Significance of Sentinel Lymph Node Micrometastases in Human Breast Cancer

Cox, Charles E.; Kiluk, John V.; Riker, Adam I.; Cox, John M.; Allred, Nathon; Ramos, Daniel; Dupont, Elisabeth; Vrcel, Vesna; Diaz, Nils M.; Boulware, David

doi:10.1016/j.jamcollsurg.2007.08.024

Cited by 138 publications

(106 citation statements)

References 31 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Cox and colleagues have shown that these are two distinct pathologic processes with different prognostic implications. 4 The authors may have had no choice but to combine the two groups in order to provide enough patients to give their study adequate power.…”

mentioning

confidence: 99%

Can Axillary Lymph Node Dissection Be Safely Omitted for Early-Stage Breast Cancer Patients with Sentinel Lymph Node Micrometastasis?

Damle

Teal

2010

Indian J Surg Oncol

View full text Add to dashboard Cite

mentioning

confidence: 99%

Can Axillary Lymph Node Dissection Be Safely Omitted for Early-Stage Breast Cancer Patients with Sentinel Lymph Node Micrometastasis?

Damle

Teal

2010

Indian J Surg Oncol

View full text Add to dashboard Cite

“…The 15-year DFS for the ITC group was worse than the node-negatives (64% vs. 81%, p <0.05; RR 2.0). Cox et al [63] in their cohort, SLN 13 ITC prevalence 6.3% (151 patients), reported a non-SLN rate of 9.3%, again with a majority of macro-metastases. Interestingly, the OS of SLN ITC patients who did not undergo ALND was significantly less than those undergoing ALND (p <0.05).…”

Section: Evidence In Favourmentioning

confidence: 88%

Clinical significance of sentinel lymph node isolated tumour cells in breast cancer

Patani

Mokbel

2011

Breast Cancer Res Treat

View full text Add to dashboard Cite

show abstract

“…Strength of SLNB technique over ALND is its careful and precise evaluation of few specimen by intensive methods as serial sectioning and ImmunoHistoChemistry (IHC) to detect more micrometastasis as well as isolated tumor cells (Lyman et al, 2005). Although detection of nodepositive patients considerably rises at least 10% after introduction of SLNB procedure (van der Heiden-van der Loo et al, 2006), however, importance of these cells and probable effect on outcome and treatment planning is a controversial issue (Cox et al, 2008;Langer et al, 2009;TruongLesperance, 2010)and requires to be answered in ongoing clinical trials as ACOSOG -Z0010 and IBCSG-23-01 (Giuliano et al, 2011;Galimberti, 2006).…”

Section: Discussionmentioning

confidence: 99%

Value of Sentinel Lymph Node Biopsy in Breast Cancer Surgery with Simple Pathology Facilities -An Iranian Local Experience with a Review of Potential Causes of False Negative Results

Amoui

Akbari²,

Tajeddini³

et al. 2012

Asian Pacific Journal of Cancer Prevention

View full text Add to dashboard Cite

Introduction: Sentinel lymph node biopsy (SLNB) is a precise procedure for lymphatic staging in early breast cancer. In a valid SLNB procedure, axillary lymph node dissection (ALND) can be omitted in nodenegative cases without compromising patient safety. In this study, detection rate, accuracy and false negative rate of SLNB for breast cancer was evaluated in a setting with simple modified conventional pathology facilities without any serial sectioning or immunohistochemistry. Material and Method: Patients with confirmed breast cancer were enrolled in the study. SLNB and ALND were performed in all cases. Lymph node metastasis was evaluated in SLN and in nodes removed by ALND to determine the false negative rate. Pathologic assessment was carried out only by modified conventional technique with only 3 sections. Detection rate was determined either by lymphoscintigraphy or during surgery. Results: 78 patients with 79 breast units were evaluated. SLN was detected in 75 of 79 cases (95%) in lymphoscintigraphy and 76 of 79 cases (96%) during surgery. SLN metastases was detected in 30 of 75 (40%) cases either in SLNB and ALND groups. Accuracy of SLNB method for detecting LN metastases was 92%. False negative rate was 3 of 30 of positive cases: 10%. In 7 of 10 cases with axillary lymphadenopathy, LN metastastates was detected. Conclusion: SLNB is recommended for patients with various tumor sizes without palpable lymph nodes. In modified conventional pathologic examination of SLNs, at least macrometastases and some micrometastases could be detected similar to ALND. Consequently, ALND could be omitted in node-negative cases with removal of all palpable LNs. We conclude that SLNB, as one of the most important developments in breast cancer surgery, could be expanded even in areas without sophisticated pathology facilities.Keywords: Breast neoplasm -lymphatic metastasis -lymph node dissection -sentinel lymph node biopsy

show abstract

Significance of Sentinel Lymph Node Micrometastases in Human Breast Cancer

Cited by 138 publications

References 31 publications

Can Axillary Lymph Node Dissection Be Safely Omitted for Early-Stage Breast Cancer Patients with Sentinel Lymph Node Micrometastasis?

Can Axillary Lymph Node Dissection Be Safely Omitted for Early-Stage Breast Cancer Patients with Sentinel Lymph Node Micrometastasis?

Clinical significance of sentinel lymph node isolated tumour cells in breast cancer

Value of Sentinel Lymph Node Biopsy in Breast Cancer Surgery with Simple Pathology Facilities -An Iranian Local Experience with a Review of Potential Causes of False Negative Results

Contact Info

Product

Resources

About