Significance of Plasma Retinol Binding Protein Levels in Recurrence of Breast Tumors in Women

Mehta, Rajeshwari R.; Hart, Gloria; Beattie, Craig W.; Gupta, Tapas K. Das

doi:10.1159/000226510

Cited by 11 publications

(6 citation statements)

References 16 publications

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“…It is noteworthy that in the present study the serum RBP was the only parameter found to be significantly lower in breast cancer patients when compared with the healthy subjects or the patients with benign breast disease. These results are in agreement with others who found an association between low plasma RBP and recurrence of either breast cancer [30] or colorectal cancer [4] in patients receiving adjuvant chemotherapy. RBP is known to be highly sensitive to an inadequate protein intake, because of its rapid turnover rate and unusually high tryptophan content [31].…”

Section: Discussionsupporting

confidence: 93%

Serum vitamins A and E, beta-carotene, and selenium in patients with breast cancer.

Basu¹,

Hill²,

Ng³

et al. 1989

Journal of the American College of Nutrition

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A total of 89 subjects including 30 breast cancer patients with distal metastases, 29 patients with benign breast disease, and 30 healthy subjects were studied. Serum samples from these subjects were obtained from the National Cancer Institute (NCI) Breast Cancer Serum Bank, Bethesda. Serum concentrations of vitamin A and its transport proteins (prealbumin and retinol-binding protein [RBP]), beta-carotene, vitamin E, and selenium were determined. For each of these parameters the mean for the breast cancer patients was lower than that of the healthy subjects. The differences between healthy subjects and patients with either breast cancer or benign breast disease were, however, statistically significant only in the case of RBP (p less than 0.05). In the case of vitamin A and its transport proteins these differences were reduced by comparing the cancer patients with the benign breast disease patients rather than with the healthy controls. This indicates that the low serum levels for those three parameters may be merely a consequence of disease in general rather than a feature of cancer per se.

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Section: Discussionsupporting

confidence: 93%

Serum vitamins A and E, beta-carotene, and selenium in patients with breast cancer.

Basu¹,

Hill²,

Ng³

et al. 1989

Journal of the American College of Nutrition

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“…Prealbumin is considered as important as albumin in the nutritional assessment. It is of interest that serum prealbumin has been reported to reflect changes in the cancer patient's clinical status in some studies (20)(21)(22)(23). The key observations made in this study can be summarized as follows: 1) low preoperative prealbumin and albumin were associated with early disease recurrence in patients with operable colorectal cancer; 2) among various clinicopathological characteristics, only a low serum albumin was independently associated with early disease recurrence; 3) low serum prealbumin lost its significance on multivariate analysis that included serum albumin.…”

Section: Discussionmentioning

confidence: 99%

Serum Albumin Is Superior to Prealbumin for Predicting Short-Term Recurrence in Patients with Operable Colorectal Cancer

Fujii

Sutoh

Morita

et al. 2012

Nutrition and Cancer

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The relationship between preoperative prealbumin and cancer survival has not been fully elucidated. The purpose of this study was to examine the relationship between preoperative nutritional conditions, including prealbumin and albumin concentrations, and the risk of recurrence in cases with operable colorectal carcinoma. One hundred fifty-eight patients who underwent elective colorectal resection were analyzed in this study. Of the eligible cases, 56 (35.4%) had decreased serum prealbumin and 15 (9.5%) had decreased serum albumin preoperatively. Among 158 cases in this study, 18 (11.4%) had disease recurrence. In the univariate analysis, the depth of tumor invasion, lymph node metastasis, lymphovascular invasion, serum albumin, prealbumin, and carcinoembryonic antigen were the factors significantly associated with disease recurrence. Multivariate analysis demonstrated that only serum albumin was a predictor of the recurrence; however, serum prealbumin lost its significance on multivariate analysis. Time to tumor recurrence by Kaplan-Meier curves significantly differed among patients with low serum albumin and prealbumin level. Our results suggest that prealbumin and albumin may be sensitive indicators of the risk of recurrent disease; however, low serum albumin levels are more useful than prealbumin in predicting short-term disease recurrence in operable colorectal cancer.

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“…We found only one study that looked at the influence of retinol on breast cancer prognosis (18). The study found that in premenopausal women with node-positive breast cancer receiving adjuvant chemotherapy, significantly low levels of retinol-binding protein (RBP; also known as RBP4; ref.…”

Section: Introductionmentioning

confidence: 99%

Plasma Retinol and Prognosis of Postmenopausal Breast Cancer Patients

Formelli

Meneghini

Cavadini

et al. 2009

Cancer Epidemiology, Biomarkers &Amp; Prevention

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Background: The role of retinol (vitamin A) in breast cancer prognosis has never been investigated in postmenopausal women. We prospectively assessed the long-term prognostic role of retinol plasma levels in a cohort of postmenopausal breast cancer patients. Patients and Methods: We investigated 208 women selfreported as postmenopausal operated on for T 1-2 N 0 M 0 breast cancer who participated in a chemoprevention trial as controls and never received chemotherapy or hormone therapy. Plasma samples were collected 3 months (median) after surgery and assayed within 3 weeks for retinol. Minimum and median potential follow-up were 12 and 15 years, respectively. The main analyses were on all women and on a subgroup ages z55 years, assumed too old to be in perimenopause. The main end point was breast cancer death. Breast cancer survival was estimated by the Kaplan-Meier

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Significance of Plasma Retinol Binding Protein Levels in Recurrence of Breast Tumors in Women

Cited by 11 publications

References 16 publications

Serum vitamins A and E, beta-carotene, and selenium in patients with breast cancer.

Serum vitamins A and E, beta-carotene, and selenium in patients with breast cancer.

Serum Albumin Is Superior to Prealbumin for Predicting Short-Term Recurrence in Patients with Operable Colorectal Cancer

Plasma Retinol and Prognosis of Postmenopausal Breast Cancer Patients

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