Significance of neutrophil-to-lymphocyte ratio, platelet-to-lymphocyte ratio for predicting clinical outcomes in COVID-19

Zhang, Ting; Huang, Shaoping; M, Liu; Li, Xiaolu; Shang, Zhiyin; Lu, Hongzhou

doi:10.21203/rs.3.rs-34983/v1

Cited by 3 publications

(3 citation statements)

References 21 publications

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“…As shown in Table 1, most of studies were from China, and six studies were published from other countries [11,12,25,28,40,43]. Among of them, 41 studies with 10,335 patients were analyzed for the association of renal impairment with severity of COVID-19 [2][3][4]9,[11][12][13][14][16][17][18]20,21,23,[26][27][28][29][30][31][32][33][34][36][37][38][39][41][42][43][44][45][46][47][49][50][51][54][55][56][57]. In additions, 11 studies with 3759 patients reported the association of renal impairment with mortality of COVID-19 [1,…”

Section: Study Characteristicsmentioning

confidence: 99%

Association of acute kidney injury with the severity and mortality of SARS-CoV-2 infection: A meta-analysis

Ouyang

Gong

Zhu

et al. 2021

The American Journal of Emergency Medicine

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Background we aimed to explore the relationship of acute kidney injury (AKI) with the severity and mortality of coronavirus disease 2019 (COVID-19). Methods A systematic literature search was conducted in PubMed, EMBASE, Scopus, Web of Science, MedRxiv Database. We compared the laboratory indicators of renal impairment and incidences of AKI in the severe versus non-severe cases, and survival versus non-survival cases, respectively. Results In 41 studies with 10,335 COVID-19 patients, the serum creatinine (sCr) in severe cases was much higher than that in non-severe cases (SMD = 0.34, 95% CI: 0.29–0.39), with a similar trend for blood urea nitrogen (BUN) (SMD = 0.66, 95%CI: 0.51–0.81), hematuria (OR = 1.59, 95% CI: 1.15–2.19), and proteinuria (OR = 2.92, 95% CI: 1.58–5.38). The estimated glomerular filtration rate decreased significantly in severe cases compared with non-severe cases (SMD = -0.45, 95% CI: −0.67–0.23). Moreover, the pooled OR of continuous renal replacement therapy (CRRT) and AKI prevalence for severe vs. non-severe cases was 12.99 (95%CI: 4.03–41.89) and 13.16 (95%CI: 10.16–17.05), respectively. Additionally, 11 studies with 3759 COVID-19 patients were included for analysis of disease mortality. The results showed the levels of sCr and BUN in non-survival cases remarkably elevated compared with survival patients, respectively (SMD = 0.97, SMD = 1.49). The pooled OR of CRRT and AKI prevalence for non-survival vs. survival cases was 31.51 (95%CI: 6.55–151.59) and 77.48 (95%CI: 24.52–244.85), respectively. Conclusions AKI is closely related with severity and mortality of COVID-19, which gives awareness for doctors to pay more attention for risk screening, early identification and timely treatment of AKI.

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Section: Study Characteristicsmentioning

confidence: 99%

Association of acute kidney injury with the severity and mortality of SARS-CoV-2 infection: A meta-analysis

Ouyang

Gong

Zhu

et al. 2021

The American Journal of Emergency Medicine

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“…These results are supported by a study by 24 , in which there are significant differences in PLR in severe and non-severe COVID -19. Research by Zhang et al (2020) 34 also showed that there was a significant difference in PLR value for the severity of COVID -19. As an indicator of inflammation, PLR is primarily caused by megakaryocytes in the bone marrow recruiting neutrophils and other inflammatory cells to the site of injury.…”

Section: Resultsmentioning

confidence: 94%

Comparison of Platelet-to-Lymphocyte Ratio at Different COVID-19 Severity in Adam Malik Hospital, Medan, Indonesia

Nurul Mandasari,

Gatot,

Syahrini Lubis

2023

Int J Res Rev

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Introduction. Several inflammatory indicators such as neutrophil-to-lymphocyte ratio (NLR), platelet-to-lymphocyte ratio (PLR), and lymphopenia have shown an inflammatory response of COVID-19. Nevertheless, not much research has been done in Indonesia. This study aims to determine the difference between PLR and severity of COVID-19 disease in Adam Malik Hospital, Medan. Method. A retrospective study was conducted from September 2020 to February 2021 to analyze the medical records of patients with confirmed COVID-19. Patients' clinical severity was categorized according to the criteria of WHO. PLR is calculated by dividing the platelet count by the lymphocyte count obtained from a complete blood count of a COVID-19 patient at the time of hospital admission. A comparative analysis was performed to determine differences in PLR at different clinical severities of COVID-19. Results. A total of 114 patients were enrolled in the study. Most of the COVID-19 patients are patients with non-severe grade, 57.1%, while the other 42.9% are patients with severe grade. In both severity grades, the platelet count is basically normal, while a low lymphocyte count is observed in the severe severity grades. Higher PLR values were found in severe COVID -19 patients, with a significant difference between severe and non-severe patients (p=0.00). Conclusion. There is a significant difference in PLR in severe and non-severe COVID -19 grades. Keywords: Platelet-to-lymphocyte Ratio, Severity, COVID-19, Inflammation

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“…The study from Yabing Guo and Wenhua Liang reported 2 sets of data. Therefore, 19 datasets were included in the quantitative synthesis (18 datasets from 16 studies combined with our case-control study) [6,[20][21][22][23][24][25][26][27][28][29][30][31][32][33][34].…”

Section: Meta-analysesmentioning

confidence: 99%

The neutrophil to lymphocyte ratio is an independent predictor for severe COVID-19

Cheng

Yang

et al. 2021

Wien Klin Wochenschr

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Summary Purpose The aim of this study was to determine whether the neutrophil to lymphocyte ratio (NLR) can predict severe Coronavirus disease 2019 (COVID-19). Patients and methods A multicenter case-control study was conducted to investigate whether the NLR can help predict the severity of COVID-19. Patients confirmed to have COVID-19 between 16 January 2020 and 15 March 2020 were enrolled. Furthermore, meta-analyses were conducted based on both previous studies and our case-control study. Results In the case-control study, 213 patients (severe: 81) were included. The results suggested that the NLR was an independent risk factor (odds ratio [OR], 1.155, 95% confidence interval [95% CI]: 1.043–1.279, P = 0.006) and a great predictor (the area under the ROC curve was 0.728, 95% CI: 0.656–0.800) for severe COVID-19. In total, 18 datasets from 16 studies combined with our case-control study (severe: 1211; non-severe: 5838) were included in the meta-analyses and the results showed that the NLR of the severe COVID-19 group was significantly higher than that of the non-severe group (SMD = 1.10, 95% CI: 0.90–1.31, P < 0.001). Based on the 2 × 2 data from 6 studies, the SROC of NLR for predicting severe COVID-19 was 0.802, with a sensitivity of 0.67 (95% CI: 0.61–0.72) and a specificity of 0.75 (95% CI: 0.73–0.78). Conclusion Based on a multicenter case-control study and a meta-analysis, we found that the initial NLR was a great predictor of severe COVID-19.

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Significance of neutrophil-to-lymphocyte ratio, platelet-to-lymphocyte ratio for predicting clinical outcomes in COVID-19

Cited by 3 publications

References 21 publications

Association of acute kidney injury with the severity and mortality of SARS-CoV-2 infection: A meta-analysis

Association of acute kidney injury with the severity and mortality of SARS-CoV-2 infection: A meta-analysis

Comparison of Platelet-to-Lymphocyte Ratio at Different COVID-19 Severity in Adam Malik Hospital, Medan, Indonesia

The neutrophil to lymphocyte ratio is an independent predictor for severe COVID-19

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