Significance of MSH2 promoter methylation in endometrial cancer with MSH2 deficiency

Haraga, Jessica; Nagasaka, Takeshi; Nakamura, Kenichi; Haruma, Tomonori; Nishida, Tatsuya; Nyuya, Akihiro; Yasui, Kohichiroh; Fujiwara, Tomohiro; Goel, Ajay; Masuyama, Hisashi

doi:10.1093/annonc/mdx372.049

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“…The present study found a similar percentage of MLH1 positivity compared with previous studies [21] , [22] . However, MSH2 negativity was higher in the present study compared with some previous studies [21] , [24] , but lower compared with another study [25] . For p53, the present study found a mutant pattern of expression in approximately 14% of cases, despite the fact that approximately 25% of the series were non-ECs.…”

Section: Discussioncontrasting

confidence: 89%