2016
DOI: 10.1016/j.ecoenv.2016.01.015
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Significance of metabolite extraction method for evaluating sulfamethazine toxicity in adult zebrafish using metabolomics

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Cited by 19 publications
(9 citation statements)
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“…However, more important changes were observed on the biliary pathways (Figure 4). Similar effects were observed on zebrafish metabolomic model from sulfonamides contaminated water [9].…”
Section: Resultssupporting
confidence: 77%
See 1 more Smart Citation
“…However, more important changes were observed on the biliary pathways (Figure 4). Similar effects were observed on zebrafish metabolomic model from sulfonamides contaminated water [9].…”
Section: Resultssupporting
confidence: 77%
“…Sulfonamides compete with bilirubin for its binding sites and therefore should not be administered during the last trimester of pregnancy and to new-borns. Unconjugated bilirubin may be deposited in the basal ganglia of the brain and in the subthalamus, leading to toxic encephalopathy [9,20,32]. The toxic effect in humans is explained through the metabolism mechanism of those substances.…”
Section: Introductionmentioning
confidence: 99%
“…Thus, using OPLS-DA, the top 5% discriminatory metabolites were considered for discriminating important features between thrombotic stroke vs. control. 39…”
Section: Separation Of Control and Thrombotic Stroke Risk Patients Bymentioning
confidence: 99%
“…The injection volume was 5 µl, with a flow rate of 0.4 ml/min and a column temperature of 40°C. Masses of metabolites ranging from 50–1000 m/z were detected using the Agilent 6530 Accurate Mass Q-TOF-LC/MS (Agilent Technologies, Inc.) in the positive ionization mode ( 25 ). This LC-MS/MS is ideally suited for metabolic stability and profiling studies, as this system is highly sensitive for the detection of compounds at low concentrations (pg/ml), has a resolving power of 40 k, and is able to identify masses and isotopes for the accurate identification of metabolites.…”
Section: Methodsmentioning
confidence: 99%