Significance of stroma in biology of oral squamous cell carcinoma

Boras, Vanja Vučičević; Fučić, Aleksandra; Virag, Mihajlo; Gabrić, Dragana; Blivajs, Igor; Tomasović-Lončarić, Čedna; Rakušić, Zoran; Bišof, Vesna; Novère, Nicolas Le; Vrdoljak, Danko Velimir

doi:10.5301/tj.5000673

Cited by 27 publications

(24 citation statements)

References 60 publications

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“…Fibroblasts in TME are activated by tumor cells to form cancer associated fibroblasts (CAFs), which play critical roles in processes associated with tumor progression [104]. CAFs interact with tumor cells and secrete cytokines, inflammatory cytokines, and extracellular vesicles to the microenvironment and directly supply metabolites to tumor cells to support their survival and proliferation [105]. Recently, tumor–fibroblast cell fusion has been considered to be a part of the tumor–stroma interaction.…”

Section: Tumor–stromal Cell Fusionmentioning

confidence: 99%

Tumor Microenvironment and Cell Fusion

Jiang

Yan

et al. 2019

BioMed Research International

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Cell fusion is a highly regulated biological process that occurs under both physiological and pathological conditions. The cellular and extracellular environment is critical for the induction of the cell–cell fusion. Aberrant cell fusion is initiated during tumor progression. Tumor microenvironment is a complex dynamic system formed by the interaction between tumor cells and their surrounding cells. Cell–cell fusion mediates direct interaction between tumor cells and their surrounding cells and is associated with tumor initiation and progression. Various microenvironmental factors affect cell fusion in tumor microenvironment and generate hybrids that acquire genomes of both parental cells and exhibit novel characteristics, such as tumor stem cell-like properties, radioresistance, drug resistance, immune evasion, and enhanced migration and invasion abilities, which are closely related to the initiation, invasion, and metastasis of tumor. The phenotypic characteristics of hybrids are based on the phenotypes of parental cells, and the fusion of tumor cells with diverse types of microenvironmental fusogenic cells is concomitant with phenotypic heterogeneity. This review highlights the types of fusogenic cells in tumor microenvironment that can fuse with tumor cells and their specific significance and summarizes the various microenvironmental factors affecting tumor cell fusion. This review may be used as a reference to develop strategies for future research on tumor cell fusion and the exploration of cell fusion-based antitumor therapies.

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Section: Tumor–stromal Cell Fusionmentioning

confidence: 99%

Tumor Microenvironment and Cell Fusion

Jiang

Yan

et al. 2019

BioMed Research International

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“…Oral squamous cell carcinoma (OSCC) is a common malignancy of the head and neck, with more than 354,900 newly diagnosed cases each year worldwide, arising from the mucosal epithelium of the oral cavity and oropharynx. 1,2 The development of OSCC is a complex multistep process, and the main potential risk factors including smoking, 3 drinking, 3,4 and human papillomavirus. [5][6][7] Cancer therapy has improved rapidly over the past decade, in particular, advanced radiotherapy with or without chemotherapy, enhanced surgical procedures, and immunotherapy.…”

Section: Introductionmentioning

confidence: 99%

<p>Fisetin Modulates Human Oral Squamous Cell Carcinoma Proliferation by Blocking PAK4 Signaling Pathways</p>

Li¹,

Jia²,

Dai³

2020

DDDT

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Objective: Human oral squamous cell carcinoma (OSCC) is a major cause of mortality and morbidity worldwide. There is an urgent need to identify bioactive molecules and potential target genes that could inhibit carcinogenesis for OSCC therapy. Fisetin (3,7,3′,4′-tetrahydroxyflavone), a naturally occurring flavonoid, has been previously shown to have anti-proliferative activities in OSCC; however, its molecular mechanism is unknown. Methods: Colony formation, cell viability, Boyden chamber, wound healing, and tumor xenograft assays were used to detect the impact of fisetin on OSCC cells in vitro and in vivo. Western blot analysis was used to examine the corresponding protein expression. Results: Fisetin treatment significantly inhibited proliferation and promoted apoptosis by repressing PAK4 expression. Moreover, fisetin treatment attenuated cell migration by blocking PAK4 signaling pathways. In addition, the tumor xenograft showed anti-tumor growth effects of fisetin exposure in vivo. Conclusion: Fisetin may represent a potential therapeutic strategy for human OSCC by targeting PAK4 signaling pathways.

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“…Oral squamous cell carcinoma (OSCC) is recognized as the most common phenotype of oral cancer, accounting for approximately 3% of the malignancies worldwide [1]. Annually, there are more than 300,000 patients diagnosed with OSCC worldwide, which is within the top 10 morbidity of all cancers and continues to increase [2][3][4]. Consumptions of tobacco and alcohol are responsible for almost 90% of the OSCC cases, while oral hygiene, human papillomavirus, and dental status are also considered as the risk factors [5].…”

Section: Introductionmentioning

confidence: 99%

KRT84 is a potential tumor suppressor and good prognosis signature of oral squamous cell carcinoma

Liu

Ren

2020

Bioscience Reports

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Aims: Oral squamous cell carcinoma (OSCC) is a common oral cancer; however, current therapeutic approaches still show limited efficacy. Our research aims to explore effective biomarkers related to OSCC. Main methods: Gene expression profiles of paired OSCC tumor and paracancerous samples from The Cancer Genome Atlas (TCGA) were analyzed. mRNA and protein levels of KRT84 in OSCC cell line HSC-3 were measured by real-time quantitative polymerase chain reaction (RT-qPCR) and Western blot. KRT84 protein levels in OSCC tumor samples of different stages were determined by immunohistochemistry. Overall survival (OS) of OSCC samples was evaluated and association of multiple factors with OS was assessed. Key findings: Compared with paracancerous samples, 4642 DEGs were identified in OSCC tumor samples. Among them, KRT84 expression level in OSCC tumor tissues was obviously decreased, which was validated in HSC-3 cells. KRT84 expression level showed decreasing tendency with the increase of tumor grade and stage. Patients with low KRT84 expression level had inferior OS independently of multiple factors. Besides, antigen processing and presentation pathway were significantly activated in OSCC samples with high KRT84 expression. Elevated KRT84 mRNA as well as protein levels were confirmed by RT-qPCR and Western blot in OSCC and normal cell lines, and immunohistochemistry in OSCC tumor and paracancerous tissues. Significance: Our study suggests KRT84 as a tumor suppressor and good prognostic indicator for OSCC, which might be significant for OSCC diagnosis and treatment.

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Significance of stroma in biology of oral squamous cell carcinoma

Cited by 27 publications

References 60 publications

Tumor Microenvironment and Cell Fusion

Tumor Microenvironment and Cell Fusion

<p>Fisetin Modulates Human Oral Squamous Cell Carcinoma Proliferation by Blocking PAK4 Signaling Pathways</p>

KRT84 is a potential tumor suppressor and good prognosis signature of oral squamous cell carcinoma

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