Significance of metallothioneins in metal accumulation kinetics in marine animals

Wang, Wen‐Xiong; Rainbow, Philip S.

doi:10.1016/j.cbpc.2010.02.015

Cited by 44 publications

(38 citation statements)

References 51 publications

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“…However, our present understanding of the other biological functions of MTLPs in addition to detoxification is limited [15]. Recently, the elevation of metal uptake through metal pre-exposure has been suggested to be attributable to MTLP induction [5,15], a finding based on a significant correlation between body MTLP concentrations and metal uptake in several aquatic organisms [6,8,16]. One hypothesis is that the induced MTLPs can reduce intracellular labile metal concentration, leading to a higher gradient of the metal across cell membrane, subsequently enhancing the metal uptake rate [5].…”

Section: Introductionmentioning

confidence: 93%

“…Cadmium is well recognized as one of the MTLP inducers [9,10,14]. However, our present understanding of the other biological functions of MTLPs in addition to detoxification is limited [15]. Recently, the elevation of metal uptake through metal pre-exposure has been suggested to be attributable to MTLP induction [5,15], a finding based on a significant correlation between body MTLP concentrations and metal uptake in several aquatic organisms [6,8,16].…”

Section: Introductionmentioning

confidence: 98%

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Differential roles of metallothionein-like proteins in cadmium uptake and elimination by the scallop Chlamys nobilis

Liu

Wang

2011

Environmental Toxicology and Chemistry

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Metallothionein-like proteins (MTLPs) are important inducible ligands for Cd detoxification, but whether MTLPs are involved in Cd bioaccumulation remains unclear. The present study investigated the potential interrelationships between MTLP turnover and Cd biokinetics in the scallop Chlamys nobilis with or without dissolved Cd pre-exposure. After Cd pre-exposure, increased synthesis rate and standing stock concentration of MTLPs as well as increased dissolved Cd uptake rate, were found in C. nobilis. However, the level of newly sequestrated Cd by MTLPs in the pre-exposed scallops was similar to that of the controls, indicating that MTLPs had no effect on Cd uptake from the dissolved phase. Instead, Cd uptake rate was positively related to the Cd binding rate of cellular debris and organelles. In addition, no significant difference was observed in the Cd dietary assimilation efficiency of the scallops, showing that MTLPs played a minimal role in Cd uptake from the dietary phase. Conversely, the Cd efflux rate constant decreased by 68 to 75% in the pre-exposed scallops in comparison with that in the control. Correspondingly, progressive elevations of MTLP-bound Cd and standing stock MTLP concentration were observed in the pre-exposed individuals during the Cd elimination period. In the pre-exposed scallops, the faster de novo MTLP synthesis could remobilize and recycle more Cd from other intracellular pools, effectively reducing the Cd elimination rate. The present study thus showed the differential roles of MTLPs in Cd uptake and elimination in the bivalves.

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Section: Introductionmentioning

confidence: 93%

Section: Introductionmentioning

confidence: 98%

Differential roles of metallothionein-like proteins in cadmium uptake and elimination by the scallop Chlamys nobilis

Liu

Wang

2011

Environmental Toxicology and Chemistry

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“…1). Uptake from water and food (trophic transfer) are several sources contributing to metal accumulation in marine animals (Wang and Rainbow, 2010). High Cd concentrations have been reported previously in livers and kidneys of marine mammals suggesting that oceanic cephalopods constituted a significant part of their diet (Bustamante et al, 1998;Das et al, 2000) or that marine mammals were ingesting prey from polluted areas (Wagemann and Muir, 1984).…”

Section: Non Essential Elementsmentioning

confidence: 99%

“…Moreover metallothioneins are able to bind non-essential metals such as Cd and Hg (Reviewed by Das et al (2003)). Therefore, the functions of metallothioneins are considered to be metal storage / detoxification of non-essential metals (Cd and Hg) or homoeostatic regulation of essential metals (Zn and Cu) (Reviewed by Wang and Rainbow (2010)). This correlation between toxic Cd and essential Cu and Zn would suggest induction of metallothioneins and possible competition or increase in metal binding sites (Wagemann et al, 1988).…”

Section: Essential Elementsmentioning

confidence: 99%

Harbour porpoises (Phocoena phocoena) stranded along the southern North Sea: An assessment through metallic contamination

Mahfouz

Henry

Courcot

et al. 2014

Environmental Research

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a b s t r a c tThroughout the last few years, the southern North Sea has witnessed an increase in the number of stranded marine mammals, particularly the harbour porpoise (Phocoena phocoena). This species is subject to several potential threats such as exposure to contaminants, changes in food supply, marine traffic and fishery by-catch. The aims of this study were to investigate potential associations between contaminants and health status and to analyze spatial and temporal trends of metal concentrations in harbour porpoises. Selected trace elements (As, Cd, Cr, Cu, Hg, Mn, Se, V and Zn) were measured in kidneys and livers of 105 harbour porpoises stranded along the southern North Sea (French and Belgian coasts from 2006 to 2013) and 27 stranded along the Bay of Biscay (French coast from 2009 to 2012). Porpoises that died from infectious disease displayed significant higher hepatic concentrations of Cd, Hg, Se and Zn compared to healthy porpoises that died from physical trauma. Adult porpoises displayed significant higher concentrations of Cd, Cr, Hg, Se and V in livers compared to juveniles. No spatial or temporal trends in metal concentrations were detected in our study. The results of the present study suggested that chemical contamination may represent one of many threats encountered by harbour porpoises, but it cannot explain alone the increase in the number of stranded individuals.

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“…Most biotic factors that influence metal bioaccumulation are associated with diet and include metal concentrations in prey species and feeding rate. Therefore, future studies analyzing Cd and Zn in the most important food sources, as well as their uptake rates, assimilation efficiencies, and detoxification mechanisms by crabs, could yield more insights into the contribution of each pathway [36,37].…”

Section: Discussionmentioning

confidence: 99%

Environmental concentrations and bioaccumulations of cadmium and zinc in coastal watersheds along the Chinese Northern Bohai and Yellow Seas

Luo

Lü

Wang

et al. 2013

Environmental Toxicology and Chemistry

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Abstract-Cadmium (Cd) and zinc (Zn) in surface water, sediment, carp, and crab samples collected from upstream and downstream regions of coastal watersheds along the Chinese Northern Bohai and Yellow Seas were analyzed to provide a comprehensive understanding and assessment of their environmental concentrations and bioaccumulations. The results showed that downstream waters contaminated with Zn would have adverse effects on aquatic organisms. Although nearly all sediments were contaminated with Cd due to human activities, little potential existed for Cd toxicity in sediment-dwelling fauna. Concentrations of Cd and Zn in most water, sediment, carp, and crab were less than published values. The downstream carp and crabs had higher mean bioaccumulation factors and biotasediment accumulation factors for Cd but lower mean biota-sediment accumulation factors for Zn than the upstream carp and crabs. Based on the relationships among Cd and Zn concentrations in water, sediment, and biota, the authors conclude that Cd and Zn in crabs primarily derived from sediment exposure. Although Cd and Zn in water and sediment originated from some of the same sources, the sources of Cd or Zn in water were likely different from those in sediment. Environ. Toxicol. Chem. 2013;32:831-840. # 2013 SETAC

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Significance of metallothioneins in metal accumulation kinetics in marine animals

Cited by 44 publications

References 51 publications

Differential roles of metallothionein-like proteins in cadmium uptake and elimination by the scallop Chlamys nobilis

Differential roles of metallothionein-like proteins in cadmium uptake and elimination by the scallop Chlamys nobilis

Harbour porpoises (Phocoena phocoena) stranded along the southern North Sea: An assessment through metallic contamination

Environmental concentrations and bioaccumulations of cadmium and zinc in coastal watersheds along the Chinese Northern Bohai and Yellow Seas

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