Significance of serum ferritin level in the prediction of delivery of low birth weight newborns for gestational age

Milasinović, L; Visnjevac, Nemanja; Bogavac, Mirjana; Grujić, Zorica; Mladenović-Segedi, Ljiljana; Paunkovic, Jovana

doi:10.2298/sarh1306337m

Cited by 3 publications

(6 citation statements)

References 11 publications

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“…In the present study, the following cutoff points for maternal Hb were set in relation to the occurrence of LBW: 12.6 g/dL (1st trimester), 11.4 g/dL (2nd trimester), and 12.35 g/dL (3rd trimester). Milasinović et al (28) found that pregnant women with Hb values > 11.7 g/dL and ferritin concentrations above 13.6 ng/mL and hematocrit > 32.9% in the 30th to 32nd week of pregnancy were more likely to have restricted intrauterine growth and LBW infants, according to the analysis of the ROC curve. Their proposed cut-off point for Hb was similar to that found in the second trimester of pregnancy (11.4 stages, the production of red blood cells is compromised, and anemia can be detected by hemoglobin concentrations (≤ 11 g/dL in the first and third quarters and ≤ 10.5 g/dL in the second quarter) (30).…”

Section: Discussionmentioning

confidence: 99%

A relação entre as concentrações de hemoglobina durante a gravidez e peso de nascimento / The relationship between hemoglobin concentrations during pregnancy and birth weight

Santana¹,

Barbosa²,

Carmo³

et al. 2021

BJDV

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RESUMOObjetivo: Avaliar a relação entre as concentrações de hemoglobina (Hb) durante a gravidez e o peso ao nascer. Métodos: Estudo transversal envolvendo 1450 gestantes e seus recém-nascidos atendidos em maternidade pública do Rio de Janeiro, Brasil (1999-2014. As concentrações de Hb foram avaliadas nos três trimestres da gestação e o peso ao nascer foi avaliado como variável contínua e como variável dicotômica: baixo peso ao nascer (<2.500,00 g) e peso normal (> 2.500,00 g). A relação entre Hb e peso ao nascer foi avaliada por meio de regressão linear múltipla. Curvas ROC foram utilizadas para identificar pontos de corte para Hb com melhor sensibilidade e especificidade para baixo peso ao nascer. Resultados: Nos modelos explicativos para o peso ao nascer, verificou-se que as concentrações de Hb foram negativamente associadas ao peso ao nascer nos três trimestres da gravidez (1º trimestre: β = -45,02, IC 95% -75,18 a -14,86; 2º trimestre: β = -45,02, IC 87;11,46), controlando para idade gestacional no parto, ganho de peso gestacional, número de partos anteriores e pré-IMC gestacional. O peso médio ao nascer foi significativamente maior entre as mulheres nos quartis inferiores de Hb no primeiro (p = 0,012) e no terceiro (p = 0,002) trimestres. Os valores de Hb relacionados ao baixo peso ao nascer no 1º, 2º e 3º trimestres foram 12,6 g / dL, 11,4 g / dL e 12,35 g / dL, respectivamente. Conclusão: Os resultados sugerem uma associação inversa entre maiores concentrações de Hb e menor peso ao nascer.

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Section: Discussionmentioning

confidence: 99%

A relação entre as concentrações de hemoglobina durante a gravidez e peso de nascimento / The relationship between hemoglobin concentrations during pregnancy and birth weight

Santana¹,

Barbosa²,

Carmo³

et al. 2021

BJDV

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“…The value of maternal serum ferritin in predicting asymmetric IUGR was previously investigated, for few times, on small numbers of cases, i.e. 7 cases in Ozgu-Erdinc et al [9] , 18 cases in Milasinovic et al [13] , 10 cases in Hubel et al [14] , 17 cases in Visnjevac et al [15] , and 31 cases in Bindal et al, [16] or with limitations in the research methodology such as measuring ferritin at a gestational age that was to early (20 weeks) or to late (36 weeks) [1,4] , or including cases with maternal iron deficiency anemia [15] .…”

Section: Discussionmentioning

confidence: 99%

“…[22] Hou et al, Milasinovic et al and Višnjevac et al identified the ferritin threshold to predict IUGR or SGA as >13.6 ng/ml. [4,13,15] Ozgu et al reported maternal serum ferritin levels >60 ng/ml to increase the risk for IUGR. [9] Bindal et al concluded that maternal serum ferritin >20 ng/ml predicted IUGR with an odds ratio of 6.6.…”

Section: Discussionmentioning

confidence: 99%

“…[11] Ferritin blood level normally drops, in correlation with the progressive depletion of iron reserves, by 32% during the first trimester, 39% in the second and up to 53% during the third trimester. [12] This level reaches a nadir at 30-32 weeks, [13] after which it stays constant.…”

Section: Introductionmentioning

confidence: 99%

“…IUGR relies on decreased placental extraction of ferritin from the systemic circulation. [13] Its predictive value was previously investigated, in a few small-sized studies, on a small number of cases. [9,[13][14][15][16] This study aimed to assess the accuracy of maternal serum ferritin level at 30 weeks to 32 weeks in predicting the development of IUGR and to identify the ferritin cutoff level with the best predictive value, in a well-selected, adequate-sized group of pregnant women.…”

Section: Introductionmentioning

confidence: 99%

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Role of Maternal Serum Ferritin in the Prediction of Asymmetric Intrauterine Growth Restriction

Salem

Ashoush

Bayoumi

et al. 2019

Evidence Based Women's Health Journal

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Aim: Asymmetric intrauterine growth restriction (IUGR) carries increased intrauterine and neonatal risks. Since most cases are idiopathic, identifying a predictive test remains an ideal prevention management. Maternal serum ferritin level is a potential predictor of later developing asymmetric IUGR. Patients and Methods: Blood samples were drawn, at 30-32 gestational weeks, from 450 women who were then followedup resulting in 32 term pregnancies with asymmetric IUGR. The control group included the first recruited 32 women delivering adequate for gestational age neonates at term. Serum ferritin was then measured in the stored serum samples. Ultrasound scanning was performed at 30-32 weeks then at 37 weeks. Umbilical and middle cerebral artery Doppler scans were added at 37 weeks. Results: Serum ferritin, at 30-32 weeks, was higher in women delivering IUGR babies (19.3±6.83 vs 14±5.18, p<0.01). At 37 weeks, pregnancies with asymmetric IUGR had significantly (p<0.01) higher umbilical artery resistance and pulsatility indices (0.71±0.06 vs 0.59±0.07 and 1.24±0.17 vs 0.86±0.09, respectively). Their middle cerebral artery RI and PI were significantly (p<0.01) lower than controls (0.74±0.09 vs 0.81±0.05 and 1.64±0.07 vs 1.9±0.15, respectively). Ferritin level correlated significantly with neonatal birthweight. A cutoff level >18.2 ng/mL had a sensitivity of 59.4% and a specificity of 90.6%. The area under curve showed an accuracy of 76.8%. Women with ferritin >18.2 ng/ml were 10.23 times more likely to get asymmetrically growth restricted neonates (CI 2.89-36.17, p<0.001). Conclusion: This study presents further evidence that maternal serum ferritin may be a useful test in the prediction of asymmetric IUGR.

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Study of Role of Maternal Serum Ferritin in the Prediction of Asymmetric Intrauterine Growth Restriction

Elfayomy¹,

Abdelsalam²,

Mohamed³

et al. 2023

The Egyptian Journal of Hospital Medicine

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Background: Late-onset asymmetric Intrauterine Growth Restriction (IUGR) is associated with an increase in the maternal serum ferritin level, which is thought to be caused by a decrease in placental extraction ferritin from the systemic circulation. Objective: The aim of the current study was to predict asymmetric IUGR by measuring maternal serum ferritin at 30-32 weeks of gestation. Patients and methods: A cross sectional study was conducted on a total of 550 women. At 30-32 weeks of gestation, maternal serum ferritins were assessed. Of the studied women, 84 women were selected and divided into two groups; 42 cases of elevated serum ferritin level taken as a case group and the first included 42 cases with normal serum ferritin level served as a control group. At 30-32 weeks of gestation, we assessed maternal serum ferritin. Results: Serum ferritin is good marker for detecting cases of IUGR at cut off ≥12.45 with a sensitivity of 85.7%, a specificity of 35.7%, a positive predictive value of 57.1% and a negative predictive value of 71.4%., while serum ferritin is good marker for excluding cases of IUGR at cut off ≥20.5 with a sensitivity of 33.3%, a specificity of 85.7%, a positive predictive value of 70% and a negative predictive value of 56.3%. Conclusion: Serum ferritin level with a cut off level ≥12.45 ng/dl in addition to ultrasonography has as a predictive value of asymmetric IUGR

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Significance of serum ferritin level in the prediction of delivery of low birth weight newborns for gestational age

Abstract: Based on the level of ferritin and other parameters in the period of 30-32 weeks of gestation, we can predict pregnant women in whom we can expect development of intrauterine growth restriction.

Cited by 3 publications

References 11 publications

A relação entre as concentrações de hemoglobina durante a gravidez e peso de nascimento / The relationship between hemoglobin concentrations during pregnancy and birth weight

A relação entre as concentrações de hemoglobina durante a gravidez e peso de nascimento / The relationship between hemoglobin concentrations during pregnancy and birth weight

Role of Maternal Serum Ferritin in the Prediction of Asymmetric Intrauterine Growth Restriction

Study of Role of Maternal Serum Ferritin in the Prediction of Asymmetric Intrauterine Growth Restriction

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