Significance of molecular markers in survival prediction of oral squamous cell carcinoma

Kim, Ki Yeol; Li, Sheng Jin; Dan, Jeong; Zhang, Xianglan; Ho, In

doi:10.1002/hed.21856

Cited by 39 publications

(46 citation statements)

References 61 publications

(48 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Four studies reported no site-specific HNC [24, 54–57] and others recorded site-specific HNC. There were 7, 6 and 9 studies focused on oral cancer (OC) [22, 25, 27, 37–40], laryngeal cancer (LC) [41–46] and nasopharyngeal cancer (NPC) [23, 26, 47–53], respectively. The total number of patients was 2430, ranging from 20 to 301 cases per study.…”

Section: Resultsmentioning

confidence: 99%

See 1 more Smart Citation

Clinicopathological and prognostic significance of cyclooxygenase-2 expression in head and neck cancer: A meta-analysis

et al. 2016

View full text Add to dashboard Cite

Several studies have assessed the clinicopathological and prognostic value of cyclooxygenase-2 (COX-2) expression in patients with head and neck cancer (HNC), but their results remain controversial. To address this issue, a meta-analysis was carried out. A total of 29 studies involving 2430 patients were subjected to final analysis. Our results indicated that COX-2 expression was not statistically associated with advanced tumor stage (OR, 1.23; 95% CI, 0.98–1.55) but correlated with high risk of lymph node metastasis (OR, 1.28; 95% CI, 1.03–1.60) and advanced TNM stage (OR, 1.33; 95% CI, 1.06–1.66). Moreover, COX-2 expression had significant effect on poor OS (HR, 1.93; 95% CI, 1.29–2.90), RFS (HR, 2.02; 95% CI, 1.00–4.08) and DFS (HR, 5.14; 95% CI, 2.84–9.31). The results of subgroup analyses revealed that COX-2 expression was related with high possibility of lymph node metastasis in oral cancer (OR, 1.49; 95% CI, 1.01–2.20) and advanced TNM stage in oral cancer (OR, 1.58; 95% CI, 1.05–2.37) and no site-specific HNC (OR, 1.64; 95% CI, 1.02–2.62). However, subgroup analyses only showed a tendency without statistically significant association between COX-2 expression and survival. Significant heterogeneity was not found when analyzing clinicopathological data, but it appeared when considering survival data. No publication bias was detected in this study. This meta-analysis suggested that COX-2 expression could act as a prognostic factor for patients with HNC.

show abstract

Section: Resultsmentioning

confidence: 99%

“…Second, the existing studies are conflicting in their results. Some studies suggested that COX-2 expression was associated with poor prognosis in HNC [22–24], whereas other studies failed to demonstrate such correlation [25–27]. Therefore, it is still difficult to determine the prognostic value of COX-2 expression.…”

Section: Introductionmentioning

confidence: 99%

Clinicopathological and prognostic significance of cyclooxygenase-2 expression in head and neck cancer: A meta-analysis

et al. 2016

View full text Add to dashboard Cite

show abstract

“…Although extensively studied in several cancer types, only a few studies have previously investigated the expression status of IMP3 in HNSCC. IMP3 overexpression in SCC of the oral cavity was shown to be an independent predictive marker for an advanced clinical stage, lymph node metastasis and as a prognostic indicator (29)(30)(31). Furthermore, it has been reported to be an indicator of a poor prognosis and a marker of enhanced malignancy in SCC of the tongue and larynx (32)(33)(34)(35).…”

Section: Discussionmentioning

confidence: 96%

“…However, only a few studies have previously investigated the expression of IMP3 in head and neck SCC from specific sites (29)(30)(31)(32)(33)(34). In particular, the pattern of IMP3 expression in HNSCC with regards to the HPV status has not previously been investigated.…”

Section: Introductionmentioning

confidence: 99%

IMP3 and p16 expression in squamous cell carcinoma of the head and neck: A comparative immunohistochemical analysis

et al. 2017

View full text Add to dashboard Cite

Abstract. Expression of p16 has been established as a good surrogate marker for high-risk human papillomavirus (HPV) infection in oropharyngeal squamous cell carcinoma (OPSCC) patients, and it has been associated with an improved prognosis, irrespective of the actual HPV status. Conversely, the human insulin-like growth factor II mRNA binding protein 3 (IMP3) has been related to aggressiveness in several types of tumors. The aim of the present study was to investigate and compare p16 and IMP3 as markers of favorable and unfavorable behavior, respectively, in head and neck SCC (HNSCC), with particular reference to the HPV status. Both markers were analyzed by immunohistochemical analysis of 156 HNSCC samples originating from the oropharynx (n=81), oral cavity (n=44), larynx (n=15), hypopharynx (n=10) and nasopharynx (n=6). The HPV status was examined in a randomly selected representative subcohort (n=38) using polymerase chain reaction. Of the 156 HNSCC samples, 81 (51.9%) and 54 (34.6%) were positive for IMP3 and p16, respectively. IMP3 expression (P=0.022), p16 expression (P<0.001) and the combination of these markers (P<0.001) were significantly associated with tumor site. In particular, 69/81 (85%) OPSCC samples were positive for either one or both markers compared with 36/75 (48%) SCC samples from other sites. p16 expression was significantly associated with HPV infection (P= 0.017) and a trend towards a negative association between IMP3 expression and HPV infection was observed (P=0.053). The results of the present study suggested that IMP3 and p16 are more frequently expressed in OPSCC compared with other HNSCCs. The prognostic impact of IMP3 on OPSCC remains to be investigated in a larger series with an extended follow-up period. IntroductionSquamous cell carcinoma (SCC) is the leading cancer type affecting the head and neck region (HNSCC) representing >90% of malignant neoplasms of the oral cavity and oropharynx and 5 and 2% of all cancers in men and women, respectively (1). Tobacco smoking and alcohol consumption are the two major etiological factors of HNSCC and they work in a synergistic manner to initiate SCC (1). Approximately 75% of HNSCC cases in western countries are related to these two major risk factors, while the remainder is predominantly associated with viral infection, in particular infection with high-risk human papillomavirus (HPV) (1). HPV has been detected in a small fraction of oral cavity SCCs, and in 40-50% of oropharyngeal (mainly tonsillar) SCC (OPSCC) (1). While HPV-associated HNSCC may occur at any site, including the sinonasal tract, the majority of HPV-related SCCs originate in the lymphoid tissue bearing the oropharynx, mainly the palatine tonsil and the base of the tongue (1). Expression of p16 as a consequence of oncogenic HPV infection has been increasingly used as a surrogate marker for high-risk HPV infection, particularly in the female genital tract and the oropharynx (2,3). The sensitivity and specificity of p16 immunostaining for detecting high-risk HPV in OPSCC patie...

show abstract

“…Only 3 years later, Lothaire postulated that some putative prognostic biomarkers may have more impact for prognostic analyses in OSCC than TNM and grading alone [5]. Some of the reviews give an excessive overview about different prognostic proteins in the carcinogenesis of OSCC [6]. The progression of oral squamous cell carcinoma is a complex multistep process and not completely understood.…”

Section: Introductionmentioning

confidence: 98%

Correlation of expression of hypoxia-related proteins with prognosis in oral squamous cell carcinoma patients

Eckert

Kappler

Schubert

et al. 2012

Oral Maxillofac Surg

View full text Add to dashboard Cite

show abstract

Significance of molecular markers in survival prediction of oral squamous cell carcinoma

Abstract: Survival in OSCC can be predicted more accurately by using biomarkers. The constructed nomogram predicted survival after treatment for an individual patient with OSCC, and it can be practically used as a tool to help decide which adjuvant treatment is most appropriate.

Cited by 39 publications

References 61 publications

Clinicopathological and prognostic significance of cyclooxygenase-2 expression in head and neck cancer: A meta-analysis

Clinicopathological and prognostic significance of cyclooxygenase-2 expression in head and neck cancer: A meta-analysis

IMP3 and p16 expression in squamous cell carcinoma of the head and neck: A comparative immunohistochemical analysis

Correlation of expression of hypoxia-related proteins with prognosis in oral squamous cell carcinoma patients

Contact Info

Product

Resources

About