Significant association of antiphospholipid antibodies and TNF-alpha: Marker of severe atherogenic profile of patients with type II diabetes mellitus without micro and/or macrovascular complications

Bećarevic, Mirjana; Seferović, Jelena P.; Ignjatović, Svetlana; Singh, Sandra; Majkić-Singh, Nada

doi:10.1016/j.cyto.2011.05.001

Cited by 6 publications

(3 citation statements)

References 23 publications

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“…However, whether it exists in the corpus cavernosum tissue under physiological conditions has not been reported. APOH protein, also called β2 glycoprotein 1, plays an important role in diabetes, atherosclerosis and angiogenesis (Becarevic et al, 2011; Sakai et al, 2007). The relationship between APOH and platelets has been mostly studied and reported.…”

Section: Discussionmentioning

confidence: 99%

iTRAQ‐based identification of differentially expressed proteins in ED rat model induced by cold stress combined with environmental oestrogen

Zhang

Yiming

et al. 2022

Andrologia

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Section: Discussionmentioning

confidence: 99%

iTRAQ‐based identification of differentially expressed proteins in ED rat model induced by cold stress combined with environmental oestrogen

Zhang

Yiming

et al. 2022

Andrologia

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“…It is an autoimmune disease that is clinically characterized by the presence of thromboses (arterial and/or venous) and/or recurrent miscarriages. 1 –3 Thrombotic manifestations of the APS can occur in almost every organ of the human body. Kidney represents a major target organ for the aPL Abs in patients with APS, and it was reported that aPL Abs represented an independent factor that was associated with the occurrence and/or progression of nephropathy in patients with APS.…”

Section: Introductionmentioning

confidence: 99%

Antiphospholipid Antibodies and Renal Impairment Parameters in Diabetic Nephropathy: Preliminary Data

Bećarevic

Čabarkapa

Đerić

et al. 2016

Clin Appl Thromb Hemost

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“…Recently it has been suggested that an association between aPL Abs and TNF-alpha might be a predictor of a severe atherogenic profile in type II diabetes mellitus patients without vascular complications (12). In the present study we investigated the association of aPL Abs with adiponectin and NEFA in a wellformed group of type II diabetes mellitus patients without micro and/or macrovascular complications.…”

Section: Introductionmentioning

confidence: 99%

Adiponectin, Non-Esterified Fatty Acids and Antiphospholipid Antibodies in Type II Diabetes Mellitus

Bećarevic¹,

Seferović²,

Ignjatović³

et al. 2012

Journal of Medical Biochemistry

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Summary:The importance of the association of antiphospholipid antibodies (aPL Abs) with the features of type II diabetes mellitus has not yet been elucidated. The aim of this work was to investigate the association of aPL Abs with adiponectin and non-esterified fatty acids (NEFA) in type II diabetes mellitus patients without micro and/or macrovascular complications, and to analyze the differences between the male and female patients with regard to the abovementioned parameters. Male patients with type II diabetes mellitus showed a positive correlation between NEFA concentrations and anti-oxLDL antibodies (r=0.334, p=0.019). A weak, but statistically significant correlation between adiponectin concentrations and the IgM isotype of anti-annexin A5 antibodies was found in type II diabetes mellitus patients (r=0.285, p=0.011). The presence of a positive correlation between NEFA and anti-oxLDL antibodies might be useful in the detection of patients with premature atherosclerosis in type II diabetes mellitus patients without any micro and/or macrovascular complications among type II diabetes mellitus patients. Keywords: antiphospholipid antibodies, adipo nectin, diabetes mellitus type IIKratak sadr`aj: Zna~aj povezanosti antifosfolipidnih antite la (aPL Abs) sa odlikama dijabetesa tip II jo{ nije razja{ njen. Cilj rada bilo je ispitivanje povezanosti aPL Abs sa adiponektinom i neesterifikovanim masnim kiselinama (NEFA) kod pacijenata sa dijabetesom tip II bez mikro i/ili makrovaskularnih komplikacija i analiziranje razlika u navedenim parametrima izme|u mu{karaca i `ena sa dijabetesom. Kod mu{karaca sa dijabetesom tip II pokazana je po zitivna korelacija izme|u koncentracija NEFA i anti-oxLDL antitela (r=0,334, p=0,019). Slaba ali statisti~ki zna~ajna korelacija izme|u koncentracija adiponektina i IgM izotipa anti-aneksin A5 antitela prona|ena je kod pacijenata sa dijabetesom tip II (r=0,285, p=0,011). Pozitivna korelacija izme|u NEFA i anti-oxLDL antitela mogla bi da bude korisna u detekciji pacijenata sa prevremenom aterosklerozom u dijabetesu tip II bez mikro i/ili makrovaskularnih komplikacija.Klju~ne re~i: antifosfolipidna anti te la, adi po nektin, diabetes mellitus tip II

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Significant association of antiphospholipid antibodies and TNF-alpha: Marker of severe atherogenic profile of patients with type II diabetes mellitus without micro and/or macrovascular complications

Cited by 6 publications

References 23 publications

iTRAQ‐based identification of differentially expressed proteins in ED rat model induced by cold stress combined with environmental oestrogen

iTRAQ‐based identification of differentially expressed proteins in ED rat model induced by cold stress combined with environmental oestrogen

Antiphospholipid Antibodies and Renal Impairment Parameters in Diabetic Nephropathy: Preliminary Data

Adiponectin, Non-Esterified Fatty Acids and Antiphospholipid Antibodies in Type II Diabetes Mellitus

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