Significance of Kampo, Traditional Japanese Medicine, in Supportive Care of Cancer Patients

Yamakawa, J; Motoo, Yoshiharu; Moriya, Junji; Ogawa, Michio; Uenishi, Hiroaki; Akazawa, Sumiyo; Sasagawa, Toshiyuki; Nishio, Matomo; Kobayashi, Junji

doi:10.1155/2013/746486

Cited by 17 publications

(9 citation statements)

References 85 publications

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“…Here we focused on Japanese traditional herbal medicine (Kampo) as an immune adjuvant for tumor vaccine. Currently, Kampo is used in a number of clinical situations such as cancer therapy, and contributes to health care (23)(24)(25)(26)(27)(28).…”

Section: Discussionmentioning

confidence: 99%

Immune adjuvant effect of Juzentaihoto, a Japanese traditional herbal medicine, on tumor vaccine therapy in a mouse model

Takeno

Inujima

Shinohara

et al. 2015

International Journal of Oncology

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Japanese traditional herbal medicine (Kampo) have been used to improve the general physical condition after surgery and to mitigate the side effects of radiation and chemotherapy in tumor patients. Juzentaihoto (JTT) consists of ten medical herbs, and is also called Shi-Quan-Da-Bu-Tang in Chinese herbal medicine. Among Kampo medicines, JTT has especially gained attention as a biological response modifier. Currently, clinical trials of various tumor vaccine therapies are being performed world-wide. However, tumor antigens that are inoculated as vaccines do not have high immunogenicity; thus, it is difficult to obtain an effective therapeutic effect. Thus, it is necessary to develop a tumor vaccine adjuvant that is more potent and very safe. In the present study, we examined the efficacy of JTT as an oral adjuvant when given together with tumor vaccines. As a result, JTT enhanced the phagocytic ability of OVA antigen and the presentation ability of OVA antigen in dendritic cells in vitro. Furthermore, tumor growth was markedly decreased, and the survival period was significantly prolonged in mice inoculated with mouse lymphoma, which is expressed with tumor model antigen. In conclusion, these findings suggest that JTT can be used with tumor vaccines as an immune adjuvant.

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Section: Discussionmentioning

confidence: 99%

Immune adjuvant effect of Juzentaihoto, a Japanese traditional herbal medicine, on tumor vaccine therapy in a mouse model

Takeno

Inujima

Shinohara

et al. 2015

International Journal of Oncology

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“…Among these constituents, Rehmannia root, achyranthes root, Dioscorea rhizome and moutan bark have been shown to improve blood circulation . Moreover, Yamakawa et al investigated the chemical profile of USH (goshajinkigan; TJ‐107) using 3‐D high‐performance liquid chromatography , the constituents of which, including (+)‐catechin, morroniside, paeoniflorin, cinnamaldehyde and cinnamic acid, have been shown to improve blood circulation . Taken together, these herbs and chemical constituents may contribute to the inhibitory effect of USH on cold‐mediated responses in HDMEC.…”

Section: Discussionmentioning

confidence: 99%

“…USH was manufactured and purchased from Tsumura (ID code: TJ‐107; Tokyo, Japan). According to the manufacturer's description, Tsumura USH consists of mixed dried extract and inactive ingredients including 3 g Rehmannia root, 3 g achyranthes root, 3 g Cornus fruit, 3 g Dioscorea rhizome, 3 g Plantago seed, 3 g Alisma rhizome, 3 g Poria sclerotium, 1 g moutan bark, 1 g cinnamon bark, and 5 g powdered processed aconite root . They are standardized spray‐dried water extract.…”

Section: Methodsmentioning

confidence: 99%

Inhibitory effect of ucha‐shinki‐hwan on cold‐mediated response in human dermal microvascular endothelial cells

Lee

Cho

Lee

et al. 2017

Traditional & Kampo Medicine

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Aim Raynaud's phenomenon is characterized by prolonged vasoconstriction in cutaneous capillaries on cold stress. RhoA activity would be a therapeutic target for treating Raynaud's phenomenon. A traditional herbal medicine, ucha‐shinki‐hwan, has been used to promote vasodilation, but the biological mechanism of ucha‐shinki‐hwan is still unclear. Thus, we hypothesized that ucha‐shinki‐hwan is able to be used for treatment of Raynaud's phenomenon and that ucha‐shinki‐hwan inhibits cold‐induced vasoconstriction by targeting RhoA GTPase. Methods Human dermal microvascular endothelial cells were pretreated with ucha‐shinki‐hwan for 30 min, followed by incubation in room temperature (37 ± 2°C) or a lower temperature (25 ± 2°C) for 30 min. Expression of active RhoA was measured on western blot. Endothelin‐1 and nitric oxide production were examined on enzyme‐linked immunosorbent assay. The formation of stress fiber and focal adhesion complex was analyzed using immunocytochemistry. Results Cold exposure activated RhoA GTPase whereas ucha‐shinki‐hwan treatment suppressed its activation in human dermal microvascular endothelial cells. Moreover, ucha‐shinki‐hwan decreased cold‐induced endothelin‐1 and nitric oxide production. In addition, ucha‐shinki‐hwan treatment inhibited the formation of stress fiber and focal adhesion complex with downregulation of focal adhesion kinase (FAK), SRC kinase and extracellular regulated kinases (ERK) phosphorylation. Conclusion Ucha‐shinki‐hwan inhibits contraction of cold‐exposed human dermal microvascular endothelial cells by targeting RhoA activation. This in vitro study is therefore the first to suggest that ucha‐shinki‐hwan is likely to be effective for inhibiting cold‐induced response in vascular endothelial cells.

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“…Its main components are coptisine, baicalin, palmatine, berberine, and wogonoside and are known to react amongst them in the preparation [59]. A formulation (hangeshashinto) known for hangover relief contains Pinellia tuber, Scutellaria root, processed ginger, Glycyrrhiza, Jujube, Ginseng, and Coptis rhizome, whose active compounds in this formulation are glycyrrhizin, liquiritin, baicalin, berberine, and glucuronides [60].…”

Section: Plant Extracts and Plant Concoctionsmentioning

confidence: 99%

Preventing and Mitigating Alcohol Toxicity: A Review on Protective Substances

2018

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This review covers three fundamental aspects of alcohol consumption and research efforts around the prevention and mitigation of its toxic effects in the human body. First, the sociocultural aspects of alcohol consumption are analysed, including drinking habits and strategies to combat intoxication. Second, we briefly introduce the biochemical aspects of ethanol metabolism and the biochemical pathways leading to its degradation, particularly the activation of toxic response pathways. Finally, we review current evidence and research efforts for finding compounds and substances able to prevent and mitigate the toxic effects of alcohol when over-indulgence has occurred. The toxic effects appear as a time-evolution process based on the stage of intoxication. We explore different compounds and formulations traditionally used to combat alcohol toxicity, as well as state-of-the-art research in the topic for novel molecules and formulations. Although we aimed to categorise which compounds are more effective for a particular level of alcohol intoxication, it is impossible to fully prevent or mitigate toxicity effects by only the compounds in isolation, further research is required to establish the long-term prevention and mitigation from the clinical point of view.

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Significance of Kampo, Traditional Japanese Medicine, in Supportive Care of Cancer Patients

Cited by 17 publications

References 85 publications

Immune adjuvant effect of Juzentaihoto, a Japanese traditional herbal medicine, on tumor vaccine therapy in a mouse model

Immune adjuvant effect of Juzentaihoto, a Japanese traditional herbal medicine, on tumor vaccine therapy in a mouse model

Inhibitory effect of ucha‐shinki‐hwan on cold‐mediated response in human dermal microvascular endothelial cells

Preventing and Mitigating Alcohol Toxicity: A Review on Protective Substances

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