Significance of Urinary Tartaric Acid

Lord, Richard S.; Burdette, Cheryl; Bralley, J. Alexander

doi:10.1373/clinchem.2004.036368

Cited by 21 publications

(20 citation statements)

References 7 publications

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“…1). Tartarate, derived from food preparation43, also exhibited significant increases in the WG group in relation to the RG group (Table 1 and Supplementary Fig. 1).…”

Section: Resultsmentioning

confidence: 92%

Urinary Biomarkers of Whole Grain Wheat Intake Identified by Non-targeted and Targeted Metabolomics Approaches

Zhu

Wang

et al. 2016

Sci Rep

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Mounting evidence suggests that whole grain (WG) intake plays an important role in chronic disease prevention. However, numerous human studies have failed to produce clear-cut conclusions on this topic. Here, a combination of non-targeted and targeted metabolomics approaches, together with kinetic studies, was used to investigate biomarkers of WG wheat intake and further explore the diet-disease associations. Via these integrated approaches, forty-one compounds were identified as the most discriminating endogenous metabolites after WG versus refined grain (RG) wheat bread consumption. The corresponding biological assessment of these endogenous changes suggests that, in contrast to RG consumption, WG wheat consumption may facilitate antioxidant defense systems and moderate the risk factors of cancer, cardiovascular diseases, and other chronic diseases. A panel of urinary markers consisting of seven alkylresorcinol metabolites and five benzoxazinoid derivatives as specific biomarkers, as well as five phenolic acid derivatives, was also established to cover multiple time points and longer time periods for correctly and objectively monitoring WG wheat intake. Through these findings, we have established a comprehensive biomarker pool to better assess WG wheat consumption, and to monitor the endogenous changes that are linked to health effects of WG wheat consumption.

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“…1). Tartarate, derived from food preparation43, also exhibited significant increases in the WG group in relation to the RG group (Table 1 and Supplementary Fig. 1).…”

Section: Resultsmentioning

confidence: 92%

Urinary Biomarkers of Whole Grain Wheat Intake Identified by Non-targeted and Targeted Metabolomics Approaches

Zhu

Wang

et al. 2016

Sci Rep

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“…The increase in urinary tartarate in patients with CMA is particularly interesting, as tartarate is not produced in human metabolism (26) and could thus serve as a marker for intestinal permeability and microbial metabolism in the intestine. For the sources of tartarate, dietary intake apparently plays the most important part (27), although yeasts may also produce tartarate (26).…”

Section: Discussionmentioning

confidence: 99%

Cow’s milk allergy is associated with changes in urinary organic acid concentrations

Salmi

Kuitunen

Viljanen

et al. 2010

Pediatric Allergy Immunology

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Cow's milk allergy (CMA) is the most common form of food allergy affecting 2.5% of children, but the diagnosis is often difficult. Both intestinal microbiota and barrier function seem to be disturbed in patients with food allergies, and administration of probiotics has been shown to normalize intestinal microbiota and alleviate symptoms. We hypothesized that the differences in intestinal metabolic activity and permeability could lead to detectable changes in the end-products of metabolism in patients with CMA. This could offer new diagnostic possibilities. The urinary concentrations of 37 organic acids were studied by a mass spectrometry-based method in 35 infants aged under 1 yr with atopic eczema, 16 of them having CMA diagnosed with a double-blind placebo-controlled food challenge test. The control group consisted of the remaining 19 infants with only atopic eczema. In a second study, Lactobacillus rhamnosus GG (LGG) or placebo was administered to the infants with CMA for 4 wk and the urinary organic acids were analysed again. CMA patients and patients with only atopic eczema had statistically significant differences in urinary concentrations of hydroxybutyrate (p<0.001); adipate and isocitrate (p<0.01 for both); homovanillate, suberate, tartarate, 3-indoleacetate and 5-hydroxyindoleacetate (p<0.05 for all). These concentrations did not change significantly following LGG administration to the CMA patients, but a trend towards the control group was seen. Thus, CMA is associated with changes in some urinary organic acid levels. These differences between atopic infants with and without CMA could be investigated as a novel approach for CMA diagnosis.

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“…Ethanol and ethylglucuronide can also be used to assess consumption of alcoholic beverages in general to supplement using resveratrol alone. Despite the fact that many studies have focused on the identification of wine [40,41] or grape juice [42] biomarkers, we are not aware of any studies reporting (quantitative) biomarkers of grape intake to date. The present work applies a new analytical pipeline to assess tartaric acid as a quantitative biomarker of grape intake that could be used in clinical and epidemiological studies in order to assess accurate grape intake.…”

Section: Limitations In the Proposed Strategy For The Quantification mentioning

confidence: 99%

An Analytical Pipeline for Quantitative Characterization of Dietary Intake: Application To Assess Grape Intake

García-Pérez

Posma

Chambers

et al. 2016

J. Agric. Food Chem.

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Significance of Urinary Tartaric Acid

Cited by 21 publications

References 7 publications

Urinary Biomarkers of Whole Grain Wheat Intake Identified by Non-targeted and Targeted Metabolomics Approaches

Urinary Biomarkers of Whole Grain Wheat Intake Identified by Non-targeted and Targeted Metabolomics Approaches

Cow’s milk allergy is associated with changes in urinary organic acid concentrations

An Analytical Pipeline for Quantitative Characterization of Dietary Intake: Application To Assess Grape Intake

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