Significant contribution of autophagy in mitigating cytotoxicity of gadolinium ions

Takanezawa, Yasukazu; Nakamura, Ryosuke; Kusaka, Tomoya; Ohshiro, Yuka; Uraguchi, Shimpei; Kiyono, Masako

doi:10.1016/j.bbrc.2020.03.080

Cited by 10 publications

(3 citation statements)

References 36 publications

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“…From the perspective of studying the characteristics of autophagy and MeHg toxicity, we have revealed compounds that inhibit autophagy. 13,14) Furthermore, we demonstrated the adverse effects of gadolinium toxicity, 15,16) and the correlation between allergies and MeHg. 17) Additionally, we investigated the influence of highly unsaturated fatty acids on the tox-icity of MeHg, 18) as well as the impact of MeHg on adipocyte differentiation 19) and the toxicity resulting from trace inorganic Hg converted from MeHg, 20) in order to unravel the nature of MeHg toxicity and the cellular protective response against MeHg toxicity.…”

Section: Analysis Of Biological Defense Mechanisms Against Mehg Exposurementioning

confidence: 64%

Molecular Toxicology of Methylmercury and Phytoremediation of Toxic Metals for Human Health

et al. 2023

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The history of methylmercury (MeHg) toxicity research goes back to Minamata disease. In Japan, histopathological examination of patients afflicted with Minamata disease, alongside meticulous investigations at both in vitro and in vivo, were robustly undertaken to elucidate the deleterious effects of MeHg. It is not an overstatement to assert that Japanese investigations on MeHg toxicity have spearheaded global advancements in this field. Nevertheless, more than half a century has passed since the onset of Minamata disease, yet the intricacies of MeHg toxicity remains enigmatic. Moreover, environmental pollution of mercury and toxic metals is a global problem that needs to be solved. Therefore, our research has focused on, "toxicology of MeHg" and "remediation of mercury and other toxic metals". This review discusses the molecular mechanisms underlying roles of autophagy in MeHg responses of mammalian cells, identification of an anti-MeHg natural product, analysis of bacterial mercury-resistant gene, and plant biotechnology using bacterial transporters for phytoremediation.

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Section: Analysis Of Biological Defense Mechanisms Against Mehg Exposurementioning

confidence: 64%

Molecular Toxicology of Methylmercury and Phytoremediation of Toxic Metals for Human Health

et al. 2023

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“…Autophagy induction has been documented previously in cases of poisoning by heavy metals like cadmium and arsenic compounds [123]; ingestion of small doses of these compounds (in relation to ecological problems) was also found to be dangerous. Induction of autophagy has likewise been documented in experiments with gadolinium-based contrast agents [124]. Additionally, it should be noted that exercise (increased physical activity) can regulate LD dynamics in the normal and fatty liver by improving lipid metabolism [125].…”

Section: Autophagy Inductionmentioning

confidence: 91%

Lysosomotropic Features and Autophagy Modulators among Medical Drugs: Evaluation of Their Role in Pathologies

2020

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The concept of lysosomotropic agents significantly changed numerous aspects of cellular biochemistry, biochemical pharmacology, and clinical medicine. In the present review, we focused on numerous low-molecular and high-molecular lipophilic basic compounds and on the role of lipophagy and autophagy in experimental and clinical medicine. Attention was primarily focused on the most promising agents acting as autophagy inducers, which offer a new window for treatment and/or prophylaxis of various diseases, including type 2 diabetes mellitus, Parkinson’s disease, and atherosclerosis. The present review summarizes current knowledge on the lysosomotropic features of medical drugs, as well as autophagy inducers, and their role in pathological processes.

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“…Besides lipid peroxidation and ROS production, Gd (III) prompted the formation of autophagic vesicles, also revealing apoptotic and necrotic potential [42,110], pointing towards a multitude of cell death pathways being activated. Indeed, a decrease in cell viability, an increase in cell death through apoptosis, and autophagic activation have been associated with Gd (III) toxicity [10,30,34,40,[46][47][48]51,58,60,64,70,99,113]. Mitochondrial dysfunction [38,42,51,91,108,109] and suppressing mitochondria membrane potential [62,101] were also described.…”

Section: Reference Study Design Main Findingsmentioning

confidence: 99%

Toxicity Mechanisms of Gadolinium and Gadolinium-Based Contrast Agents—A Review

Coimbra,

Rocha,

Sousa

et al. 2024

IJMS

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Gadolinium-based contrast agents (GBCAs) have been used for more than 30 years to improve magnetic resonance imaging, a crucial tool for medical diagnosis and treatment monitoring across multiple clinical settings. Studies have shown that exposure to GBCAs is associated with gadolinium release and tissue deposition that may cause short- and long-term toxicity in several organs, including the kidney, the main excretion organ of most GBCAs. Considering the increasing prevalence of chronic kidney disease worldwide and that most of the complications following GBCA exposure are associated with renal dysfunction, the mechanisms underlying GBCA toxicity, especially renal toxicity, are particularly important. A better understanding of the gadolinium mechanisms of toxicity may contribute to clarify the safety and/or potential risks associated with the use of GBCAs. In this work, a review of the recent literature concerning gadolinium and GBCA mechanisms of toxicity was performed.

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Significant contribution of autophagy in mitigating cytotoxicity of gadolinium ions

Cited by 10 publications

References 36 publications

Molecular Toxicology of Methylmercury and Phytoremediation of Toxic Metals for Human Health

Molecular Toxicology of Methylmercury and Phytoremediation of Toxic Metals for Human Health

Lysosomotropic Features and Autophagy Modulators among Medical Drugs: Evaluation of Their Role in Pathologies

Toxicity Mechanisms of Gadolinium and Gadolinium-Based Contrast Agents—A Review

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