Significance of screening antibodies to hepatitis B virus core antigen among Syrian blood donors

Muselmani, W.; Habbal, Wafa; Monem, Fawza

doi:10.1111/tme.12043

Cited by 11 publications

(11 citation statements)

References 15 publications

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“…Evidently, hepatitis seroprevalence among multitransfused patients is reflected by the seroprevalence among healthy blood donors 12. This is underlined by the consistency of our findings among multitransfused patients (HBsAg, 0.62%; anti-HBc, 12.5%) with a previous report on HBV seroprevalence among Syrian blood donors (HBsAg, 1.3%; anti-HBc, 11.2%,7 which coincides with other countries such as Jordan,2 Iran1,13 and Pakistan 14…”

Section: Discussionsupporting

confidence: 88%

“…Viral nucleic acids were extracted using MagNA Pure Compact Nucleic Acid Isolation kit (Roche Diagnostics, Mannheim, Germany) according to the manufacturer’s instructions. HBV DNA and HCV RNA were detected by real-time PCR using LC-FastStart DNA Master HybProbe and LC-RNA Master HybProbe kits, respectively, on the LightCycler instrument (Roche Diagnostics, Mannheim, Germany) as previously described 7,9…”

Section: Methodsmentioning

confidence: 99%

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Seropositivity of Hepatitis B and C among Syrian Multitransfused Patients

Yazaji

Habbal

Monem

2016

Mediterr J Hematol Infect Dis

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Background and objectivesBlood transfusion is a lifesaving therapy for patients with hemoglobinopathies. However, the need of frequent transfusion carries the risk of transmitting hepatitis B and C infections which are intermediately prevalent in Syria. Despite screening blood donations with sensitive methods, the risk of transmission is still present when infectious blood is donated within the window period. This study aimed to investigate the incidence of HBV and HCV seropositivity, and its association with multiple transfusions among Syrian hemoglobinopathies patients.Materials and MethodsHBsAg, anti-HBc, anti-HBs and anti-HCV were tested for 159 Syrian multi-transfused patients by Enzyme-Linked Immunosorbent Assay (ELISA).ResultsThirty-nine of 159 (24.5%) multi-transfused patients were HBsAg/anti-HBc or anti-HCV positive, 26 (16%) of which never visited the dentist, and they either tested postsurgically negative for HBsAg and anti-HCV or never underwent a surgical procedure. On the contrary of anti-HCV seropositivity, HBsAg/anti-HBc seropositivity was significantly associated with the number of blood transfusions, number of blood units and age (P < 0.001).ConclusionAbout one-sixth of our patients most likely acquired HBV/HCV infection via blood transfusion. Administering HBV vaccine, ensuring the immune status, and monitoring hepatitis markers might considerably minimize the incidence of viral hepatitis among multi-transfused patients.

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Section: Discussionsupporting

confidence: 88%

Section: Methodsmentioning

confidence: 99%

Seropositivity of Hepatitis B and C among Syrian Multitransfused Patients

Yazaji

Habbal

Monem

2016

Mediterr J Hematol Infect Dis

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“…The prevalence of hepatitis B is 1.7% and the prevalence of hepatitis C is 0.4% in Syrian refugees. While these results are very similar to the results of the studies on blood donors in Syria, they are found to be lower than the 4.2% HBsAg seropositivity and 1.0% anti-HCV seropositivity values determined by [25,26] Koruk et al in their study in the city center of Şanlıurfa in 2008 [14]. The rate of Anti-HBs positivity is 9.4% in blood donors in Syria and 25.2% in Syrian refugees.…”

Section: Discussionsupporting

confidence: 84%

Syrian Refugees at Risk of Hepatitis Diseases in Turkey, in Şanliurfa?

Keklik¹,

Koruk²,

Allahverdi³

2019

SJM

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Aim:The aim of this study is to determine the prevalence of hepatitis B/C diseases among Syrian refugees living outside the temporary accommodation centers in Şanlıurfa city center, and individuals' levels of knowledge and risky behaviors related to these diseases. Methods: The research is cross-sectional. It was carried out with 473 Syrian refugees who were living in Şanlıurfa city center outside the temporary accommodation centers in April 2015 -2016. Cluster sampling method was preferred in the selection of the sample. The questionnaire form, which was prepared by the researchers, was applied, and a venous blood sample was collected from the individuals during data collection. HBsAg, Anti-HBs, Anti-HBc total and Anti-HCV levels of the blood samples were examined. Descriptive statistics, Chi-square, and Mann-Whitney U tests were used in the evaluation of the data. Statistical analyses were performed at 95% confidence level. p<0.05 value was accepted as statistically significant. Results: Of the Syrians, 62.2% were women and 37.8% men, with a median age of 34.0. 25.6% of participants had never attended school, and 82.2% of them were married. 57.3% of asylum seekers were Arabian, and 41.9% were Kurdish. 80.1% of them didn't know enough Turkish to communicate. Participants' average monthly income was 171$. An average of 8.6 individuals was living in the household, and the individual/room rate was 3.2. 60.3% of Syrian refugees had not heard of hepatitis B disease, and 69.1% of them had not heard of hepatitis C disease. Only 2.3% (n=11) of the individuals correctly answered all the questions about the transmission and prevention of hepatitis B/C diseases. 1.7% of Syrian refugees were HBsAg positive, 23.9% were Anti-HBc total positive, and 0.4% of them were Anti-HCV positive. 25.2% of Syrian refugees were anti-HBS positive, while 7.1% were immunized with the hepatitis B vaccine. There was no statistically significant difference in the distribution of HBsAg and Anti-HCV antibody status of Syrian refugees according to socio-demographic characteristics and risky behaviors used in this study (p>0.05). Anti-HBc total antibody positivity was higher in males, in those over 50 years of age, in those who had never attended school and in those who had married at least once (p<0.05). Anti-HBc total positivity was higher in women, especially in those who had given birth at least once (p<0.05). Conclusions: The prevalence of hepatitis B/C in Syrian refugees was lower than in Turkey. This suggests that Syrian refugees are at more risk than individuals in our country. Low immunization rates also support this situation. It is believed that the risk of transmission of hepatitis B/C diseases can be reduced by giving information about the transmission and prevention ways of hepatitis B/C diseases to individuals at marriage age, by screening the group at risk and immunizing them against hepatitis B, increasing the rate of condom use in case of risky sexual intercourse, increasing education level, regular antenatal care of pregnant women...

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“…In Muselmani et al study done in AL Assad university hospital on the blood donors (2013), they found the prevalence of HBV to be 1.3 % [25], which is lower than in our study, probably this is because of the war that happened in that country since 2013 with near complete collapse of the health system. Beside this since beginning of the war in Syria hundreds of mass casualties had happened in the country with a large numbers of injuries, operations and blood transfusions.…”

Section: Discussioncontrasting

confidence: 79%

Epidemiological Study of Hepatitis B, C and HIV Cases among the Foreigners Visiting Sulaimani City from 2013 Through 2016

Mohammed

Hasan

Maarouf

2019

KJAR

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Hepatitis B, C and HIV infections present a great public health problem worldwide. More than 350 million of world's populations have chronic HBV infection and near 1 million people are dying due to this infection each year. About 150-200 million of world's population have chronic HCV infection that leads to nearly 350 000 deaths annually. On the other hand HIV remains as a major global public health issue. In 2015, about 36.7 million people were living with HIV and 1.1 million people died of HIV related illnesses. To find the prevalence of HB, HCV and HIV infection among the foreigners who visited Sulaimani city in 2013 through 2016 and evaluate the common risk factors in those who had a positive results in 2016. This study was conducted between 1 st of January 2016 and 31 st December 2016. A total number of 275,979 foreigners who were referred formally to the central laboratory-residency department in Sulaimani city for screening for (HBsAg, HCV Ab and HIV Ab) from 2013 through 2016 were analyzed and all the foreigners who visited Sulaimani city in 2016 were included with assessment of demographic data and risk factors among the positive cases. Among 275,979 foreigners who visited Sulaimani city from 2013 through 2016, theoverall prevalence of HBV infection was0.47%(1318 cases), HCV 0.01 %( 267 cases) and HIV 0.01 %( 30 cases). In 2016 the highest prevalence of HBV infection was among Syrians which was 2.5% while highest HCV prevalence was among Europeans 0.82%. Ages of the patients ranged between (18-65) years, 85.4% were males, 65.2% of males and 45.7% of females were married. Dental procedures, surgery, blood transfusion and family history were common risk factors. HBV infection was highest among Syrian foreigners. While the highest HCV prevalence was among Europeans. An immediate action plan is needed to screen all Syrian refugees in our region for HBV, HCV and HIV to determine active infection and treat accordingly and also impose preventive measures to halt the spread of the infections.

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Significance of screening antibodies to hepatitis B virus core antigen among Syrian blood donors

Cited by 11 publications

References 15 publications

Seropositivity of Hepatitis B and C among Syrian Multitransfused Patients

Seropositivity of Hepatitis B and C among Syrian Multitransfused Patients

Syrian Refugees at Risk of Hepatitis Diseases in Turkey, in Şanliurfa?

Epidemiological Study of Hepatitis B, C and HIV Cases among the Foreigners Visiting Sulaimani City from 2013 Through 2016

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