Significance of Meconium-Stained Amniotic Fluid in the Preterm Population

Scott, Heather; Walker, Mark; Gruslin, Andrée

doi:10.1038/sj.jp.7200521

Cited by 32 publications

(13 citation statements)

References 11 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…11 In a study done by Scott H et al on the significance of meconium stained amniotic fluid on preterm population it was seen that the incidence of MSAF in preterm deliveries is relatively low and there was no evidence that the presence of meconium is a marker for acute hypoxia. 12 Similarly on our study, MSAF babies had acidemia but not all indicating that there are other causes for meconium stained amniotic fluid and not just intra uterine hypoxia.…”

Section: Discussionsupporting

confidence: 69%

Correlation between umbilical cord blood pH and meconium stained deliveries

Lysander

Chandrakala

Jayalalitha

2020

Int J Contemp Pediatr

View full text Add to dashboard Cite

Background: Among all live births approximately 13% neonates are born through meconium-stained amniotic fluid and out of these 5-10% developed MAS, which increases neonatal morbidity and mortality. The incidence increases as the gestational age advances with reported frequencies at 37, 40, and >42 weeks being 3%, 13%, and 18% respectively. Although there is a significant decrease in the occurrence of MAS and associated mortality in developed countries, MAS remains a major problem in developing countries. The objective was to study the correlation between umbilical cord blood PH and Meconium stained amniotic fluid.Methods: Observational study done in KIMS hospital Bangalore, Karnataka, India in a study period of 18 months on a sample size of 100. Within 30 sec of delivery a segment of umbilical cord was clamped at both ends. Cord blood was collected in heparinised syringe. It was then transported with cold ice packs and blood pH, pCO2, pO2 were measured.Results: In present study population, among those with MSAF, 72% had acidemia and 28% did not have acidemia. The mean (SD) of pH in the group with MSAF was 7.16 (0.10). The median (IQR) of pH in the group with MSAF was 7.14 (0.12). There was no significant difference between the groups (those with MSAF and those without MSAF but other risk factors) in terms of pH (W = 867.500, p = 0.580).Conclusions: The presence of acidosis in the umbilical cord blood, used as a biochemical marker for perinatal asphyxia can be used to evaluate the significance of intrauterine passage of meconium. But a normal acid-base status at delivery present in many cases of MSAF, suggests that either a pre-existing injury or a non-hypoxic mechanism is often involved. MSAF is not always secondary to an acute hypoxic event.

show abstract

Section: Discussionsupporting

confidence: 69%

Correlation between umbilical cord blood pH and meconium stained deliveries

Lysander

Chandrakala

Jayalalitha

2020

Int J Contemp Pediatr

View full text Add to dashboard Cite

show abstract

“…The passage of meconium in newborns is an incident planned for development usually in the first 24 to 48 h after birth [6]. However, during pregnancy, the fetus can transfer meconium through the amniotic fluid for various reasons [7]. MSAF is rare before 37 weeks of gestation and increases with increasing gestational age [8].…”

Section: Introductionmentioning

confidence: 99%

Association of Apgar Score With Meconium Staining of Amniotic Fluid in Labor

Masood¹,

Shahid²,

Bano

et al. 2021

Cureus

View full text Add to dashboard Cite

This study aimed to determine the association of Apgar score with meconium staining of amniotic fluid in labor. MethodologyA retrospective observational study was carried out through the non-probability convenient sampling technique at the Department of Obstetrics and Gynecology for a duration of six months. Only those women were selected who had more than 24 weeks of gestation period. The women were excluded on the basis of risk factors for fetal distress and breech in late labor. ResultsA total of 216 pregnant women were selected from the labor room in this study. The mean age of the women was 26.57±4.28 years. The gestational age of the women was 36.09±4.11 weeks. Moreover, the mean parity of pregnant women was 1.68±2.53. It has been observed that the women who had meconium staining, the neonates of 144(77.4%) women showed the Apgar score of less than six at one minute. However, for the women without meconium staining, the neonates of only 15(50%) women showed the Apgar score of less than six at the one-minute interval with a significant association (p=0.02). With respect to age groups, a significant association of meconium staining with Apgar score was noted in the 21-30 years age group, whereas, no significant association was seen in other age groups. Similarly, a significant association of meconium staining and Apgar score was noted in primiparous women, whereas, no significant association was noted in multiparous women. No significant association of Apgar score and meconium staining was seen with respect to the mode of delivery. ConclusionThe study has found a relation between the Apgar score and meconium staining of amniotic fluid and reported that the Apgar score of less than six at one minute was significantly associated with meconium staining of amniotic fluid.

show abstract

“…Meconium is sterile, unlike faeces, and is odourless. Fetal defecation is a normal physiological process; to date, however, there is some evidence that in the third gestation trimester, there has been an increase in the number of children with MSAF requiring intensive care unit treatment [1,2].…”

Section: Introductionmentioning

confidence: 99%