Significance of the evaluation of asymptomatic microscopic haematuria in young men

Sparwasser, C.; Cimniak, H. U.; Treiber, Uwe; Pust, R

doi:10.1111/j.1464-410x.1994.tb07114.x

Cited by 17 publications

(14 citation statements)

References 23 publications

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“…However, Shu et al highlighted the importance of performing a renal biopsy on IMH patients because minimal urinary abnormality with normal renal function at presentation does not necessarily imply a favorable outcome in certain patients; in addition, tubular atrophy and interstitial fibrosis, but not glomerular change, correlate with a worse prognosis [23]. Sparwasser et al [24] suggested that a kidney biopsy be considered optional, and that once a diagnosis is established, repeated and unnecessary examinations can be avoided in young patients with persistent hematuria. Shen et al [4] suggested that the urinary albumin/creatinine ratio, serum IgA level, and serum IgA/C3 ratio can serve as non-invasive markers to predict the necessity of a renal biopsy in adult patients with IMH.…”

Section: Discussionmentioning

confidence: 99%

Natural History and Renal Pathology in Patients with Isolated Microscopic Hematuria

Kim

Shin

et al. 2009

Korean J Intern Med

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Background/AimsNo definite conclusions have been reached about the natural history of patients with isolated microscopic hematuria (IMH). In this study, we observed the natural history of patients with IMH and examined factors related to a pathologic diagnosis and subsequent prognosis.MethodsWe retrospectively evaluated 156 subjects with IMH who had a renal biopsy performed. Of the 156 subjects, 33.3% were diagnosed with IgA nephropathy, 23.7% with mesangial proliferative glomerulonephritis, 15.4% with glomerular minor lesion, and 12.8% with thin basement membrane nephropathy; 6.4% had normal biopsies.ResultsWe followed up with 100 subjects for about 31 months. During this follow-up period, two subjects who had received a pathologic diagnosis of IgA nephropathy developed chronic kidney disease. During the course of the study, one of these subjects presented with proteinuria and hypertension and the other with proteinuria. The overall incidences of proteinuria and hypertension were 6% and 5% respectively.ConclusionsThe prognosis for patients with IMH was relatively favorable, but patients developing proteinuria and/or hypertension require careful observation and management during the follow-up period.

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Section: Discussionmentioning

confidence: 99%

Natural History and Renal Pathology in Patients with Isolated Microscopic Hematuria

Kim

Shin

et al. 2009

Korean J Intern Med

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“…In addition, tubular atrophy and interstitial fibrosis, but not glomerular change, correlated with a worse prognosis. Sparwasser et al [14] suggested that a kidney biopsy is considered optional; once a diagnosis was established, repeated and unnecessary examinations can be avoided in young patients with persistent hematuria. We aimed to demonstrate the importance of renal biopsy and essentiality of therapy to patients with IgAN and isolated hematuria by analyzing the pathological features of them.…”

Section: Discussionmentioning

confidence: 99%

Renal Biopsy Findings of Patients Presenting with Isolated Hematuria: Disease Associations

et al. 2012

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Background: Most nephrologists have believed that patients with isolated hematuria (IH) generally do not require treatment and have a good prognosis. The aim of this study was to analyze the pathological characteristics and emphasize the importance of renal biopsy for patients with IH. Methods: The pathological characteristics of 90 patients with IgA nephropathy confirmed by renal biopsy and presenting with IH were reviewed. We analyzed their pathological features according to the Oxford classification by using light and immunofluorescence. Results: Total samples included 68 females and 22 males. The age of onset with IH focuses on 20–30 years. At presentation, the focal and/or segmental glomerulosclerosis (FSGS) was the most frequent diagnosis (52.22%). The distribution of hematuria focused on 20–40 thousand. 46.67% of cases had global glomerulosclerosis which excluded the physical glomerular sclerosis, and the incidence of crescent formation was 24.44%. However, the proportion of glomerular sclerosis was mainly concentrated in less than 10%. Direct immunofluorescence showed simple IgA deposition was the most common (43.33%). 46.67% of patients had accompanying complement deposition, and 92.89% had complement 3 deposition. According to the Oxford classification, M₁S₀E₀T₀ accounted for 53.33%. The incidence of M, S, E, and T was 100, 30, 14.44, and 22.22% respectively. 46.67% of patients included two or more pathological lesions. Conclusions: FSGS played an important role in patients with IgA nephropathy who presented with IH. For those patients, renal biopsy was a valuable diagnostic tool and should be offered in clinical settings to provide them with maximal potential benefits.

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“…IgA nephropathy, a form of glomerulonephritis defined histologically by glomerular IgA deposits, accounted for the majority of cases with a glomerular source. 7 In a series of 165 patients, renal biopsies were performed after renal imaging and cystoscopy. No abnormalities were noted on renal biopsy in 87 patients.…”

Section: Clinical Relevancementioning

confidence: 99%

Microscopic Hematuria

2003

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Significance of the evaluation of asymptomatic microscopic haematuria in young men

Abstract: Even in young patients, microscopic haematuria should be investigated and followed thoroughly. Renal biopsy seems to be optional: once a diagnosis is established repeated and unnecessary examinations can be avoided.

Cited by 17 publications

References 23 publications

Natural History and Renal Pathology in Patients with Isolated Microscopic Hematuria

Natural History and Renal Pathology in Patients with Isolated Microscopic Hematuria

Renal Biopsy Findings of Patients Presenting with Isolated Hematuria: Disease Associations

Microscopic Hematuria

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