Significance of plasma osteopontin in diagnosis of hepatitis C virus-related hepatocellular carcinoma

Nabih, Mona I.; Aref, Wael; Fathy, Mona

doi:10.1016/j.ajg.2014.08.002

Cited by 14 publications

(13 citation statements)

References 23 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Furthermore, we showed that the performance of OPN remained intact a year prior to HCC diagnosis in this high risk group (8, 9). The performance of OPN for the early detection of HCC was further validated in independent studies (10–12). OPN is an extracellular matrix protein that has been implicated in several carcinogenic and angiogenic processes, such as cell invasion, inflammation, tumor progression, and metastasis (13, 14).…”

Section: Introductionmentioning

confidence: 96%

Circulating Osteopontin and Prediction of Hepatocellular Carcinoma Development in a Large European Population

Duarte‐Salles

Misra

Stępień

et al. 2016

Cancer Prevention Research

View full text Add to dashboard Cite

We previously identified osteopontin (OPN) as a promising marker for the early detection of hepatocellular carcinoma (HCC). In this study, we investigated the association between pre-diagnostic circulating OPN levels and HCC incidence in a large population-based cohort. A nested-case control study was conducted within the EPIC cohort. During a mean follow-up of 4.8 years, 100 HCC cases were identified. Each case was matched to two controls and OPN levels were measured in baseline plasma samples. Viral hepatitis, liver function and alpha-fetoprotein (AFP) tests were also conducted. Conditional logistic regression models were used to calculate multivariable odds ratio (OR) and 95% confidence intervals (95%CI) for OPN levels in relation to HCC. Receiver operating characteristics curves were constructed to determine the discriminatory accuracy of OPN alone or in combination with other liver biomarkers in the prediction of HCC. OPN levels were positively associated with HCC risk (per 10% increment, ORmultivariable=1.30; 95%CI:1.14–1.48). The association was stronger among cases diagnosed within two years of follow-up. Adding liver function tests to OPN improved the discriminatory performance for subjects who developed HCC (AUC=0.86). For cases diagnosed within two years, the combination of OPN and AFP was best able to predict HCC risk (AUC=0.88). The best predictive model for HCC in this low-risk population is OPN in combination with liver function tests. Within two years of diagnosis, the combination of OPN and AFP best predicted HCC development, suggesting that measuring OPN and AFP could identify high-risk groups independently of a liver disease diagnosis.

show abstract

Section: Introductionmentioning

confidence: 96%

Circulating Osteopontin and Prediction of Hepatocellular Carcinoma Development in a Large European Population

Duarte‐Salles

Misra

Stępień

et al. 2016

Cancer Prevention Research

View full text Add to dashboard Cite

show abstract

“…Subsequently, plasma concentrations of OPN measured in cirrhotic patients, with and without HCC, revealed significantly higher concentrations in individuals with HCC compared with those without tumors. Recently, Nabih et al [31] suggested OPN as a tumor marker, which could be used as a screening test for the diagnosis of HCC in patients with liver cirrhosis caused by the hepatitis C virus. No relationship of plasma OPN or HVPG levels to occurrence of HCC was found in our cohort of patients.…”

mentioning

confidence: 99%

Osteopontin: A non-invasive parameter of portal hypertension and prognostic marker of cirrhosis

Brůha

Jáchymová

Petrtýl

et al. 2016

WJG

View full text Add to dashboard Cite

“…Patients with HCC bear a high rate of mortality and the therapeutic options are very limited due to a lack of knowledge about the mechanisms of HCC development and progression. OPN, as well as Wnt signaling pathway, are associated with HCV 33,46 and tumor development 47,18 .…”

Section: Aim Of the Studymentioning

confidence: 99%

“…OPN is known to be induced in HCV patients 33 and up-regulated in human HCC, therefore it is used as a diagnostic tumor marker 47 . Increased OPN levels are related to higher metastatic potential and poor prognosis.…”

Section: Opn Expression Is Up-regulated In Mice With Hcv Infection Ormentioning

confidence: 99%

“…As the Wnt signaling pathway is activated by OPN ( Figure 14 It was shown that OPN can be induced in HCC 47 and that an increased OPN level is related to higher metastatic potential and poor prognosis 50 . This thesis shows increased, but inhomogeneous OPN levels in murine liver tumors ( Figure 9) and the human hepatoma cell lines HepG2 and Huh7 ( Figure 10).…”

Section: Opn Does Not Regulate Viability Although It Increases Wnt Simentioning

confidence: 99%

See 1 more Smart Citation

Mechanisms of osteopontin-mediated effects on chronic hepatic inflammation and cancer

et al. 2015

View full text Add to dashboard Cite

Significance of plasma osteopontin in diagnosis of hepatitis C virus-related hepatocellular carcinoma

Cited by 14 publications

References 23 publications

Circulating Osteopontin and Prediction of Hepatocellular Carcinoma Development in a Large European Population

Circulating Osteopontin and Prediction of Hepatocellular Carcinoma Development in a Large European Population

Osteopontin: A non-invasive parameter of portal hypertension and prognostic marker of cirrhosis

Mechanisms of osteopontin-mediated effects on chronic hepatic inflammation and cancer

Contact Info

Product

Resources

About