Significance of the disc damage likelihood scale objectively measured by a non-mydriatic fundus camera in preperimetric glaucoma

Pahlitzsch, Milena; Torun, Necip; Erb, Carl; Bruenner, Jeanette; Maier, Anna Karina B; Gonnermann, Johannes; Bertelmann, Eckart; Klamann, Matthias K. J.

doi:10.2147/opth.s93213

Cited by 5 publications

(3 citation statements)

References 36 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Another method to evaluate the ONH is the DDLS, which was formerly measured by using a slit-lamp and can now be objectively analyzed by the Kowa fundus camera. The DDLS is a useful parameter in the diagnosis of preperimetric and advanced glaucoma and it showed a close correlation with visual field, CDR, and OCT parameters (23-26). This study presents the first objectively measured DDLS in uveitic glaucoma.…”

Section: Discussionmentioning

confidence: 84%

Secondary glaucoma in uveitis: comparison of the optic nerve head morphology among a nonmydriatic fundus camera, HRT, and SD-OCT

Pahlitzsch

Klamann

Jacob

et al. 2017

European Journal of Ophthalmology

Self Cite

View full text Add to dashboard Cite

show abstract

Section: Discussionmentioning

confidence: 84%

Secondary glaucoma in uveitis: comparison of the optic nerve head morphology among a nonmydriatic fundus camera, HRT, and SD-OCT

Pahlitzsch

Klamann

Jacob

et al. 2017

European Journal of Ophthalmology

Self Cite

View full text Add to dashboard Cite

show abstract

“…A related study by Pahlitzsch et al . on patients with preperimetric primary open-angle glaucoma reinforced the predictive power of the DDLS, which makes it an important tool in diagnosing glaucoma 21 . Kara-José et al .…”

Section: Introductionmentioning

confidence: 80%

Rim-to-Disc Ratio Outperforms Cup-to-Disc Ratio for Glaucoma Prescreening

Kumar

Seelamantula

Kamath

et al. 2019

Sci Rep

View full text Add to dashboard Cite

We present a novel and fully automated fundus image processing technique for glaucoma prescreening based on the rim-to-disc ratio (RDR). The technique accurately segments the optic disc and optic cup and then computes the RDR based on which it is possible to differentiate a normal fundus from a glaucomatous one. The technique performs a further categorization into normal, moderate, or severely glaucomatous classes following the disc-damage-likelihood scale (DDLS). To the best of our knowledge, this is the first engineering attempt at using RDR and DDLS to perform glaucoma severity assessment. The segmentation of the optic disc and cup is based on the active disc , whose parameters are optimized to maximize the local contrast. The optimization is performed efficiently by means of a multiscale representation, accelerated gradient-descent, and Green’s theorem. Validations are performed on several publicly available databases as well as data provided by manufacturers of some commercially available fundus imaging devices. The segmentation and classification performance is assessed against expert clinician annotations in terms of sensitivity, specificity, accuracy, Jaccard, and Dice similarity indices. The results show that RDR based automated glaucoma assessment is about 8% to 10% more accurate than a cup-to-disc ratio (CDR) based system. An ablation study carried out considering the ground-truth expert outlines alone for classification showed that RDR is superior to CDR by 5.28% in a two-stage classification and about 3.21% in a three-stage severity grading.

show abstract

“…40 A significant correlation between DDLS and HRT-GPA has also been reported in pre-perimetric glaucoma, reinforcing its utility in the early stages of disease. 41 Kumar et al described a novel automated fundus image processing technique for glaucoma pre-screening comparing cup-to-disc and rim-to-disc ratio and reported greater sensitivity (0.97 vs 0.92), specificity (0.97 vs 0.91), and accuracy (0.97 vs 0.91) of rim-disc based assessment compared to cup-to-disc-based assessment. 42 Ichhpujani et al reported that a relative afferent pupillary defect (RAPD) was detected with a sensitivity of 84% when the difference in DDLS scores between the two eyes is greater than 2 using standard swinging flashlight test.…”

mentioning

confidence: 99%

Spotlight on the Disc-Damage Likelihood Scale (DDLS)

Cheng¹,

Tatham²

2021

OPTH

View full text Add to dashboard Cite

The disc damage likelihood scale (DDLS) is a tool for classifying glaucomatous structural changes to the optic disc based on the radial width of the neuroretinal rim at its thinnest location, or if no rim is present, the extent of absence of the rim. Unlike cup disc ratio (CDR), the DDLS also considers disc size. Twenty years after its first description, the aim of this review was to critically appraise evidence for the DDLS and evaluate its role in current practice. A literature search by two independent authors identified 33 relevant articles for inclusion. Five studies evaluated reproducibility, 5 diagnostic performance, and 2 studies examined ability to detect progression. Eleven studies evaluated correlation between DDLS and other markers of glaucoma. Despite the widespread availability of imaging devices such as optical coherence tomography (OCT), clinical examination of the optic disc remains an essential component of glaucoma diagnosis and monitoring. The DDLS provides a reliable method for semi-quantitative clinical grading of the optic disc in glaucoma, with higher reproducibility than methods such as CDR.

show abstract

Significance of the disc damage likelihood scale objectively measured by a non-mydriatic fundus camera in preperimetric glaucoma

Cited by 5 publications

References 36 publications

Secondary glaucoma in uveitis: comparison of the optic nerve head morphology among a nonmydriatic fundus camera, HRT, and SD-OCT

Secondary glaucoma in uveitis: comparison of the optic nerve head morphology among a nonmydriatic fundus camera, HRT, and SD-OCT

Rim-to-Disc Ratio Outperforms Cup-to-Disc Ratio for Glaucoma Prescreening

Spotlight on the Disc-Damage Likelihood Scale (DDLS)

Contact Info

Product

Resources

About