Significance of serum tumor markers monitoring in carcinomas of unknown primary site

Pejčić, Ivica; Vrbić, Svetislav; Filipovic, Sladjana; Scekic, Mirjana; Petković, Ivan; Pejcic, Ljiljana; Djenic, Nebojsa

doi:10.2298/vsp1009723p

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Hormonal Pathways1

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2012

2013

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Cited by 2 publications

(2 citation statements)

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“…The serum levels of NSE showed good correlation with response to the chemotherapy (Pejcić et al, 2010).…”

Section: Discussionmentioning

confidence: 79%

For Which Cancer Types can Neuron-Specific Enolase be Clinically Helpful in Turkish Patients?

Bilgin

Dizdar²,

Serilmez³

et al. 2013

Asian Pacific Journal of Cancer Prevention

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“…The serum levels of NSE showed good correlation with response to the chemotherapy (Pejcić et al, 2010).…”

Section: Discussionmentioning

confidence: 79%

For Which Cancer Types can Neuron-Specific Enolase be Clinically Helpful in Turkish Patients?

Bilgin

Dizdar²,

Serilmez³

et al. 2013

Asian Pacific Journal of Cancer Prevention

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“…Recently, beta-hCG and alpha-fetoprotein have been detected in OVC germ cell tumors [88,89]. These proteins have been detected at early stages of the cancer, as well as lysophosphatidic acid, mesothelin, HE4, osteopontin, VEGF, IL-8, M-CSF, different kallikreins [90][91][92], and the Cterminal fragment of the 11S immunoproteasome (Reg-alpha) [1,67]. Most of the above proteins are directly linked to signaling pathways for cytoskeleton remodeling, contractility, junction remodeling, adhesion, invasion, migration, cell cycle progression, proliferation, metastasis, apoptosis/necrosis, angiogenesis, endothelial permeability, vascular remodeling, metalloprotease activation, and EGFR transactivation (Fig.…”

Section: Hormonal Pathwaysmentioning

confidence: 99%

Ovarian cancer molecular pathology

Longuespée

Boyon

Desmons

et al. 2012

Cancer Metastasis Rev

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Ovarian cancer (OVC) is the fourth leading cause of cancer mortality among women in Europe and the United States. Its early detection is difficult due to the lack of specificity of clinical symptoms. Unfortunately, late diagnosis is a major contributor to the poor survival rates for OVC, which can be attributed to the lack of specific sets of markers. Aside from patients sharing a strong family history of ovarian and breast cancer, including the BRCA1 and BRCA2 tumor suppressor genes mutations, the most used biomarker is the Cancer-antigen 125 (CA-125). CA-125 has a sensitivity of 80 % and a specificity of 97 % in epithelial cancer (stage III or IV). However, its sensitivity is 30 % in stage I cancer, as its increase is linked to several physiological phenomena and benign situations. CA-125 is particularly useful for at-risk population diagnosis and to assess response to treatment. It is clear that alone, CA-125 is inadequate as a biomarker for OVC diagnosis. There is an unmet need to identify additional biomarkers. Novel and more sensitive proteomic strategies such as MALDI mass spectrometry imaging studies are well suited to identify better markers for both diagnosis and prognosis. In the present review, we will focus on such proteomic strategies in regards to OVC signaling pathways, OVC development and escape from the immune response.

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Significance of serum tumor markers monitoring in carcinomas of unknown primary site

Cited by 2 publications

References 16 publications

For Which Cancer Types can Neuron-Specific Enolase be Clinically Helpful in Turkish Patients?

For Which Cancer Types can Neuron-Specific Enolase be Clinically Helpful in Turkish Patients?

Ovarian cancer molecular pathology

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