Significance of positive margins in oral cavity squamous carcinoma

Loree, Thom R.; Strong, Elliót W.

doi:10.1016/s0002-9610(05)80555-0

Cited by 368 publications

(294 citation statements)

References 8 publications

Supporting

Mentioning

266

Contrasting

Unclassified

Order By: Relevance

“…Similarly, we found no significant differences in locoregional recurrence between patient groups for negative (28/119, or 23.5%) and close margins (\5 mm, 4/30 or 13%), after the exclusion of 19 patients with frankly positive (''cut through'') margins [25]. The local recurrence rates for patients with inadequate margins in these two studies [25,33] are better than for the corresponding inadequate margin groups in the previous studies [28,29], although the same 5 mm margin standard was used. Why would some ''inadequate'' resection margins be associated with better outcome than others?…”

Section: The Prognostic Significance Of Resection Marginsmentioning

confidence: 91%

“…Using the definition of ''tumor cut-through'' for positive margins, Byers [27] reported on 216 patients, and demonstrated local recurrence rates of 80% in the positive margin group, compared to 12-18% in the negative margin group. The definition of C5 mm for margin adequacy is a common standard, and was used in the following statistically significant studies [28][29][30][31]. Chen reported on 270 patients and demonstrated locoregional recurrence of 55 versus 17%, and 5-year disease-free survival of 7 versus 39%, for inadequate, versus negative margin groups, respectively [28].…”

Section: The Prognostic Significance Of Resection Marginsmentioning

confidence: 99%

“…Chen reported on 270 patients and demonstrated locoregional recurrence of 55 versus 17%, and 5-year disease-free survival of 7 versus 39%, for inadequate, versus negative margin groups, respectively [28]. Loree reported on 303 patients and demonstrated locoregional recurrence of 30 versus 18%, and 5-year overall survival of 52 versus 60%, for inadequate, versus negative margin groups, respectively [29]. Garzino [30] reported on 245 patients and demonstrated 5-year overall survival of 48 versus 65%, for inadequate, versus negative margin groups, respectively.…”

Section: The Prognostic Significance Of Resection Marginsmentioning

confidence: 99%

See 2 more Smart Citations

Prognostic Indicators in Head and Neck Oncology Including the New 7th Edition of the AJCC Staging System

Brandwein-Gensler

Smith

2010

Head and Neck Pathol

View full text Add to dashboard Cite

Section: The Prognostic Significance Of Resection Marginsmentioning

confidence: 91%

Section: The Prognostic Significance Of Resection Marginsmentioning

confidence: 99%

Section: The Prognostic Significance Of Resection Marginsmentioning

confidence: 99%

See 1 more Smart Citation

Prognostic Indicators in Head and Neck Oncology Including the New 7th Edition of the AJCC Staging System

Brandwein-Gensler

Smith

2010

Head and Neck Pathol

View full text Add to dashboard Cite

“…Close margin on initial resection was reported about 42 % by various authors [9,10]. Byers et al [11] found that the surgeon was able to obtain clear margins in 67 % cases only.…”

Section: Discussionmentioning

confidence: 99%

Prognostic Value of Frozen Section in T1, T2 Carcinoma of Oral Cavity

Gokavarapu

Rao

Patnaik

et al. 2014

Indian J Otolaryngol Head Neck Surg

View full text Add to dashboard Cite

Complex anatomy of oral cavity makes it difficult for a surgeon to assess margins of oral cancer accurately and positive margins compromise loco regional disease control, thus surgeon may rely on frozen section assessment for marginal status. We discussed the prognostic value of frozen section in early carcinoma of oral cavity. 90 patients with pT1 and pT2 oral cavity cancer operated from January 2010 to December 2011 under single consultant surgeon were retrospectively evaluated. Log rank test and multivariate cox regression model was used for testing frozen section against the survival and recurrence free status. Survival of patients with positive or negative frozen section was significant (p = 0.037), Survival of patients with positive or negative histology report was significant (p = 0.004), however; prognosis of patients with positive margins despite revision under frozen control was poorer to the patients with negative margin. Frozen section assessment is accurate but their use in the surgery of oral cavity cancer might not improve loco regional disease control or survival when used routinely.

show abstract

“…It has been shown that failure to achieve a clear surgical margin results in increased risk of local recurrence and a subsequent reduced chance of survival. [1][2][3][4] To ensure complete resection of the tumor, frozen-section analysis, including Moh's micrographic technique, 5 is employed in some units. Some researchers have advocated that frozen-section examination for margin assessment is a reliable technique to control the extent of cancer surgery; [6][7][8][9] however, this approach has some problems as it is time consuming, costly, and sometimes stressful.…”

Section: Introductionmentioning

confidence: 99%

Accuracy of intraoperative tissue staining in delineating deep surgical margins in oral carcinoma surgery

Kitamura¹,

Sakai²,

Kamata³

et al. 2008

Oral Oncology

View full text Add to dashboard Cite

Abstract:The purpose of this study was to assess the accuracy of this tissue staining assessment of surgical specimens in delineating deep surgical margins in oral cancer surgery. Fifteen patients who underwent surgery for oral carcinoma were included in the study. Once the tumor was resected, a vertical section of the surgical specimen was taken from the central part of the tumor. The section was consecutively stained with 0.4% indigo carmine and 0.5% Congo red, and deep surgical margins were assessed using a digital microscope with a magnification power of 25 to 175x. The results of tissue-staining analysis were compared with the corresponding results of conventional histopathological analysis with HE staining, which is considered the gold standard. The extent of carcinoma invasion could be visualized after the application of tissue-staining solutions. Tissue-staining analysis was accurate in 12 of the 15 patients (80%) in evaluating the closest deep surgical margin. There was no significant difference in the tumor-margin distance between tissue staining and histopathological assessment in these 12 patients (Wilcoxon signed-ranks test, P>0.63). The results of this study showed that intraoperative tissue staining of surgical specimens permitted visual inspection and assessment of tumor spread to surgical margin, although the method has some limitations. The method had a possible ability in controlling the deep surgical margin.

show abstract

Significance of positive margins in oral cavity squamous carcinoma

Cited by 368 publications

References 8 publications

Prognostic Indicators in Head and Neck Oncology Including the New 7th Edition of the AJCC Staging System

Prognostic Indicators in Head and Neck Oncology Including the New 7th Edition of the AJCC Staging System

Prognostic Value of Frozen Section in T1, T2 Carcinoma of Oral Cavity

Accuracy of intraoperative tissue staining in delineating deep surgical margins in oral carcinoma surgery

Contact Info

Product

Resources

About