Significance of serum glucocorticoid and chelatable zinc in depression and cognition in zinc deficiency

Takeda, Atsüshi; Tamano, Haruna; Ogawa, Taisuke; Takada, S.; Ando, Masaki; Oku, Naoto; Watanabe, Mamoru

doi:10.1016/j.bbr.2011.09.026

Cited by 50 publications

(26 citation statements)

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“…Extracellular glutamate accumulation in the hippocampus is potentiated by glucocorticoids [59], the main hormones of the hypothalamic-pituitary-adrenal (HPA) axis. It is thought that zinc deficiency can cause alterations of the HPA axis in depression [30,60,66,68]. During zinc deficiency, chronic alteration of corticosterone secretion and a decrease in synaptic zinc levels seems to be linked to the excitability of glutamatergic neurons in the hippocampus [58,60].…”

Section: Zinc Deficiency Alters Responsiveness To Antidepressantsmentioning

confidence: 99%

“…It has been reported recently that zinc deficiency induced by a zinc-deficient diet evokes behavioral disturbances in animals, e.g., enhanced depression-like behavior was found after dietary zinc deprivation in the tail suspension test (TST) [31,69] and the forced swim test (FST) [30,63,64,68,69] and was reversed by desipramine [69] while administration of fluoxetine did not reduce behavioral despair caused by zinc deprivation [64]. Some authors correlate zinc deficient-induced depression-like behavior with hyperactivation of the hypothalamicpituitary-adrenal (HPA) axis [30,60,68]. This may in turn be linked to the dyshomeostasis of glutamatergic system.…”

Section: Introductionmentioning

confidence: 99%

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Zinc deficiency alters responsiveness to antidepressant drugs in mice

Młyniec

Budziszewska

Reczyński

et al. 2013

Pharmacological Reports

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Abstract:Background: There is some evidence coming from preclinical and clinical studies suggesting a relationship between dietary zinc intake and depressive symptoms. The aim of the study was to determine whether zinc deficiency alters the response to antidepressants with a different mechanism of action. We examine also whether these changes are related to activity of the hypothalamic-pituitaryadrenal HPA axis. Methods: Male CD-1 mice were assigned to groups according to diet and antidepressant administration. To evaluate animal behavior, the immobility time in the forced swim test (FST) and locomotor activity were measured. To determine serum zinc levels the flame atomic absorption spectroscopy (FAAS) was used. The serum corticosterone was determined by radioimmunoassay (RIA). Results: Antidepressants administered to zinc-deprived mice induced an altered response in the FST when compared to animals fed with an adequate diet. There were no changes in locomotor activity. Animals subjected to a zinc-deficient diet showed a significant reduction in serum zinc levels, which was normalized by antidepressant treatment. An increase in serum corticosterone concentrations in mice fed with a zinc-deficient diet and treated with antidepressants was observed, so it can be concluded that reduced levels of zinc contribute hyperactivation of the HPA axis. Conclusion:The results of this study suggest that a diet with a reduced zinc level alters antidepressant action, which is associated with a reduction in the serum zinc level and rise in the corticosterone level. The results of this study may indicate the involvement of zinc deficiency in the pathogenesis of depression.

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Section: Zinc Deficiency Alters Responsiveness To Antidepressantsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Zinc deficiency alters responsiveness to antidepressant drugs in mice

Młyniec

Budziszewska

Reczyński

et al. 2013

Pharmacological Reports

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“…Zinc is a trace element important for neurogenesis, neuronal growth, synaptogenesis, and neurotransmission [6]. A deficiency of zinc may not only lead in poor cognitive performance, but also cause some alteration in attention, activity, neuropsychological behavior and motor development [16,17]. A class of glutaminergic neurons store zinc in specific synaptic vesicles which is released as a neuro-modulator in an activity-dependent manner [18].…”

Section: Discussionmentioning

confidence: 99%

“…The roles of zinc in central nervous system include: a, the involvement of zinc -dependent enzymes in brain growth; b, the participation of zincfinger proteins in brain structure and neurotransmission; c, the involvement of zinc -dependent neurotransmitters in brain memory function; d, the involvement of zinc in the precursor production of neurotransmitters; e, the role of metallothionein-III as a protein that binds zinc in neurons [20]. It is also responsible for the movement of zinc from the cytoplasm into synaptic vesicles [16]. Children with ADHD (attention deficit hyperactivity disorder) have been shown to have lower levels of zinc and copper in both hair and serum as compared to the normal children in control groups [21] so zinc deficiency has an important role in the pathogenesis of ADHD [22].…”

Section: Discussionmentioning

confidence: 99%

A Research on the Level of Zinc and Copper in the Hair of Students with Lower IQ

Meghrazi

Sabet²,

Kheradmand

et al. 2017

Zahedan J Res Med Sci

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Background: The measurement of trace elements in human body has proved to be of great use in the evaluation of human health and the diagnosis of various diseases. No light, however, has been shed on these elements where they concern the human intelligence. Objectives:The goal is to make a comparison between the students with a lower IQ and those having an ordinary IQ in terms of the amount of zinc and copper as two trace elements. Methods: This is a case-control study and the subjects as the patients were chosen from mentally retarded students having no particular diseases. The sample size for the patient and control was 30 for each. The hair samples of the experimental group and the ordinary students (the control group) were digested with concentrated HNO3 after being washed with water and acetone. After being digested, the values of zinc and copper in the samples were measured with atomic absorption spectroscopy. The obtained data were analyzed using SPSS-15 via two independent sample tests of significance tests.

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“…Zinc deficiency can also cause neuropsychological and cognitive disorders [26]. Also the relation of zinc with Alzheimer's disease and other neurodegenerative diseases has been confirmed.…”

Section: Effects Of Zinc Deficiencymentioning

confidence: 93%

The Biomedical Role of Zinc in the Functioning of the Human Organism

Białek

Zyska

2014

Polish Journal of Public Health

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Zinc is one of the most important microelements that can be found in the human organism. It is a component or an activator of various enzymes and takes part in more than 300 enzymatic reactions. It is present in all types of human tissue. About 90% of the general amount of zinc can be found in bones and muscles, 11% in liver and skin. Zn 2+ ions are stable ions in biological environment and they do not participate in redox reactions that occur inside an organism. Assimilability of this element by living organisms is varied. It depends largely on the sort of food and interactions occurring between zinc and other elements. Zinc is an essential element for normal development and maintenance of human health.The data presented in this article result from an overview of studies presented in literature published in the last five years concerning zinc transport mechanisms, the role of zinc in functioning of the human body, and also pathophysiological states caused by too low or excessive concentration of zinc in an organism.Chair of Public Health of the Technical University in Częstochowa, Poland Keywords: trace elements, zinc, functioning of the human organism.Activity of this bio element can be observed among others in such processes as mineralisation of bones, healing of injuries, correct secretion of insulin by pancreas, or maintaining the right level of vitamin A and cholesterol. The significant role of zinc was also observed in immunological processes. Moreover, zinc regulates blood pressure and pulse, contributes to the raised production of sperm, has a healing effect on the stomach-intestinal system, varicose veins, rheumatism and skin diseases [6]. Zinc deficiency, observed within human population in developing countries, triggers many disorders in functioning of the whole systems, as well as individual human organs [7]. Zinc is relatively little toxic for health, but its excess causes health disorders, such as vomiting, weakness, anaemia [5].Information presented in the article results from the review of studies presented in the literature in the last five years, concerning transport mechanisms of zinc, the role of zinc in body`s metabolism, and also pathophysiological states caused by too low or excessive concentration of zinc in an organism.

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Significance of serum glucocorticoid and chelatable zinc in depression and cognition in zinc deficiency

Cited by 50 publications

References 50 publications

Zinc deficiency alters responsiveness to antidepressant drugs in mice

Zinc deficiency alters responsiveness to antidepressant drugs in mice

A Research on the Level of Zinc and Copper in the Hair of Students with Lower IQ

The Biomedical Role of Zinc in the Functioning of the Human Organism

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