Significance of sperm characteristics in the evaluation of male infertility

Nallella, Kiran P.; Sharma, Rakesh K.; Aziz, Nabil; Agarwal, Ashok

doi:10.1016/j.fertnstert.2005.08.024

Cited by 245 publications

(177 citation statements)

References 20 publications

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“…Moreover, there is little consensus as to which sperm characteristic is the best predictor of fertility [28]. Consequently, different associations of sperm parameters have been proposed to predict pregnancy and miscarriage [7,22,32,34]. We have found that conventional sperm parameters and apoptotic markers (membrane asymmetry loss, DNA denaturation and MMP) are related to natural conception and conception in IUI cycles, but not to IVF/ICSI conception.…”

Section: Discussionmentioning

confidence: 99%

Apoptotic sperm biomarkers and their correlation with conventional sperm parameters and male fertility potential

Zorn

Golob

Ihan

et al. 2012

J Assist Reprod Genet

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Purpose To investigate the relationship between sperm apoptotic biomarkers and patient clinical characteristics, conventional sperm parameters and fertility potential. Material and methods Sperm analysis, phospholipid asymmetry, mitochondrial membrane potential (MMP) and DNA denaturation were assessed in 142 males of infertile couples. Seventy-three couples were allocated to the natural conception group, and 55 couples underwent IVF or ICSI. Results DNA denaturation correlated positively with age and negatively with testicular volume (TV). MMP correlated negatively with BMI and FSH and positively with TV. Normal viable sperm correlated positively with TV and negatively with age, BMI and FSH. DNA denaturation was associated with a significantly lower natural pregnancy rate (OR 5.4, p00.011). Conclusion Sperm apoptosis is related to male age, BMI, testicular volume and FSH. Among the apoptotic markers, only DNA denaturation has been found to predict natural pregnancy better than conventional sperm parameters.

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Section: Discussionmentioning

confidence: 99%

Apoptotic sperm biomarkers and their correlation with conventional sperm parameters and male fertility potential

Zorn

Golob

Ihan

et al. 2012

J Assist Reprod Genet

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“…Sperm concentration, motility and morphology have been correlated with fertilization rates in vivo and in vitro [28]. Of these, several clinical studies have demonstrated a clear association between sperm head morphology and improvement in IVF success rate [29,30].…”

Section: Discussionmentioning

confidence: 99%

Sperm DNA Fragmentation is Significantly Increased in Those Men with Morphologically Abnormal Spermatozoa

Ferreyra¹

2014

JFIV Reprod Med Genet

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Purpose: To evaluate the levels of DNA fragmentation regarding to spermatozoa morphology in male infertility patients attending Andrology Laboratory at fertility center.Methods: Semen samples of 196 patients were analyzed using computer-assisted semen analysis (CASA). Sperm DNA fragmentation was measured by the sperm chromatin dispersion test. According to the values of sperm morphology, the groups were conformed by teratozoospermic (105 patients) and normozoospermic (91 patients) men.Results: Subjects' ages ranged from 21 to 68 years. Teratozoospermic men were older that the normozoospermic men (39.72 ± 7.86 vs. 36.57 ± 6.29 years; P<0.05). Values of pH were similar in both evaluated groups (P:NS). Parameters of volume, concentration, motility and vitality in teratozoospermic men were significantly lower compared to those normozoospermic patients (P<0.05). High levels of DNA fragmentation were observed in those patients with abnormal sperm morphology compared to normozoospermic men (44.31 ± 7.52 vs. 34.92 ± 5.89; P<0.05). Conclusions:Men with abnormal spermatozoa morphology showed high levels of DNA fragmentation. These significantly high percentages of sperm DNA damage will be an additional factor that drastically reduces the possibility of success in these infertile men.

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“…Progressive motility and non-progressive motility is reported as total motility. On one hand, some have considered sperm motility as one of the most powerful discriminators [Nallella et al 2006], while on the other hand, others have found this test to be of limited value [Bonde et al 1998]. …”

Section: Motilitymentioning

confidence: 99%

“…In comparison the Tygerberg strict criteria identifies normal sperm using a scaled measure for each single ellipseshaped head, the percentage of the head occupied by the acrosome, the width and length of the midpiece, the tail length and appearance, and the amount and location of cytoplasmic droplet/residual body. Opinion varies as to the efficacy of this measure as an effective predictor of fertility [Chia et al 1998;Guzick et al 2001;Nallella et al 2006].…”

Section: Morphologymentioning

confidence: 99%

Spermatozoa as biomarkers for the assessment of human male infertility and genotoxicity

Antón

Krawetz

2012

Systems Biology in Reproductive Medicine

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Establishing specific biomarkers for the assessment of human male fertility status is an important goal to ensure the fitness of the male contribution so as to support the birth of a healthy child. Spermatozoa are considered an optimal surrogate tissue for the evaluation of spermatogenic function. Unlike the cells of the testis, spermatozoa do not require invasive procedures to procure a sample. A broad range of sperm biomarkers and tests have been described as useful for the assessment of the sperm function. However, these approaches appear limited considering the current state of the art of molecular diagnostics that could be developed for this purpose. In this review, we outline the suite of sperm biomarkers that are currently in use to assess human male fertility status. Their use as indicators of genotoxic exposure will be discussed.

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Significance of sperm characteristics in the evaluation of male infertility

Cited by 245 publications

References 20 publications

Apoptotic sperm biomarkers and their correlation with conventional sperm parameters and male fertility potential

Apoptotic sperm biomarkers and their correlation with conventional sperm parameters and male fertility potential

Sperm DNA Fragmentation is Significantly Increased in Those Men with Morphologically Abnormal Spermatozoa

Spermatozoa as biomarkers for the assessment of human male infertility and genotoxicity

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