Significance of pre and post-implant MELD-XI score on survival in children undergoing VAD implantation

Boyle, Gerard J.; Cantor, Ryan S.; Conway, Jennifer; Godown, Justin; Kirklin, James K.; Koehl, Devin; Lal, Ashwin K.; Law, Yuk M.; Lorts, Angela; Rosenthal, David N.

doi:10.1016/j.healun.2021.08.013

Cited by 6 publications

(2 citation statements)

References 25 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…71 Chronic kidney injury has the potential to worsen HF and increase the risk of adverse events with pharmacological or advanced HF therapies. 14,72,73 Patients with congenital heart disease lesions associated with elevated central venous pressures such as those with Fontan circulation, Ebstein anomaly, lesions with significant RV dysfunction, or tricuspid insufficiency are at risk for cirrhosis and hepatocellular carcinoma. 74 The presence of liver dysfunction can potentially increase the risk of adverse events associated with pharmacological therapies and morbidity and mortality after ventricular assist device implantation or heart transplantation.…”

Section: Comorbidities and Hf In Congenital Heart Diseasementioning

confidence: 99%

See 1 more Smart Citation

Evaluation and Management of Chronic Heart Failure in Children and Adolescents With Congenital Heart Disease: A Scientific Statement From the American Heart Association

Amdani,

Conway,

George

et al. 2024

Circulation

Self Cite

View full text Add to dashboard Cite

With continued medical and surgical advancements, most children and adolescents with congenital heart disease are expected to survive to adulthood. Chronic heart failure is increasingly being recognized as a major contributor to ongoing morbidity and mortality in this population as it ages, and treatment strategies to prevent and treat heart failure in the pediatric population are needed. In addition to primary myocardial dysfunction, anatomical and pathophysiological abnormalities specific to various congenital heart disease lesions contribute to the development of heart failure and affect potential strategies commonly used to treat adult patients with heart failure. This scientific statement highlights the significant knowledge gaps in understanding the epidemiology, pathophysiology, staging, and outcomes of chronic heart failure in children and adolescents with congenital heart disease not amenable to catheter-based or surgical interventions. Efforts to harmonize the definitions, staging, follow-up, and approach to heart failure in children with congenital heart disease are critical to enable the conduct of rigorous scientific studies to advance our understanding of the actual burden of heart failure in this population and to allow the development of evidence-based heart failure therapies that can improve outcomes for this high-risk cohort.

show abstract

Section: Comorbidities and Hf In Congenital Heart Diseasementioning

confidence: 99%

“…74 The presence of liver dysfunction can potentially increase the risk of adverse events associated with pharmacological therapies and morbidity and mortality after ventricular assist device implantation or heart transplantation. 14,72…”

Section: Comorbidities and Hf In Congenital Heart Diseasementioning

confidence: 99%