Significant association between rs28362491 polymorphism in NF-κB1 gene and coronary artery disease: a meta-analysis

Wang, Yanwei; Wu, Bianwen; Miao, Huawei

doi:10.1186/s12872-020-01568-0

Cited by 11 publications

(10 citation statements)

References 42 publications

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“…SNP rs28362491 in the ubiquitous transcription factor NF- κΒ was reported to be involved in the expression of immune-modulating genes due to its impact on NF- κΒ gene transcription [ 41 ]. Therefore, this SNP has been implicated in inflammatory diseases including cardiovascular diseases [ 14 ]. In the meta-analysis by Wang et al, the deletion allele was shown to be associated with CV diseases even after stratification by ethnicity and gender [ 14 ].…”

Section: Discussionmentioning

confidence: 99%

“…Therefore, this SNP has been implicated in inflammatory diseases including cardiovascular diseases [ 14 ]. In the meta-analysis by Wang et al, the deletion allele was shown to be associated with CV diseases even after stratification by ethnicity and gender [ 14 ]. However, a corresponding association could not be confirmed in the present study in the cohort of CV patients.…”

Section: Discussionmentioning

confidence: 99%

“…Due to their functional consequences, all described SNPs are highly involved in the immune response and could thus represent a possible link between periodontal and cardiovascular diseases. And indeed, in a variety of case-control studies as well as in meta-analyses, their impact on periodontitis as well as CV diseases was assessed (CD14 [15][16][17], NF-κΒ [14,18,19], TLR2 [20,21], and TLR4 [4,22,23]).…”

Section: Introductionmentioning

confidence: 99%

“…In the NK- κΒ gene, the rs28362491 SNP represents a 4 bp ATTG insertion/deletion variation at position −94 bp of the promoter. This polymorphic site has been reported to have a major impact on gene expression, with deletion of ATTG resulting in reduced promoter activity [ 14 ]. Due to their functional consequences, all described SNPs are highly involved in the immune response and could thus represent a possible link between periodontal and cardiovascular diseases.…”

Section: Introductionmentioning

confidence: 99%

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Polymorphism of CD14 Gene Is Associated with Adverse Outcome among Patients Suffering from Cardiovascular Disease

Schulz

Zielske

Schneider

et al. 2021

Mediators of Inflammation

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Background. The biological link between severe periodontitis and cardiovascular disease is well established. Both complex inflammatory diseases are influenced by genetic background. Therefore, the impact of genetic variations of receptors of the innate immune system—(Toll-like receptors (TLRs)) TLR2, TLR4, cluster of differentiation 14 (CD14), and the transcription factor nuclear factor-κΒ (NF-κB)—was investigated. Materials and Methods. In this study (ClinicalTrials.gov identifier: NCT01045070), 1002 cardiovascular (CV) patients were included. In a 3-year follow-up period, new vascular events were assessed. SNPs in CD14 (rs2569190), NF-κΒ (rs28362491), TLR2 (rs5743708), and TLR4 (rs4986790) were genotyped. The impact of these genetic variants on severe periodontitis as well as on CV outcome was assessed. Results. All investigated genetic variants were not associated with preexisting CV events or severe periodontitis in CV patients. In Kaplan-Meier survival analyses, the CT genotype of CD14 single-nucleotide polymorphism (SNP) rs2569190 was shown to be an independent predictor for combined CV endpoint (log rank: p = 0.035 ; cox regression; hazard ratio: 1.572; p = 0.044 ) as well as cardiovascular death (log rank: p = 0.019 ; cox regression; hazard ratio: 1.585; p = 0.040 ) after three years of follow-up. Conclusions. SNPs in CD14, NF-κΒ, TLR2, and TLR4 are no risk modulators for preexisting CV events or severe periodontitis in CV patients. The CT genotype of CD14 SNP rs2569190 provides prognostic value for further CV events within 3 years of follow-up.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Polymorphism of CD14 Gene Is Associated with Adverse Outcome among Patients Suffering from Cardiovascular Disease

Schulz

Zielske

Schneider

et al. 2021

Mediators of Inflammation

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“…Therefore, NFKBIZ variant was an independent risk factor for developing early-onset CAD [ 50 ]. However, in a recent meta-analysis of 13 case-control studies with 17 individual cohorts containing 9378 cases and 10,738 controls, the mutant D allele in NFKB1 rs28362491 locus increased the risk of CAD [ 51 ].…”

Section: Nf-κb Genetic Variants and Cardiometabolic Comorbiditymentioning

confidence: 99%

Genetic Variants of the NF-κB Pathway: Unraveling the Genetic Architecture of Psoriatic Disease

Queiró

Coto-Segura

González-Lara

et al. 2021

IJMS

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Psoriasis is a multifactorial genetic disease for which the genetic factors explain about 70% of disease susceptibility. Up to 30–40% of psoriasis patients develop psoriatic arthritis (PsA). However, PsA can be considered as a “disease within a disease”, since in most cases psoriasis is already present when joint complaints begin. This has made studies that attempt to unravel the genetic basis for both components of psoriatic disease enormously difficult. Psoriatic disease is also accompanied by a high burden of comorbid conditions, mainly of the cardiometabolic type. It is currently unclear whether these comorbidities and psoriatic disease have a shared genetic basis or not. The nuclear factor of kappa light chain enhancer of activated B cells (NF-κB) is a transcription factor that regulates a plethora of genes in response to infection, inflammation, and a wide variety of stimuli on several cell types. This mini-review is focused on recent findings that highlight the importance of this pathway both in the susceptibility and in the determinism of some features of psoriatic disease. We also briefly review the importance of genetic variants of this pathway as biomarkers of pharmacological response. All the above may help to better understand the etiopathogenesis of this complex entity.

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Interaction of dietary patterns with rs28362491 on severity of coronary artery stenosis in patients undergoing coronary angiography

Darabi,

Seyed Hosseini,

Sarebanhassanabadi

et al. 2023

Sci Rep

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Coronary artery disease (CAD) is one of the most important cardiovascular diseases. Lifestyle and genetic factors play important roles in the development of CAD. The aim of the study is to examine the interaction of dietary patterns and genes on the likelihood of abnormal lipid profile and coronary artery stenosis in Iranians undergoing coronary angiography. This cross-sectional study was performed on 440 patients who underwent coronary angiography. The factor analysis method was used to extract dietary patterns. Commercial kits have been used to assess biochemical parameters. The detection of the rs28362491 genotype was carried out by the method of restriction fragment length polymorphism. Traditional (TDP) and western dietary pattern (WDP) were extracted. We observed an interaction of adherence to TDP and rs28362491 on the odds of having a high Gensini score. These interactions indicated that higher adherence to TDP was associated with higher odds of having a high Gensini score for patients with DD genotype than for those with II genotype. (OR 2.33, 95%CI 1.00–5.44; P = 0.05). These interactions remained statistically significant even after confounder variables. We observed an interaction between higher adherence to TDP and rs28362491 variants on the odds of high low-density lipoprotein cholesterol levels (P = 0.04) in the unadjusted model. We found a significant interaction of this polymorphism and higher adherence to WDP on the odds of having a high Gensini score in the unadjusted model (P = 0.04). This study provides a basis for future research on NF-KB1 gene and diet interaction. More large-scale longitudinal studies are needed to validate these findings.

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Significant association between rs28362491 polymorphism in NF-κB1 gene and coronary artery disease: a meta-analysis

Cited by 11 publications

References 42 publications

Polymorphism of CD14 Gene Is Associated with Adverse Outcome among Patients Suffering from Cardiovascular Disease

Polymorphism of CD14 Gene Is Associated with Adverse Outcome among Patients Suffering from Cardiovascular Disease

Genetic Variants of the NF-κB Pathway: Unraveling the Genetic Architecture of Psoriatic Disease

Interaction of dietary patterns with rs28362491 on severity of coronary artery stenosis in patients undergoing coronary angiography

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