Significant association factors of bone mineral density in Taiwan adults

Abstract

Objective: To examine the biofactors associated with bone mineral density (BMD) in southern Taiwanese adults. Materials and Methods: The medical records of 3242 adults who underwent health examinations between June 2014 and February 2018 at a regional hospital in southern Taiwan were reviewed. The data collected included health history, anthropomorphic characteristics, clinical laboratory results, biochemical parameters, and BMD. The data were used to identify the biofactors associated with BMD/T-scores at the lumbar spine and femoral neck by multivariate linear regression analysis with the stepwise method. Results: The mean age of the patients was 58.1 years, and 71.4% were male. Factors positively correlated with BMD and the T-score included body mass index (BMI), male gender, calcium, and creatinine. Age, alkaline phosphatase (ALP), triiodothyronine, serum thyroxine, low-density lipoprotein cholesterol, and a history of hyperlipidemia were negatively correlated with BMD and the T-score. Conclusion: The associated biofactors reported here were similar to and had similar relationships as the biofactors identified in previous literature reports. Not all of the sites examined for BMD were influenced by the same association factors, except for BMI, male gender, age, and ALP, implying that the bone remodeling processes that shape BMD involve a complex regulatory network and demonstrating that our extracted factors are the most useful for clinical practice.

The correlation between serum levels of alkaline phosphatase and bone mineral density in adults aged 20 to 59 years

“…[11,12] Recently, its serum levels were correlated with bone metabolism and BMD. [13][14][15][16][17] Our study investigated this correlation in adults aged 20 to 59 years and found a negative correlation between serum ALP levels and pelvic BMD, which persisted after adjusting for confounders (Table 2). Females exhibited a more significant negative correlation between serum ALP levels and pelvic BMD than that exhibited by males.…”

“…[11,12] Recently, its serum levels were correlated with bone metabolism and BMD. [13–17] Our study investigated this correlation in adults aged 20 to 59 years and found a negative correlation between serum ALP levels and pelvic BMD, which persisted after adjusting for confounders (Table 2).…”