Significance of obesity markers and adipocytokines in high grade and high stage prostate cancer in North Indian men – A cross-sectional study

Tewari, Reshu; Rajender, Singh; Natu, S.M.; Goel, Apul; Dalela, Divakar; Goel, Madhumati; Tondon, Pushpa

doi:10.1016/j.cyto.2013.04.008

Cited by 25 publications

(31 citation statements)

References 32 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…The details of patient recruitment and clinical parameters are given in our earlier study (Tewari et al, 2013). Apart from the clinical measures presented in the above-mentioned study, we undertook assays to measure the levels of insulin, testosterone, dihydrotestosterone, and detailed lipid profile.…”

Section: Methodsmentioning

confidence: 99%

“…comparison to BPH and so in high grade prostate cancer in comparison to low grade cancer (Tewari et al, 2013). Obesity suggests higher stores of adipose tissue as a source of cholesterol and triglycerides (Tewari et al, 2011); therefore, a disturbed lipid profile may be seen in the patients of prostate cancer and BPH.…”

Section: Introductionmentioning

confidence: 99%

“…Further, many studies have shown an association of dyslipedimia in BPH (Nandeesha et al, 2006) and prostate cancer (Gillitizer et al, 2005;Clarke and Brown, 2007). Distrubed level of adipocytokines has been correlated with PCa risk and its higher grade by us (Tewari et al 2013) and others (Zhang et al, 2014). It has been established that Dihydrotestosterone is the principal androgen responsible for both normal and hyperplastic growth of the prostate gland.…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Significant Association of Metabolic Indices, Lipid Profile, and Androgen Levels with Prostate Cancer

Tewari

Chhabra²,

Natu³

et al. 2014

Asian Pacific Journal of Cancer Prevention

Self Cite

View full text Add to dashboard Cite

Objectives: To compare the metabolic indices, lipid profile, androgens, and prostate specific antigen between prostate cancer and BPH and between grades of prostate cancer in a cross-sectional study. Materials and Methods: The study enrolled 95 cases of prostate cancer and 95 cases of benign prostatic hyperplasia (BPH). Prostate gland volume was measured using transrectal ultrasound. We compared insulin, testosterone, dihydrotestosterone, prostate specific antigen levels and lipid profile between prostate cancer of different grades and BPH. Further, prostate cancer patients were classified into low grade and high grade. Unpaired t-test for normally distributed variables and Man-Whitney U test for non-normal variables were used to assess differences. Results: We found that prostate cancer patients had significantly higher levels of insulin, testosterone, PSA, cholesterol, triglycerides, low-density lipoprotein (LDL) and very low-density lipoprotein (VLDL) in comparison to their BPH counterparts. Higher levels of these parameters also correlated with a higher grade of the disease. Conclusions: We conclude that higher levels of insulin, testosterone, PSA, and cholesterol correlate with a higher risk of prostate cancer, and also with a higher grade of the disease.

show abstract

Section: Methodsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Significant Association of Metabolic Indices, Lipid Profile, and Androgen Levels with Prostate Cancer

Tewari

Chhabra²,

Natu³

et al. 2014

Asian Pacific Journal of Cancer Prevention

Self Cite

View full text Add to dashboard Cite

show abstract

“…The peripostate adiposity measurement parameter on MRI was superior to the waist circumference (WC) and waist-to-hip ratio (WHR) as a marker of the abdominal obesity. The CRP, IL-6 and Leptin is statically elevated with advancing risk of prostate cancer, supporting that CRP, IL-6 and Leptin appear to have stimulating effect on the promotion and progression of prostate cancer (Tewari et al, 2013); The CRP, IL-6 and Leptin was associated with the PFA and Ratio, but not relevant with the BMI, suggesting periprostate adipose influenced the promotion and progression of the prostate cancer by producing the adipocytokines such as IL-6, Leptin and CRP.…”

Section: Discussionmentioning

confidence: 80%

Influence of Adipocytokines and Periprostatic Adiposity Measurement Parameters on Prostate Cancer Aggressiveness

Qiang¹,

Sun²,

Qi³

et al. 2014

Asian Pacific Journal of Cancer Prevention

View full text Add to dashboard Cite

Background: The relationship between obesity and prostate cancer aggressiveness is controversial in recent studies, partly because BMI is the only generally applied marker of obesity. Our study aimed at evaluating the correlation of periprostatic fat (PF) on magnatic resonance imaging (MRI) and adipocytokines with prostate cancer aggressiveness. Patients and method: A total of 184 patients who underwent radical retropubic prostatectomy (RRP) were analyzed retrospectively; different fat measurements on MRI slices and levels of adipocytokines were compared with the clinical and pathologic factors using SSPS ver.13.0. Result: The PF rates showed a statistically significant variation (p=0.019, 0.025) among groups, that is to say, more adipose tissue was distributed in periprostatic areas of high risk patients. Logistic regression analysis adjusted for age revealed a statistically association between the PF, the ratio and the risk of having high-risk disease (p=0.031, 0.024). The levels of IL-6, leptin and c-reactive protein (CRP) significantly increased with the aggressiveness of prostate cancer, and also with PF and its ratio. The strongest correlation was seen between IL-6 and PF (Pearson r coefficient=0.67, P<0.001). No association was observed between adipocytokines and BMI. Conclusion: Periprostatic adiposity not only affects prostate cancer aggressiveness, but also influences the secretion of adipocytokines. IL-6, PF and CRP have promoting effects on progression of prostate cancer.

show abstract

“…Therefore, it has been suggested that the increased expression of leptin is related to the progression and degree of malignancy of this disease 8,9 .…”

Section: Introductionmentioning

confidence: 99%

Leptin and leptin receptor expressions in prostate tumors may predict disease aggressiveness?

et al. 2014

View full text Add to dashboard Cite

PURPOSE:The aim of this study was to evaluate the expression of leptin and its receptor in histological sections of prostate tumors, and their association with prognostic factors. METHODS:A total of 532 surgical specimens from prostate cancer were studied. After histopathological diagnosis, the samples were included in tissue microarrays containing cores from tumor and non-tumor (benign prostatic hyperplasia) areas. These were immunostained with anti-leptin and anti-leptin-receptor antibodies. Objective and subjective analyses were performed. Student's-t-test and ANOVA were used to compare mean values, and linear regression was used to evaluate the correlation between histological results and prognostic indicators. RESULTS:Leptin receptor expression was reduced in tumors with a positive surgical margin, urethral margin involvement, and seminal vesicles invasion. Further, there was a negative correlation between the expression of leptin receptor in tumor areas and the sum of prognostic factors, suggesting that leptin receptor may predict the aggressiveness of disease. CONCLUSION:Our findings suggest that leptin receptor expression is a potential prognostic factor for PCa. Further investigation is needed to support the use of leptin receptor as a novel biomarker, although leptin itself does not seem to predict the aggressiveness of prostate cancer.

show abstract

Significance of obesity markers and adipocytokines in high grade and high stage prostate cancer in North Indian men – A cross-sectional study

Cited by 25 publications

References 32 publications

Significant Association of Metabolic Indices, Lipid Profile, and Androgen Levels with Prostate Cancer

Significant Association of Metabolic Indices, Lipid Profile, and Androgen Levels with Prostate Cancer

Influence of Adipocytokines and Periprostatic Adiposity Measurement Parameters on Prostate Cancer Aggressiveness

Leptin and leptin receptor expressions in prostate tumors may predict disease aggressiveness?

Contact Info

Product

Resources

About