Significance of Serum Uric Acid in Pregnancy Induced Hypertension

Niraula, Apeksha; Lamsal, Madhab; Majhi, S; Khan, Seraj Ahmed; Basnet, Pritha

doi:10.1016/j.jnma.2017.01.009

Cited by 13 publications

(16 citation statements)

References 20 publications

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“…Hyperuricemia occurs as a consequence of reduced 26 . A study conducted by Niraula A 2017 27 , found increased mean uric acid levels in gestational hypertension as compared to control group. In another study, uric acid concentrations in second trimester were observed as a good predictor for the pre-eclampsia at a cut-off value of 7.35 mg/dl 28 , which are consisted with our findings that found mean concentration of serum uric acid to be 7.35±1.85 mg/ dl.…”

Section: Results Are Presented As N (%) Chi-square Test Appliedmentioning

confidence: 94%

Assessment of Serum Lipid and Uric Acid Levels in Women with Normal Pregnancy and Pre-Eclampsia

2019

J Liaquat Uni Med Health Sci

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Section: Results Are Presented As N (%) Chi-square Test Appliedmentioning

confidence: 94%

Assessment of Serum Lipid and Uric Acid Levels in Women with Normal Pregnancy and Pre-Eclampsia

2019

J Liaquat Uni Med Health Sci

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“…These two indicators could be used as markers for the diagnosis of PIH. A study showed that ( 18 ) PIH patients had significantly higher mALb level than pregnant women without PIH, and elevated mALb excretion proceeded other clinical manifestations. Another study by Ertas et al ( 19 ) showed that e treatment of PIH patients.…”

Section: Discussionmentioning

confidence: 99%

Evaluation of the predictive value of high sensitivity C-reactive protein in pregnancy-induced hypertension�syndrome

et al. 2018

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Relationship between serum high sensitive C-reactive protein (hs-CRP) and pregnancy-induced hypertension syndrome (PIH) was investigated. One hundred and twenty patients with PIH treated in the First People's Hospital of Chengdu (60 cases of mild preeclampsia, 60 cases of severe preeclampsia) were enrolled in the study. The control group included 60 women with normal singleton pregnancy. Serum hs-CRP and microalbuminuria (mALB) levels were measured by an AU5800 automatic biochemical analyzer (Beckerman Coulter), and the risk factors were analyzed by ROC curve analysis. Patients with PIH had higher levels of serum hs-CRP and mALB than the control group (P<0.01). Serum hs-CRP and mALB levels in the severe preeclampsia group were significantly higher than those in the mild preeclampsia group (P<0.05). ROC curve analysis showed that hs-CRP was a factor of high-risk. Area under the curve was 0.943, and the 95% confidence interval was 0.848–0.974. Detection of serum hs-CRP in patients with PIH can provide references for the prediction of the severity of the disease, and higher level of hs-CRP indicates worse condition.

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“…Uric acid as a predictor for severity in PIH shows that serum uric acid was significantly higher in the PIH group than the normotensive group (5.46 ± 1.51 vs. 4.03 ± 0.69, p = 0.001). Receptor Operating Characteristics curve (ROC) curve was drawn to determine the diagnostic utility of serum uric acid, and a Sensitivity/Specificity of 79.07% 71.19% were reported with AUC = 0.805. thus, this study concluded that uric acid assessment is a convenient and efficient method for early prediction of PIH [38]. Microalbuminuria at mid-pregnancy using the Albumin and creatinine ratio (ACR) as a predictor of pre-eclampsia between 24-28 GA was evaluated, and ACR between 30 and 299 mg/g creatinine was considered as Microalbuminuria.…”

Section: Screening and Diagnosismentioning

confidence: 99%

“…This finding is similar to a report by Zen et al 2019 [63], that a high level of uACR in the third trimester was associated with the development of pre-eclampsia (p = 0.01) and Rodriguez et al 1998 [64], which reported that 83% of patients with microalbuminuria level �11 μg/ml and calcium/creatinine ratio �0.04 developed preeclampsia whereas 94% of women with optimum microalbuminuria and calcium/creatinine ratio did not. Serum Uric Acid is also a convenient and efficient method for early prediction of PIH with a reported sensitivity and specificity of 79% and 71%, respectively [38]. Investigation of sTWEAK and its prognostic ability in high-risk pregnancy revealed that sTWEAK subsequently reduced from 4.03±0.37 ng/dl at baseline to 1.93±0.23 mg/dl at follow up and is significantly lower when compared to normotensive high-risk and negative control group (p<0.001).…”

Section: Plos Onementioning

confidence: 99%

Generating evidence on screening, diagnosis and management of non-communicable diseases during pregnancy; a scoping review of current gap and practice in India with a comparison of Asian context

et al. 2021

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Background Children born to high-risk pregnancies are more likely to experience adverse health outcomes later in life. As estimated, 15% of all pregnancies are at risk of various life-threatening conditions leading to adverse maternal and foetal outcomes. Millennium Development Goal resulted in the global reduction of maternal death from 390,000 to 275000 in 1990–2015). Similarly, to keep this momentum, the current United Nations Sustainable Development Goal (SDG: 3.1) aims at reducing the global maternal mortality ratio to less than 70 per 100,000 live births by 2030, and this can be achieved by addressing high-risk pregnancy contributing to significant mortality and morbidity. In India, gestational diabetes, gestational hypertension, and gestational hypothyroidism were identified as factors contributing to the high-risk pregnancy. This review summarises the commonly used approach for screening, diagnosis, and management of these conditions in the Asian population. It draws a comparison with the current protocols and guidelines in the Indian setting. Methods Electronic search in PubMed and Google Scholar, reference snowballing, and review of current guidelines and protocols were done between January 2010 to October 2019. Published studies reporting Screening, diagnosis, and management of these conditions were included. Articles selected were then screened, appraised for quality, extract relevant data, and synthesised. Results Screening, diagnosis, and management of these three conditions vary and no single universally accepted criteria for diagnosis and management exist to date. In India, national guidelines available have not been evaluated for feasibility of implementation at the community level. There are no national guidelines for PIH diagnosis and management despite the increasing burden and contribution to maternal and perinatal morbidity and mortality. Criteria for diagnosis and management of gestational diabetes, gestational hypertension, and gestational hypothyroidism varies but overall early screening for predicting risk, as reported from majority of the articles, were effective in minimizing maternal and foetal outcome. Conclusion Existing National guidelines for Screening, Diagnosis, and Management of Gestational Diabetes Mellitus (2018) and Gestational Hypothyroidism (2014) need to be contextualized and modified based on the need of the local population for effective treatment. Findings from this review show that early screening for predicting risk to be an effective preventive strategy. However, reports related to a definitive diagnosis and medical management were heterogeneous.

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Significance of Serum Uric Acid in Pregnancy Induced Hypertension

Cited by 13 publications

References 20 publications

Assessment of Serum Lipid and Uric Acid Levels in Women with Normal Pregnancy and Pre-Eclampsia

Assessment of Serum Lipid and Uric Acid Levels in Women with Normal Pregnancy and Pre-Eclampsia

Evaluation of the predictive value of high sensitivity C-reactive protein in pregnancy-induced hypertension�syndrome

Generating evidence on screening, diagnosis and management of non-communicable diseases during pregnancy; a scoping review of current gap and practice in India with a comparison of Asian context

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