Significance of serum interleukin‐8 levels in patients with Behcet's disease: high levels may indicate vascular involvement

Durmazlar, Selda Pelin Kartal; Ülkar, Gül Bahar; Eskioğlu, Fatma; Tatlıcan, Semih; Mert, Ali; Akgül, Ahmet

doi:10.1111/j.1365-4632.2009.03905.x

Cited by 62 publications

(34 citation statements)

References 29 publications

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“…These results are in agreement with previous work, which report similar increases in ESR and CRP levels in BD patients 5,6 . Superoxide release was significantly increased in BD patients compared to controls, both at basal conditions and in response to 10 µM fMLP stimulation (Figure 2A).…”

Section: Discussionsupporting

confidence: 94%

“…Once secreted, IL-1 and TNF-α activate vascular endothelium, leading to increased expression of E-selectin and P-selectin in BD 4 , which function as receptors for leukocyte adhesive proteins. IL-1, TNF-α, and IL-6 also activate hepatocytes to synthesize acute-phase proteins, which are also elevated in BD patients 5,6 . The activation state of neutrophils in BD patients is also evident by the expression of several surface antigens and levels of circulating proteins released by neutrophils.…”

Section: Introductionmentioning

confidence: 99%

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Oxidases and oxygenases in regulation of neutrophil redox pathways in Behçet’s disease patients

Melikoğlu

Kaçar

Çört

et al. 2011

Journal of Enzyme Inhibition and Medicinal Chemistry

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Section: Discussionsupporting

confidence: 94%

Section: Introductionmentioning

confidence: 99%

Oxidases and oxygenases in regulation of neutrophil redox pathways in Behçet’s disease patients

Melikoğlu

Kaçar

Çört

et al. 2011

Journal of Enzyme Inhibition and Medicinal Chemistry

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“…Autoantibodies, binding molecules exposed on the surface of neurons, lead to a neurotoxic effect [1,30]. Increased levels of TNF, IL-6 [31], IL-18 [32] and IL-8 have been reported in cultures of monocytes from people with BD [33,34]. IL-8 in particular attracts and activates neutrophils and other leukocytes and is thought to mediate endothelial damage in BD.…”

Section: Discussionmentioning

confidence: 99%

The role of infections in Behçet disease and neuro-Behçet syndrome

Marta¹,

Santos²,

Coutinho³

et al. 2015

Autoimmunity Reviews

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Infections are considered an environmental trigger for exacerbations of immune-mediated diseases. We aimed to establish if common viral infections could be identified as a precipitant of Behçet disease (BD) with or without neurological involvement and to assess the variability of the immune response to common viruses. We also investigated whether cytokines and chemokines could be markers of neurological involvement. Finally, we explored if anti-basal ganglia antibodies (ABGAs) would be associated with neurological involvement in BD. Our study included 14 individuals with BD with neurological involvement (neuroBehçet syndrome - NBS), 16 individuals with BD without neurological involvement and 18 healthy controls (HC). Overall we found a tendency for increased levels of anti-viral IgG antibody levels in BD, more evident in NBS patients versus HC. Epstein-Barr viral-capsid antigen IgG titres were increased in NBS patients versus other BD patients (p=0.032). Anti-measles antibody titres induced by vaccination were similarly elevated. ABGAs were not detected in the serum of our cohort. Raised levels of serum IL-8 in some BD patients did not reflect clinical activity or severity. In conclusion, there was evidence for a polyclonal immune activation rather than a specific virus effect in the sera of individuals with BD or NBS.

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“…Recently, Ambrose et al demonstrated significantly higher production of CXCL10/IP10 in blood monocytes of BD patients stimulated with IFNγ compared to HC, rheumatoid arthritis, and systemic lupus erythematosus controls [170]. There is even more robust evidence for CXCL8/IL8, a potent neutrophil chemoattractant, being implicated in BD pathogenesis, with some of the authors proposing that it could be a marker for vascular involvement and a more reliable marker for disease activity than the C-reactive protein or erythrocyte sedimentation rate [171][172][173][174].…”

Section: Chemokinesmentioning

confidence: 99%

Etiology, Immunopathogenesis and Biomarkers in Behçet’s disease

Adeeb¹,

Khan²,

Stack³

et al. 2017

Behcet's Disease

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Behçet's disease (BD) is a type of vasculitis with many distinctive clinical manifestations and multifactorial immunopathogenesis. The cause of BD remains unknown, but it has been postulated that in a genetically predisposed or susceptible population, exogenous agents trigger the dysregulation of both autoinflammatory and autoimmune responses resulting in multisystem vasculitis. There are robust ongoing efforts across the globe to elucidate and identify signature markers to improve and assist in rapid diagnosis of the disease and to tailor the best therapy accordingly. While association of human leukocyte antigen (HLA)-B * 51 (B * 51:01 subtype) allele is well recognized as the strongest genetic susceptibility gene so far among genetically predisposed BD patients, further investigations using the latest technology have led to the identification of several novel single nucleotide polymorphisms (SNPs) and other associated genes involved in the pathogenesis. There are several "established" cytokines known to be involved in the pathogenesis of BD, which have been further implicated in the genome-wide association studies (GWAS)-based cytokine/receptor gene loci studies, as well as numerous "novel" cytokines, which are currently being studied and identified. This chapter offers insights into current knowledge and thoughts regarding the future of biomarkers in BD.

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Significance of serum interleukin‐8 levels in patients with Behcet's disease: high levels may indicate vascular involvement

Abstract: Serum IL-8 levels are increased in the active phase of BD. This marker may be useful in the early detection of vascular involvement.

Cited by 62 publications

References 29 publications

Oxidases and oxygenases in regulation of neutrophil redox pathways in Behçet’s disease patients

Oxidases and oxygenases in regulation of neutrophil redox pathways in Behçet’s disease patients

The role of infections in Behçet disease and neuro-Behçet syndrome

Etiology, Immunopathogenesis and Biomarkers in Behçet’s disease

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