Significance of Oval Fat Bodies in Urinary Sediment

Quinn, John R.; Zimmerman, Hyman J.

doi:10.1093/ajcp/24.7.787

Cited by 13 publications

(3 citation statements)

References 0 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…There is good evidence that proximal tubular uptake of filtered lipids does occur. Oval fat bodies are fat-laden tubular epithelial cells that are seen in the urinary sedi ment in nephrotic syndrome [113][114][115][116][117], They occur in such a high percentage of nephrotic urines (89% in one study) that they have been included in some definitions of the syndrome [115]. Their numbers correlate with the lev el of proteinuria [114], suggesting that with heavier pro teinuria more lipids are ingested by the proximal tubule.…”

Section: Proximal Tubular Uptake Of Lipids In the Nephrotic Syndromementioning

confidence: 99%

Contribution of Proteinuria to Progressive Renal Injury: Consequences of Tubular Uptake of Fatty Acid Bearing Albumin

Thomas

Schreiner²

1993

Am J Nephrol

112

View full text Add to dashboard Cite

Proteinuria is a marker of a poor prognosis in the glomerulonephritides and progressive renal disease. Recent animal studies have directly implicated proteinuria in inflammatory tubulointerstitial injury. The proximal tubule takes up significant amounts of lipid in the human nephrotic syndrome. We propose that proximal tubular uptake and metabolism of lipids, notably fatty acid bearing albumin, contributes to the chronic tubulointerstitial infiltration and injury associated with heavy proteinuria. Work in our laboratory has shown that a novel nonpolar lipid released by proximal tubules endocytosing fatty acid-bearing albumin is a potent macrophage chemoattractant. We have also studied the metabolic destiny of fatty acids liberated upon proximal tubular catabolism of albumin. Palmitate was preferentially metabolized to phosphatidylcholines, phosphatidylinositols and diglycerides. Oleate and linoleate were metabolized to triglycerides. Palmitate was profoundly inhibitory to OK cell growth, whilst oleate was stimulatory. In nephrosis, faced with an unregulated influx of fatty acids on albumin, the proximal tubule metabolizes them to a variety of lipids, some of which have pathological effects. Thus, the metabolism of albumin-bound fatty acids by the proximal tubule during heavy proteinuria may directly underlie subsequent tubulointerstitial inflammation and altered response to injury.

show abstract

Section: Proximal Tubular Uptake Of Lipids In the Nephrotic Syndromementioning

confidence: 99%

Contribution of Proteinuria to Progressive Renal Injury: Consequences of Tubular Uptake of Fatty Acid Bearing Albumin

Thomas

Schreiner²

1993

Am J Nephrol

112

View full text Add to dashboard Cite

show abstract

“…Fogazzi et al en el 2008 establecieron que la hematuria dismórfica mayor del 40% está asociada con padecimientos glomerulares 13 . Adicionalmente reportamos la presencia de cuerpos ovales grasos en ambos sujetos, los cuales son signo inequívoco de enfermedad renal severa y frecuentemente se asocian al síndrome nefrótico 5,14 .…”

Section: Discussionunclassified

Presencia de células tubulares renales reactivas en pacientes con enfermedad renal crónica

Martínez-Figueroa

Cortés-Sarabia

Catalán-Nájera

et al. 2020

Rev. Colomb. Nefrol.

View full text Add to dashboard Cite

ResumenEn pacientes con enfermedad renal se ha reportado la presencia de células renales reactivas, cuyas alteraciones morfológicas severas dificultan su clasificación e interpretación. El conocimiento de las características morfológicas y los patrones de sedimentos en donde se presentan pueden ser de ayuda para su manejo en los departamentos médicos correspondientes. Aquí, nosotros reportamos la presencia de células agrupadas en acinos, con abundante citoplasma, cariomegalia, contornos nucleares irregulares y nucléolos prominentes, acompañados de cilindruria y cuerpos ovales grasos en el sedimento urinario de dos pacientes con diabetes mellitus, las cuales fueron sugestivas de células renales reactivas.

show abstract

“…Reports on Fabry's disease (ACD) have often noted characteristic mulberry cells (oval fat bodies) in urine, exhibiting 'Maltese cross' with polarized light (1)(2)(3)(4)(5). None of them, however, have noted that cells of similar morphology also appear in urine samples in several other diseases; nephrotic syndrome, lupus nephritis, periarteritis nodosa, scleroderma, diabetic glomerulonephritis, amyloid nephritis, chronic glomerulonephritis, and other diseases (13,14). Takahashi and Ito, in their monograph on urinary sediments, described oval fat bodies with a 'Maltese cross' in nephrotic syndrome, Alport's syndrome and Fabry's disease (15).…”

Section: Discussionmentioning

confidence: 99%

Concentric Lamellar Spheres in Urine From a Female Carrier of and Patients With Fabry's Disease

Nagao

Satoh

Inaba

et al. 1985

The Journal of Dermatology

View full text Add to dashboard Cite

In urine samples of patients with Fabry's disease (angiokeratoma corporis diffusum, ACD) mulberry cells appear, exhibiting the ‘Maltese cross’ with polarized light; they are said to be characteristic of this disease. However, their diagnostic significance has never been clearly defined. It is also well known that patients with this disease have electron‐dense periodical lamellar bodies in the cells of various organs. Several electron microscopic investigations have demonstrated such lamellar bodies in urine samples from hemizygous male patients, but it remains unclarified whether heterozygous female carriers excrete similar bodies in urine. We examined urine samples from a female carrier of ACD and two hemizygotes with the disease, as well as from three patients with nephrotic syndrome. With the light microscope, mulberry cells with ‘Maltese cross’ were detected in all six patients, suggesting that these cells are not diagnostic for ACD. With the electron microscope, concentric lamellar spheres were found in the heterozygous female carrier and two hemizygous males, but not in patients with nephrotic syndrome. This is the first report describing urinary laminated bodies in a female carrier of ACD. It is concluded that the demonstration of mulberry cells with ‘Maltese cross’ as well as concentric lamellar bodies in urine is helpful in detecting female carriers of ACD and hemizygotes as young as 7 years of age, before they exhibit definite clinical manifestations.

show abstract

Significance of Oval Fat Bodies in Urinary Sediment

Cited by 13 publications

References 0 publications

Contribution of Proteinuria to Progressive Renal Injury: Consequences of Tubular Uptake of Fatty Acid Bearing Albumin

Contribution of Proteinuria to Progressive Renal Injury: Consequences of Tubular Uptake of Fatty Acid Bearing Albumin

Presencia de células tubulares renales reactivas en pacientes con enfermedad renal crónica

Concentric Lamellar Spheres in Urine From a Female Carrier of and Patients With Fabry's Disease

Contact Info

Product

Resources

About