Significance of the Immunohistochemical Expression of Bone Morphogenetic Protein‐4 in Bone Maturation after Maxillary Sinus Grafting in Humans

Torrecillas-Martínez, Laura; Galindo‐Moreno, Pablo; Ávila‐Ortiz, Gustavo; Ortega-Oller, Inmaculada; Monje, Alberto; Hernández‐Cortés, Pedro; Aguilar, David; O’Valle, Francisco

doi:10.1111/cid.12354

Cited by 8 publications

(8 citation statements)

References 28 publications

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“…This result is in concordance with a previous in vivo study that investigated bone formation with BMP-2 in the rabbit maxillary sinus during the early healing period [1]. Furthermore, a recent clinical trial showed a significantly higher amount of mineralized bone formation in the higher expression of the BMP-4 group after maxillary sinus augmentation [8], which indicates that faster and greater bone formation would be induced by the BMPs.…”

Section: Discussionsupporting

confidence: 91%

Increased osteoinductivity and mineralization by minimal concentration of bone morphogenetic protein-2 loaded onto biphasic calcium phosphate in a rabbit sinus

Kim

Kook

Lee

et al. 2016

J Periodontal Implant Sci

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PurposeThe purpose of the present study was to evaluate the effectiveness of a minimal concentration of bone morphogenetic protein-2 (BMP-2) in terms of quantitative and qualitative analyses of newly formed bone in a rabbit maxillary sinus model.MethodsIn 7 rabbits, sinus windows were prepared bilaterally. Biphasic calcium phosphate (BCP) loaded with 0.05 mg/mL BMP-2 was grafted into one sinus (the BMP group) and saline-soaked BCP was placed into the other (the control group) in each animal. The animals were allowed an 8-week healing period before being sacrificed. Specimens including the augmented area and surrounding tissues were then removed and evaluated both radiographically and histologically.ResultsThere was a difference in the mineralization of new bone between the groups. In the BMP group, the greater part of the new bone consisted of mature lamellar bone with an evident trabecular pattern, whereas the control group showed mostly woven bone, consisting only partially of lamellar bone. Histometrically, the area of new bone was significantly greater (4.55±1.35 mm2 vs. 2.99±0.86 mm2) in the BMP group than in the control group (P<0.05); however, the total augmentation volumes were not significantly different between the groups.ConclusionsWithin the limitations of this study, it can be suggested that a minimal concentration of BMP-2 (0.05 mg/mL) had an osteoinductive effect with accelerated mineralization in a rabbit sinus model using a BCP carrier.

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Section: Discussionsupporting

confidence: 91%

Increased osteoinductivity and mineralization by minimal concentration of bone morphogenetic protein-2 loaded onto biphasic calcium phosphate in a rabbit sinus

Kim

Kook

Lee

et al. 2016

J Periodontal Implant Sci

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“…The aim of maxillary sinus augmentation is to restore the ideal bone height, enabling dental implant placement 1 . Some studies have proposed the use of bone substitutes to contribute to the maintenance of bone volume and new bone formation in the maxillary sinus [2][3][4][5][6][7] . The autogenous bone graft is still the most predictable and favourable for bone grafting because of its osteogenic, osteoinductive, and osteoconductive properties 8,9 .…”

mentioning

confidence: 99%

Comparative study of volumetric changes and trabecular microarchitecture in human maxillary sinus bone augmentation with bioactive glass and autogenous bone graft: a prospective and randomized assessment

Pereira

Menezes

Bonardi

et al. 2018

International Journal of Oral and Maxillofacial Surgery

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The aim of this study was to compare the volumetric changes and the new bone microarchitecture in human maxillary sinuses augmented with bioactive glass (Biogran) alone, bioactive glass combined with autogenous bone graft (1:1), or autogenous bone graft alone. Twelve maxillary sinuses were grafted with bioactive glass (group 1), nine with bioactive glass mixed with autogenous bone graft 1:1 (group 2), and 12 with autogenous bone graft (group 3). Patients underwent cone beam computed tomography 15days after the procedure to determine the initial volume of the graft (T1) and again 6 months later (T2). Biopsies were obtained at the time of dental implant placement and were subjected to micro-computed tomography. The volumetric change was 44.2% in group 1, 37.9% in group 2, and 45.7% in group 3 (P>0.05). The trabecular microarchitecture results showed that the materials used in groups 1 and 2 were good bone substitutes. However, the addition of 50% bioactive glass to autogenous bone graft improved the microarchitecture of the graft. Furthermore, the results for volumetric changes indicated that bioactive glass, its association with autogenous bone graft in a 1:1 ratio, and autogenous bone graft alone have similar resorption.

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“…54 Bone morphogenetic protein (BMP)-4 has been shown to induce osteogenic differentiation of osteoblasts from osteoprogenitor cells. 55 Interaction of BMP-2, BMP-4, and BMP-7 may contribute to osteoinduction. 51…”

Section: Discussionmentioning

confidence: 99%

“…53 The osteoclasts follow Haversian canals, resorbing allograft bone and releasing embedded bone morphogenetic protein and growth factors, and then change to osteoblasts and eventually to osteocytes. 35,55,59–65 The process of new bone formation and remodeling initiated by osteoclastic resorption has been called reverse creeping substitution. 57…”

Section: Discussionmentioning

confidence: 99%

Nasal Dorsal Augmentation with Freeze-Dried Allograft Bone: 10-Year Comprehensive Review

Clark

Pham²,

Ciminello

et al. 2019

Plastic &Amp; Reconstructive Surgery

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Significance of the Immunohistochemical Expression of Bone Morphogenetic Protein‐4 in Bone Maturation after Maxillary Sinus Grafting in Humans

Abstract: Our findings suggest that the native expression of BMP-4 appears to be associated with normal bone homeostasis and reparation in grafted and nongrafted maxillary sites.

Cited by 8 publications

References 28 publications

Increased osteoinductivity and mineralization by minimal concentration of bone morphogenetic protein-2 loaded onto biphasic calcium phosphate in a rabbit sinus

Increased osteoinductivity and mineralization by minimal concentration of bone morphogenetic protein-2 loaded onto biphasic calcium phosphate in a rabbit sinus

Comparative study of volumetric changes and trabecular microarchitecture in human maxillary sinus bone augmentation with bioactive glass and autogenous bone graft: a prospective and randomized assessment

Nasal Dorsal Augmentation with Freeze-Dried Allograft Bone: 10-Year Comprehensive Review

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