Significance of Interviral Recombination as Novel Mechanism for Extending Viral Disease Repertoire

Johnson, Edward M.; Daniel, Dianne C.

doi:10.4172/2168-975x.1000217

Cited by 2 publications

(2 citation statements)

References 9 publications

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“…Viruses are shown to co-circulate within a community leading to co-infections 6 – 9 and may result in the emergence of new viruses through possible reassortment or recombination 10 – 13 . These novel viruses could have the potential to cause new virus disease with little prophylaxis or therapy to counteract, thus becoming a One-Health concern.…”

Section: Introductionmentioning

confidence: 99%

Metagenomic characterisation of avian parvoviruses and picornaviruses from Australian wild ducks

Vibin,

Chamings,

Klaassen

et al. 2020

Sci Rep

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Ducks can shed and disseminate viruses and thus play a role in cross-species transmission. In the current study, we detected and characterised various avian parvoviruses and picornaviruses from wild Pacific black ducks, Chestnut teals, Grey teals and Wood ducks sampled at multiple time points from a single location using metagenomics. We characterised 46 different avian parvoviruses belonging to three different genera Dependoparvovirus, Aveparvovirus and Chaphamaparvovirus, and 11 different avian picornaviruses tentatively belonging to four different genera Sicinivirus , Anativirus , Megrivirus and Aalivirus . Most of these viruses were genetically different from other currently known viruses from the NCBI dataset. The study showed that the abundance and number of avian picornaviruses and parvoviruses varied considerably throughout the year, with the high number of virus reads in some of the duck samples highly suggestive of an active infection at the time of sampling. The detection and characterisation of several parvoviruses and picornaviruses from the individual duck samples also suggests co-infection, which may lead to the emergence of novel viruses through possible recombination. Therefore, as new and emerging diseases evolve, it is relevant to explore and monitor potential animal reservoirs in their natural habitat.

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Section: Introductionmentioning

confidence: 99%

Metagenomic characterisation of avian parvoviruses and picornaviruses from Australian wild ducks

Vibin,

Chamings,

Klaassen

et al. 2020

Sci Rep

View full text Add to dashboard Cite

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“…Although JCV sequence insertions, deletions, and rearrangements are associated with neurovirulent transformation and latent virus reactivation, triggers that initiate these changes are not well understood. Funded work examined the process of neurovirulence, with an aim of identifying points for intervention to prevent, halt, or repair sequence alterations [4, 6, 7]. Grants also examined consequences of sequence mutations on JCV replication and viral assembly to understand the mechanism of pathogenesis and identify potential therapeutic targets for treating JCV infection What factors might help to stratify individuals with increased risk of PML?…”

Section: The Consortium’s Activities: Driving Research and Dialogue Omentioning

confidence: 99%

The Progressive Multifocal Leukoencephalopathy Consortium as a Model for Advancing Research and Dialogue on Rare Severe Adverse Drug Reactions

Peterson¹,

Iverson

Kasaian

et al. 2019

Adv Ther

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Progressive multifocal leukoencephalopathy (PML) is a rare but serious disease. Caused by the JC virus (JCV), it occurs in individuals with weakened immune systems and is a potential adverse reaction for certain immunomodulatory drugs. The PML Consortium was created to find better methods to predict, prevent, and treat PML. The Consortium brought together the pharmaceutical industry with academic, regulatory, and patient communities to advance research and dialogue on PML through a not-for-profit, collaborative approach involving a grant program, scientific workshops and conferences, and disease awareness efforts. Over nearly a decade, the Consortium contributed to the PML and JCV fields by advancing research, scientific exchange, and awareness of PML. In addition to advancing knowledge and helping to build cross-sector consensus on research priorities, the Consortium’s grant program filled a funding gap and brought new investigators into PML and JCV research. Additionally, the Consortium’s workshops and conferences created platforms for exchange that drove dialogue on knowledge gaps and future research directions. The Consortium also contributed to the scientific knowledge base with two literature reviews, one on PML treatment studies and a second on T cell deficiencies as a risk factor for PML and the brain as a site for conversion of harmless JCV into a pathogenic virus. Finally, the Consortium addressed a significant information gap with its disease awareness website for healthcare professionals, patients, and caregivers. Beyond its impact on the PML and JCV fields, the PML Consortium is important because it provides a precedent for how the pharmaceutical industry, academic researchers, patient organizations, and government can work together to address rare diseases, in particular rare adverse events. This kind of collaboration could be replicated to speed progress in addressing other rare diseases and adverse events, with significant potential benefits for the scientific, medical, and patient communities.FundingPML Consortium (PML Consortium, Washington, DC).

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Significance of Interviral Recombination as Novel Mechanism for Extending Viral Disease Repertoire

Cited by 2 publications

References 9 publications

Metagenomic characterisation of avian parvoviruses and picornaviruses from Australian wild ducks

Metagenomic characterisation of avian parvoviruses and picornaviruses from Australian wild ducks

The Progressive Multifocal Leukoencephalopathy Consortium as a Model for Advancing Research and Dialogue on Rare Severe Adverse Drug Reactions

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