Significant association among residual SYNTAX score, non-culprit major adverse cardiac events, and greyscale and virtual histology intravascular ultrasound findings: a substudy from the PROSPECT study

Fujino, Akiko; Kadohira, Tadayuki; Redfors, Björn; Maehara, Akiko; Serruys, Patrick W.; Mintz, Gary S.; Stone, Gregg W.; Généreux, Philippe

doi:10.4244/eij-d-18-00681

Cited by 16 publications

(12 citation statements)

References 13 publications

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“…Baseline characteristics were compared between patients with complete and incomplete revascularization using the anatomic definition of incomplete revascularization adopted in other studies: rSS > 8. 5 , 17 Continuous data are presented as mean ± standard deviation or median (interquartile range [IQR]) and were compared between groups (complete vs incomplete revascularization) using the Student t test or Mann–Whitney test, as appropriate. Categorical variables were compared between groups using the chi-square test.…”

Section: Methodsmentioning

confidence: 99%

Residual SYNTAX Score and One-Year Outcome in Elderly Patients With Acute Coronary Syndrome

et al. 2020

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Background: The residual burden of coronary artery disease after percutaneous coronary intervention (PCI) has been associated with worse ischemic outcome. However, data are conflicting in elderly patients. The aim of our study was to verify the incremental value of the residual Synergy Between Percutaneous Coronary Intervention With Taxus and Cardiac Surgery (SYNTAX) score (rSS) over clinical variables and baseline SYNTAX score (bSS) in predicting 1-year mortality or cardiovascular events. Methods: A post hoc analysis of data collected in the Elderly-ACS 2 multicenter randomized trial was performed. We included 630 patients aged > 75 years with multivessel coronary disease undergoing CJC Open 2 (2020) 236e243

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Section: Methodsmentioning

confidence: 99%

Residual SYNTAX Score and One-Year Outcome in Elderly Patients With Acute Coronary Syndrome

et al. 2020

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“…The CULPRIT-SHOCK trial [18], which enrolled 587 patients, reported a strong signi cant correlation between rSS and 30-day and 1-year mortality in a large group of patients with cardiac stroke. A previous study showed that plaque morphology was signi cantly correlated with rSS and that rSS and plaque burden ≥ 70% independently predicted MACEs based on intravascular ultrasound [19]. OCT for the identi cation of neointimal microstructures such as TCFA, macrophage accumulation, calci ed deposits, microvessels, and cholesterol crystals may be more useful than intravascular ultrasound in determining the optimal treatment strategy [20,21].…”

Section: Association Of High Rss With Macesmentioning

confidence: 99%

Prognostic Value of Characteristics of Plaque Combined With Residual Syntax Score Among Patients With STEMI Undergoing Primary PCI: an Intravascular Optical Coherence Tomography Study

Zhao

Wang

Chen

et al. 2021

Preprint

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AimThe present study aimed to explore these characteristics, particularly thin-cap fibroatheroma (TCFA), in relation to residual syntax score (rSS) in patients who presented with acute MI.Methods and outcomesA total of 434 consecutive patients with MI aged ≥18 years who had STEMI underwent primary PCI. Notably, compared with other subgroups, the presence of TCFA in culprit lesions and a higher level of rSS, were significantly associated with MACE. When rSS was divided into three groups, high rSS levels were associated with a higher incidence of MACE, in the subgroups of without TCFA (P= 0.005), plaque erosion (P= 0.045), macrophage infiltration (P= 0.026), and calcification (P= 0.002). AUC of ROC curve was 0.794 and 0.816, whereas the AUC of the survival ROC was 0.798 and 0.846.ConclusionThe results of this study could be used in clinical practice to support risk stratification.Trial registrationThis study was registered at ClinicalTrials.gov as NCT03593928.

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“…However, the absolute benefit: risk profile for cangrelor was greatest during PCI in complex coronary anatomy. In a substudy of the PROSPECT trial, (37) virtual histology and grey scale intravascular ultrasound (IVUS) was a predictor of a suboptimal final angiographic result reflected as a high residual Syntax Score after intervention. A detailed Expert consensus review has provided detail on characterisation of acute coronary lesions using IVUS or OCT and suggested a triaged therapeutic approach.…”

Section: Timing Of Treatmentmentioning

confidence: 99%

The year in cardiology: acute coronary syndromes

Banning¹,

Crea

Lüscher

2020

SAHJ

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Significant association among residual SYNTAX score, non-culprit major adverse cardiac events, and greyscale and virtual histology intravascular ultrasound findings: a substudy from the PROSPECT study

Cited by 16 publications

References 13 publications

Residual SYNTAX Score and One-Year Outcome in Elderly Patients With Acute Coronary Syndrome

Residual SYNTAX Score and One-Year Outcome in Elderly Patients With Acute Coronary Syndrome

Prognostic Value of Characteristics of Plaque Combined With Residual Syntax Score Among Patients With STEMI Undergoing Primary PCI: an Intravascular Optical Coherence Tomography Study

The year in cardiology: acute coronary syndromes

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