Significance of serum neurokinin B and kisspeptin levels in the differential diagnosis of premature thelarche and idiopathic central precocious puberty

Abacı, Ayhan; Çatlı, Gönül; Anık, Ahmet; Küme, Tuncay; Çalan, Özlem Gürsoy; Dündar, Bumin Nuri; Böber, Ece

doi:10.1016/j.peptides.2014.12.011

Cited by 24 publications

(32 citation statements)

References 38 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In this study, Abacı et al (8) reported that neurokinin B is significantly higher in ICPP and PT groups than in age-matched prepubertal controls, while there is no difference between the ICPP and PT groups. The limited number of subjects (22 girls with ICPP and 20 with PT) was reported as the limitation of the study.…”

Section: Discussionmentioning

confidence: 41%

“…Kisspeptin is the most extensively studied neuropeptide in puberty and precocious puberty (6,7,8). In human, KISS1 is located on chromosome 1q32 and is detected in brain, pancreas, placenta, testis and genital tract (10).…”

Section: Discussionmentioning

confidence: 99%

“…After 6 months of treatment with GnRHa, kisspeptin level was lower than that prior to treatment. In another study, Abacı et al (8) evaluated serum kisspeptin levels in girls with ICPP and PT compared to healthy prepubertal girls. They detected higher serum kisspeptin levels in ICPP and PT groups than in controls, but there was no significant difference in serum kisspeptin levels between ICPP and PT groups.…”

Section: Discussionmentioning

confidence: 99%

“…To our knowledge, there is only one reported study evaluating the serum neurokinin B levels in girls with ICPP and PT compared to prepubertal controls (8). In this study, Abacı et al (8) reported that neurokinin B is significantly higher in ICPP and PT groups than in age-matched prepubertal controls, while there is no difference between the ICPP and PT groups.…”

Section: Discussionmentioning

confidence: 99%

“…Therefore, there is a need for a simple method for the differential diagnosis. To date, numerous studies have been published on kisspeptin and/or neurokinin B levels in girls with CPP (6,7,8). In these studies, it has been demonstrated that basal serum kisspeptin and/or neurokinin B levels are higher in girls with CPP and PT as compared to healthy controls.…”

Section: Introductionmentioning

confidence: 99%

See 4 more Smart Citations

Basal Serum Neurokinin B Levels in Differentiating Idiopathic Central Precocious Puberty from Premature Thelarche

Parlak¹,

Türkkahraman²,

Elli̇dağ³

et al. 2017

Jcrpe

View full text Add to dashboard Cite

Objective:To find out the diagnostic role of kisspeptin and neurokinin B in idiopathic central precocious puberty (ICPP) and premature thelarche (PT).Methods:The girls who presented with early breast development before the age of 8 years were evaluated. Patients with intracranial pathologies were excluded. Basal and stimulated follicle-stimulating hormone/luteinizing hormone (LH) levels and basal neurokinin B/kisspeptin levels were measured. Patients who had peak value of LH >5 mIU/mL and a bone age (BA)/chronological age (CA) ratio >1.1 were diagnosed as central precocious puberty (CPP), while cases who did not meet these criteria were diagnosed as PT. Healthy age-matched prepubertal girls were included as the control group.Results:The study group contained 25 girls with ICPP (7±0.8 years), 35 girls with PT (6.8±0.7 years), and 30 controls (6.7±0.7 years). Basal serum kisspeptin and neurokinin B levels were 2.36±0.47 ng/mL and 2.61±0.32 ng/mL, respectively in the ICPP group, 2.23±0.43 ng/mL and 2.24±0.23 ng/mL, respectively in the PT group, and 1.92±0.33 ng/mL and 2.03±0.24 ng/mL, respectively in the controls. Both kisspeptin and neurokinin B levels were higher in the ICPP and PT groups compared to controls (p<0.05). Moreover, basal neurokinin B level was different between ICPP and PT groups (p<0.01). A serum neurokinin B level of 2.42 ng/mL provided the most appropriate level to differentiate ICPP from PT, with a sensitivity of 84% and specificity of 77.1%.Conclusion:Differentiation of CPP from PT is sometime difficult, and there is a need for a simple method for the differential diagnosis. Our results suggest that basal serum neurokinin B level can be used as an adjunctive parameter to differentiate ICCP from PT.

show abstract

Section: Discussionmentioning

confidence: 41%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

Basal Serum Neurokinin B Levels in Differentiating Idiopathic Central Precocious Puberty from Premature Thelarche

Parlak¹,

Türkkahraman²,

Elli̇dağ³

et al. 2017

Jcrpe

View full text Add to dashboard Cite

show abstract

Kisspeptin Role in Functional Hypothalamic Amenorrhea

Podfigurna

Czyźyk

Szeliga

et al. 2019

Menstrual Cycle Related Disorders

View full text Add to dashboard Cite

The LIFE PERSUADED project approach on phthalates and bisphenol A biomonitoring in Italian mother-child pairs linking exposure and juvenile diseases

Rocca

Maranghi

Tait

et al. 2018

Environ Sci Pollut Res

View full text Add to dashboard Cite

Phthalates and bisphenol A (BPA), plasticizers used in several products of daily life, are considered as endocrine disrupters, therefore children exposure is particularly relevant. The LIFE PERSUADED project aims to define the following: (a) the evaluation of internal levels of DEHP’s metabolites and BPA in Italian children and their mothers, (b) the association of the exposure with puberty development and obesity diseases, and (c) the effects of exposure in juvenile in vivo model. The cross-sectional study has involved 2160 mother-child pairs, including males and females, children and adolescents, from urban and rural areas of North, Center, and South Italy. A structured questionnaire and a food diary are designed to evaluate the association between lifestyle variables potentially related to DEHP/BPA exposure and internal levels, through univariate and multivariate analyses. Two pilot case-control studies are carried out on idiopathic premature thelarche and precocious puberty (30 girls each group, aged 2–7 years) and idiopathic obesity (30 boys and 30 girls, aged 6–10 years), matched to healthy controls. BPA and DEHP’s metabolites are analyzed in urine samples from all recruited subjects. Clinical and toxicological biomarkers are evaluated in serum of case-control subjects. Moreover, the toxicity study is carried out in a juvenile rodent model exposed to mixtures of BPA and DEHP at dose levels recorded in children population. The scientific results of LIFE PERSUADED will contribute to risk assessment of BPA and DEHP.

show abstract

Significance of serum neurokinin B and kisspeptin levels in the differential diagnosis of premature thelarche and idiopathic central precocious puberty

Cited by 24 publications

References 38 publications

Basal Serum Neurokinin B Levels in Differentiating Idiopathic Central Precocious Puberty from Premature Thelarche

Basal Serum Neurokinin B Levels in Differentiating Idiopathic Central Precocious Puberty from Premature Thelarche

Kisspeptin Role in Functional Hypothalamic Amenorrhea

The LIFE PERSUADED project approach on phthalates and bisphenol A biomonitoring in Italian mother-child pairs linking exposure and juvenile diseases

Contact Info

Product

Resources

About