Lately, a new class of nanofluids, namely hybrid nanofluids, has been introduced that performs much better compared with the nanofluids when a healthier heat transfer rate is the objective of the study. Heading in the same direction, the present investigation accentuates the unsteady hybrid nanofluid flow involving CuO, Al2O3/C2H6O2 achieved by an oscillating disk immersed in the porous media. In a study of the homogeneous and heterogeneous reactions, the surface catalyzed reaction was also considered to minimize the reaction time. The shape factors of the nanoparticles were also taken into account, as these play a vital role in assessing the thermal conductivity and heat transfer rate of the system. The assumed model is presented mathematically in the form of partial differential equations. The system is transformed by invoking special similarity transformations. The Keller Box scheme was used to obtain numerical and graphical results. It is inferred that the blade-shaped nanoparticles have the best thermal conductivity that boosts the heat transfer efficiency. The oscillation and surface-catalyzed chemical reactions have opposite impacts on the concentration profile. This analysis also includes a comparison of the proposed model with a published result in a limiting case to check the authenticity of the presented model.