In this study, heat transfer flow of Casson hybrid nanofluid over vertical stretching sheet with magnetic field effect is studied. Copper oxide and graphite oxide in methanol are considered as the hybrid nanoparticles. This analysis of study points out several aspects of flow physically which is related to transportation of heat. The conservation of partial differential equations (PDEs) are taken place into non-linear coupled ordinary differential equations (ODEs) by using transformation of dimensionless variables, and solution of these ODEs is performed using Chebyshev differential quadrature method (CDQM). Effects of many involved parameters like M, , , a/c, denotes the magnetic parameter, Casson parameter, the nanoparticles volume fraction and ratio parameter are shown through tables for skin friction and Nusselt number. Moreover, it is presented as sketching on temperature and velocity profiles briefly. Results revealed that the Casson hybrid nanofluid has highest value when <1 for Nusselt number, skin friction, and temperature profile. Moreover, it is lowest value when >1 for velocity profile and Nusselt number. It also is observed that, when the magnetic field and Cason parameter increase, this leads to an increase in the temperature profile and a decrease in the Nusselt number and the velocity profile. A comparison study is also made which compares the present result with published data is executed and findings meet with them.