunotherapy effect on allergic conjunctivitis in mice.

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Section: Resultsmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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Effects of rAmb a 1-Loaded PLGA-PEG Nanoparticles in a Murine Model of Allergic Conjunctivitis

et al. 2022

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“…Furthermore, Th2 immunity is also indispensable for host immunity to combat Eimeria parasites ( 67 ). IL-4 is predominantly generated by CD4 + Th2 cells and CD4 + follicular helper T (Tfh) cells ( 68 ). Enhanced IL-4 levels were observed in the current research, indicating that rEm1a-loaded vaccines might activate Th2-related and Tfh-related immunity.…”

Section: Discussionmentioning

confidence: 99%

PLGA Nanospheres as Delivery Platforms for Eimeria mitis 1a Protein: A Novel Strategy to Improve Specific Immunity

et al. 2022

Front. Immunol.

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The infections of chicken coccidiosis impact the welfare of chickens and the economical production of poultry. Eimeria mitis is ubiquitous in chicken coccidiosis, and E. mitis infection can significantly affect the productivity of birds. Up to now, few efficient vaccines against E. mitis have been reported, whereas the recombinant subunit vaccines delivered by nanomaterials may elicit an encouraging outcome. Thus, in this study, we chose E. mitis 1a (Em1a) protein as the candidate antigen to generate Em1a preparations. The recombinant Em1a (rEm1a) protein was encapsulated with poly lactic-co-glycolic acid (PLGA) and chitosan (CS) nanospheres. The physical characterization of the rEm1a-PLGA and rEm1a-CS nanospheres was investigated, and the resulting nanospheres were proven to be nontoxic. The protective efficacy of rEm1a-PLGA and rEm1a-CS preparations was evaluated in E. mitis-challenged birds in comparison with two preparations containing rEm1a antigen emulsified in commercially available adjuvants. ELISA assay, flow cytometry analysis, and quantitative real-time PCR (qPCR) analysis indicated that vaccination with rEm1a-loaded nanospheres significantly upregulated the secretions of antibodies and cytokines and proportions of CD4+ and CD8+ T lymphocytes. Compared with the other three preparations, rEm1a-PLGA nanosphere was more effective in improving growth performance and inhibiting oocyst output in feces, indicating that the PLGA nanosphere was associated with optimal protection against E. mitis. Collectively, our results highlighted the advantages of nanovaccine in eliciting protective immunity and may provide a new perspective for developing effective vaccines against chicken coccidiosis.

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“…The IL-4/IL-13 axis also plays important roles in the pathophysiology of inflammatory arthritis especially rheumatoid arthritis (RA). In RA, IL-4/IL-13 cytokines promote the production of proinflammatory cytokines such as IL-1β and TNF-α, as well as macrophage polarization from classically activated (M1) phenotype into the alternatively activated (M2) phenotype ( Iwaszko, Biały & Bogunia-Kubik, 2021 ). These collectively promote inflammation of the joints in RA patients.…”

Section: Survey Methodologymentioning

confidence: 99%

IL-4/IL-13 axis as therapeutic targets in allergic rhinitis and asthma

Husna

Shukri

Ashari

et al. 2022

PeerJ

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Allergic rhinitis (AR) is a common disorder of the upper airway, while asthma is a disease affecting the lower airway and both diseases are usually comorbid. Interleukin (IL)-4 and IL-13 are critical cytokines in the induction of the pathogenic Th2 responses in AR and asthma. Targeting the IL-4/IL-13 axis at various levels of its signaling pathway has emerged as promising targeted therapy in both AR and asthma patient populations. In this review, we discuss the biological characteristics of IL-4 and IL-13, their signaling pathways, and therapeutic antibodies against each cytokine as well as their receptors. In particular, the pleiotropic roles of IL-4 and IL-13 in orchestrating Th2 responses in AR and asthma patients indicate that dual IL-4/IL-13 blockade is a promising therapeutic strategy for both diseases.

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Significance of Interleukin (IL)-4 and IL-13 in Inflammatory Arthritis

Cited by 153 publications

References 182 publications

Effects of rAmb a 1-Loaded PLGA-PEG Nanoparticles in a Murine Model of Allergic Conjunctivitis

Effects of rAmb a 1-Loaded PLGA-PEG Nanoparticles in a Murine Model of Allergic Conjunctivitis

PLGA Nanospheres as Delivery Platforms for Eimeria mitis 1a Protein: A Novel Strategy to Improve Specific Immunity

IL-4/IL-13 axis as therapeutic targets in allergic rhinitis and asthma

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